Diabetes and cognitive decline: Challenges and future direction

There is growing evidence that diabetes can induce cognitive decline and dementia. It is a slow, progressive cognitive decline that can occur in any age group, but is seen more frequently in older individuals. Symptoms related to cognitive decline are worsened by chronic metabolic syndrome. Animal m...

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Autores principales: Ab-Hamid, Norhamidar, Omar, Norsuhana, Ismail, Che Aishah Nazariah, Long, Idris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294066/
https://www.ncbi.nlm.nih.gov/pubmed/37383592
http://dx.doi.org/10.4239/wjd.v14.i6.795
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author Ab-Hamid, Norhamidar
Omar, Norsuhana
Ismail, Che Aishah Nazariah
Long, Idris
author_facet Ab-Hamid, Norhamidar
Omar, Norsuhana
Ismail, Che Aishah Nazariah
Long, Idris
author_sort Ab-Hamid, Norhamidar
collection PubMed
description There is growing evidence that diabetes can induce cognitive decline and dementia. It is a slow, progressive cognitive decline that can occur in any age group, but is seen more frequently in older individuals. Symptoms related to cognitive decline are worsened by chronic metabolic syndrome. Animal models are frequently utilized to elucidate the mechanisms of cognitive decline in diabetes and to assess potential drugs for therapy and prevention. This review addresses the common factors and pathophysiology involved in diabetes-related cognitive decline and outlines the various animal models used to study this condition.
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spelling pubmed-102940662023-06-28 Diabetes and cognitive decline: Challenges and future direction Ab-Hamid, Norhamidar Omar, Norsuhana Ismail, Che Aishah Nazariah Long, Idris World J Diabetes Minireviews There is growing evidence that diabetes can induce cognitive decline and dementia. It is a slow, progressive cognitive decline that can occur in any age group, but is seen more frequently in older individuals. Symptoms related to cognitive decline are worsened by chronic metabolic syndrome. Animal models are frequently utilized to elucidate the mechanisms of cognitive decline in diabetes and to assess potential drugs for therapy and prevention. This review addresses the common factors and pathophysiology involved in diabetes-related cognitive decline and outlines the various animal models used to study this condition. Baishideng Publishing Group Inc 2023-06-15 2023-06-15 /pmc/articles/PMC10294066/ /pubmed/37383592 http://dx.doi.org/10.4239/wjd.v14.i6.795 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Ab-Hamid, Norhamidar
Omar, Norsuhana
Ismail, Che Aishah Nazariah
Long, Idris
Diabetes and cognitive decline: Challenges and future direction
title Diabetes and cognitive decline: Challenges and future direction
title_full Diabetes and cognitive decline: Challenges and future direction
title_fullStr Diabetes and cognitive decline: Challenges and future direction
title_full_unstemmed Diabetes and cognitive decline: Challenges and future direction
title_short Diabetes and cognitive decline: Challenges and future direction
title_sort diabetes and cognitive decline: challenges and future direction
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294066/
https://www.ncbi.nlm.nih.gov/pubmed/37383592
http://dx.doi.org/10.4239/wjd.v14.i6.795
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