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Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models

INTRODUCTION: Resistance in anti-cancer treatment is a result of clonal evolution and clonal selection. In chronic myeloid leukemia (CML), the hematopoietic neoplasm is predominantly caused by the formation of the BCR::ABL1 kinase. Evidently, treatment with tyrosine kinase inhibitors (TKIs) is treme...

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Detalles Bibliográficos
Autores principales:	Kaehler, Meike, Osteresch, Pia, Künstner, Axel, Vieth, Stella Juliane, Esser, Daniela, Möller, Marius, Busch, Hauke, Vater, Inga, Spielmann, Malte, Cascorbi, Ingolf, Nagel, Inga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294234/ https://www.ncbi.nlm.nih.gov/pubmed/37384296 http://dx.doi.org/10.3389/fonc.2023.1200897

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