Cancer stem cell fate determination: mito-nuclear communication

Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and metastasis. Therefore, clarification of the mechanisms involved in CSC stemness maintenance and cell fate determination would provide a new strategy for cancer therapy. Unregulated cellular energetics has been accepte...

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Detalles Bibliográficos
Autores principales: Fan, Mengchen, Shi, Ying, Zhao, Jumei, Li, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294499/
https://www.ncbi.nlm.nih.gov/pubmed/37370081
http://dx.doi.org/10.1186/s12964-023-01160-x
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author Fan, Mengchen
Shi, Ying
Zhao, Jumei
Li, Ling
author_facet Fan, Mengchen
Shi, Ying
Zhao, Jumei
Li, Ling
author_sort Fan, Mengchen
collection PubMed
description Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and metastasis. Therefore, clarification of the mechanisms involved in CSC stemness maintenance and cell fate determination would provide a new strategy for cancer therapy. Unregulated cellular energetics has been accepted as one of the hallmarks of cancer cells, but recent studies have revealed that mitochondrial metabolism can also actively determine CSC fate by affecting nuclear stemness gene expression. Herein, from the perspective of mito-nuclear communication, we review recent progress on the influence of mitochondria on CSC potential from four aspects: metabolism, dynamics, mitochondrial homeostasis, and reactive oxygen species (ROS). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01160-x.
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spelling pubmed-102944992023-06-28 Cancer stem cell fate determination: mito-nuclear communication Fan, Mengchen Shi, Ying Zhao, Jumei Li, Ling Cell Commun Signal Review Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and metastasis. Therefore, clarification of the mechanisms involved in CSC stemness maintenance and cell fate determination would provide a new strategy for cancer therapy. Unregulated cellular energetics has been accepted as one of the hallmarks of cancer cells, but recent studies have revealed that mitochondrial metabolism can also actively determine CSC fate by affecting nuclear stemness gene expression. Herein, from the perspective of mito-nuclear communication, we review recent progress on the influence of mitochondria on CSC potential from four aspects: metabolism, dynamics, mitochondrial homeostasis, and reactive oxygen species (ROS). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01160-x. BioMed Central 2023-06-27 /pmc/articles/PMC10294499/ /pubmed/37370081 http://dx.doi.org/10.1186/s12964-023-01160-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Fan, Mengchen
Shi, Ying
Zhao, Jumei
Li, Ling
Cancer stem cell fate determination: mito-nuclear communication
title Cancer stem cell fate determination: mito-nuclear communication
title_full Cancer stem cell fate determination: mito-nuclear communication
title_fullStr Cancer stem cell fate determination: mito-nuclear communication
title_full_unstemmed Cancer stem cell fate determination: mito-nuclear communication
title_short Cancer stem cell fate determination: mito-nuclear communication
title_sort cancer stem cell fate determination: mito-nuclear communication
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294499/
https://www.ncbi.nlm.nih.gov/pubmed/37370081
http://dx.doi.org/10.1186/s12964-023-01160-x
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