Cargando…
Protective Effect of Vaccine Doses and Antibody Titers Against SARS-CoV-2 Infection in Kidney Transplant Recipients
Patients undergoing kidney transplantation have a poor response to vaccination and a higher risk of disease progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effectiveness of vaccine doses and antibody titer tests against the mutant variant in these patients remains un...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294008/ https://www.ncbi.nlm.nih.gov/pubmed/37383842 http://dx.doi.org/10.3389/ti.2023.11196 |
_version_ | 1785063107392962560 |
---|---|
author | Chen, Chien-Chia Hsu, Meng-Kai Huang, Yi-Jen Lai, Mei-Jun Wu, Shu-Wei Lin, Min-Huey Hung, Hsu-Shan Lin, Yu-Chun Huang, Yu-Tsung Lee, Ya-Fen Tsai, Meng-Kun Lee, Chih-Yuan |
author_facet | Chen, Chien-Chia Hsu, Meng-Kai Huang, Yi-Jen Lai, Mei-Jun Wu, Shu-Wei Lin, Min-Huey Hung, Hsu-Shan Lin, Yu-Chun Huang, Yu-Tsung Lee, Ya-Fen Tsai, Meng-Kun Lee, Chih-Yuan |
author_sort | Chen, Chien-Chia |
collection | PubMed |
description | Patients undergoing kidney transplantation have a poor response to vaccination and a higher risk of disease progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effectiveness of vaccine doses and antibody titer tests against the mutant variant in these patients remains unclear. We retrospectively analyzed the risk of SARS-CoV-2 infection in a single medical center according to vaccine doses and immune responses before the outbreak. Among 622 kidney transplant patients, there were 77 patients without vaccination, 26 with one dose, 74 with two doses, 357 with three, and 88 with four doses. The vaccination status and infection rate proportion were similar to the general population. Patients undergoing more than three vaccinations had a lower risk of infection (odds ratio = 0.6527, 95% CI = 0.4324–0.9937) and hospitalization (odds ratio = 0.3161, 95% CI = 0.1311–0.7464). Antibody and cellular responses were measured in 181 patients after vaccination. Anti-spike protein antibody titer of more than 1,689.3 BAU/mL is protective against SARS-CoV-2 infection (odds ratio = 0.4136, 95% CI = 0.1800–0.9043). A cellular response by interferon-γ release assay was not correlated with the disease (odds ratio = 1.001, 95% CI = 0.9995–1.002). In conclusion, despite mutant strain, more than three doses of the first-generation vaccine and high antibody titers provided better protection against the omicron variant for a kidney transplant recipient. |
format | Online Article Text |
id | pubmed-10294008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102940082023-06-28 Protective Effect of Vaccine Doses and Antibody Titers Against SARS-CoV-2 Infection in Kidney Transplant Recipients Chen, Chien-Chia Hsu, Meng-Kai Huang, Yi-Jen Lai, Mei-Jun Wu, Shu-Wei Lin, Min-Huey Hung, Hsu-Shan Lin, Yu-Chun Huang, Yu-Tsung Lee, Ya-Fen Tsai, Meng-Kun Lee, Chih-Yuan Transpl Int Health Archive Patients undergoing kidney transplantation have a poor response to vaccination and a higher risk of disease progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effectiveness of vaccine doses and antibody titer tests against the mutant variant in these patients remains unclear. We retrospectively analyzed the risk of SARS-CoV-2 infection in a single medical center according to vaccine doses and immune responses before the outbreak. Among 622 kidney transplant patients, there were 77 patients without vaccination, 26 with one dose, 74 with two doses, 357 with three, and 88 with four doses. The vaccination status and infection rate proportion were similar to the general population. Patients undergoing more than three vaccinations had a lower risk of infection (odds ratio = 0.6527, 95% CI = 0.4324–0.9937) and hospitalization (odds ratio = 0.3161, 95% CI = 0.1311–0.7464). Antibody and cellular responses were measured in 181 patients after vaccination. Anti-spike protein antibody titer of more than 1,689.3 BAU/mL is protective against SARS-CoV-2 infection (odds ratio = 0.4136, 95% CI = 0.1800–0.9043). A cellular response by interferon-γ release assay was not correlated with the disease (odds ratio = 1.001, 95% CI = 0.9995–1.002). In conclusion, despite mutant strain, more than three doses of the first-generation vaccine and high antibody titers provided better protection against the omicron variant for a kidney transplant recipient. Frontiers Media S.A. 2023-06-13 /pmc/articles/PMC10294008/ /pubmed/37383842 http://dx.doi.org/10.3389/ti.2023.11196 Text en Copyright © 2023 Chen, Hsu, Huang, Lai, Wu, Lin, Hung, Lin, Huang, Lee, Tsai and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Health Archive Chen, Chien-Chia Hsu, Meng-Kai Huang, Yi-Jen Lai, Mei-Jun Wu, Shu-Wei Lin, Min-Huey Hung, Hsu-Shan Lin, Yu-Chun Huang, Yu-Tsung Lee, Ya-Fen Tsai, Meng-Kun Lee, Chih-Yuan Protective Effect of Vaccine Doses and Antibody Titers Against SARS-CoV-2 Infection in Kidney Transplant Recipients |
title | Protective Effect of Vaccine Doses and Antibody Titers Against SARS-CoV-2 Infection in Kidney Transplant Recipients |
title_full | Protective Effect of Vaccine Doses and Antibody Titers Against SARS-CoV-2 Infection in Kidney Transplant Recipients |
title_fullStr | Protective Effect of Vaccine Doses and Antibody Titers Against SARS-CoV-2 Infection in Kidney Transplant Recipients |
title_full_unstemmed | Protective Effect of Vaccine Doses and Antibody Titers Against SARS-CoV-2 Infection in Kidney Transplant Recipients |
title_short | Protective Effect of Vaccine Doses and Antibody Titers Against SARS-CoV-2 Infection in Kidney Transplant Recipients |
title_sort | protective effect of vaccine doses and antibody titers against sars-cov-2 infection in kidney transplant recipients |
topic | Health Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294008/ https://www.ncbi.nlm.nih.gov/pubmed/37383842 http://dx.doi.org/10.3389/ti.2023.11196 |
work_keys_str_mv | AT chenchienchia protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT hsumengkai protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT huangyijen protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT laimeijun protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT wushuwei protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT linminhuey protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT hunghsushan protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT linyuchun protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT huangyutsung protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT leeyafen protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT tsaimengkun protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients AT leechihyuan protectiveeffectofvaccinedosesandantibodytitersagainstsarscov2infectioninkidneytransplantrecipients |