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Complete Response to Enfortumab Vedotin in a Hemodialysis Patient with Metastatic Urothelial Carcinoma: A Case Report

Enfortumab vedotin (EV) is an antibody-drug conjugate and a promising agent for metastatic urothelial carcinoma (mUC). However, evaluations in end-stage renal disease patients undergoing hemodialysis are unreported. Here, we report such a case. A 74-year-old woman with mUC, on hemodialysis for compl...

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Detalles Bibliográficos
Autores principales: Isoda, Bunpei, Shiga, Masanobu, Kandori, Shuya, Nagumo, Yoshiyuki, Yoshino, Takayuki, Ikeda, Atsushi, Kawahara, Takashi, Kimura, Tomokazu, Negoro, Hiromitsu, Hoshi, Akio, Mathis, Bryan J., Nishiyama, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294212/
https://www.ncbi.nlm.nih.gov/pubmed/37384209
http://dx.doi.org/10.1159/000530780
Descripción
Sumario:Enfortumab vedotin (EV) is an antibody-drug conjugate and a promising agent for metastatic urothelial carcinoma (mUC). However, evaluations in end-stage renal disease patients undergoing hemodialysis are unreported. Here, we report such a case. A 74-year-old woman with mUC, on hemodialysis for complete urinary tract extirpation, was diagnosed with multiple pulmonary metastases after treatment with gemcitabine-carboplatin followed by pembrolizumab. As third-line therapy, she received a standard dose of EV. She achieved complete response after 2 cycles without grade 3 or higher adverse events, demonstrating the utility of EV in this setting.