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Advances in Optogenetics Applications for Central Nervous System Injuries
Injuries to the central nervous system (CNS) often lead to severe neurological dysfunction and even death. However, there are still no effective measures to improve functional recovery following CNS injuries. Optogenetics, an ideal method to modulate neural activity, has shown various advantages in...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc., publishers
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294567/ https://www.ncbi.nlm.nih.gov/pubmed/36305381 http://dx.doi.org/10.1089/neu.2022.0290 |
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author | Geng, Yuanming Li, Zhenxing Zhu, Junhao Du, Chaonan Yuan, Feng Cai, Xiangming Ali, Alleyar Yang, Jin Tang, Chao Cong, Zixiang Ma, Chiyuan |
author_facet | Geng, Yuanming Li, Zhenxing Zhu, Junhao Du, Chaonan Yuan, Feng Cai, Xiangming Ali, Alleyar Yang, Jin Tang, Chao Cong, Zixiang Ma, Chiyuan |
author_sort | Geng, Yuanming |
collection | PubMed |
description | Injuries to the central nervous system (CNS) often lead to severe neurological dysfunction and even death. However, there are still no effective measures to improve functional recovery following CNS injuries. Optogenetics, an ideal method to modulate neural activity, has shown various advantages in controlling neural circuits, promoting neural remapping, and improving cell survival. In particular, the emerging technique of optogenetics has exhibited promising therapeutic methods for CNS injuries. In this review, we introduce the light-sensitive proteins and light stimulation system that are important components of optogenetic technology in detail and summarize the development trends. In addition, we construct a comprehensive picture of the current application of optogenetics in CNS injuries and highlight recent advances for the treatment and functional recovery of neurological deficits. Finally, we discuss the therapeutic challenges and prospective uses of optogenetics therapy by photostimulation/photoinhibition modalities that would be suitable for clinical applications. |
format | Online Article Text |
id | pubmed-10294567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Mary Ann Liebert, Inc., publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-102945672023-06-28 Advances in Optogenetics Applications for Central Nervous System Injuries Geng, Yuanming Li, Zhenxing Zhu, Junhao Du, Chaonan Yuan, Feng Cai, Xiangming Ali, Alleyar Yang, Jin Tang, Chao Cong, Zixiang Ma, Chiyuan J Neurotrauma Reviews Injuries to the central nervous system (CNS) often lead to severe neurological dysfunction and even death. However, there are still no effective measures to improve functional recovery following CNS injuries. Optogenetics, an ideal method to modulate neural activity, has shown various advantages in controlling neural circuits, promoting neural remapping, and improving cell survival. In particular, the emerging technique of optogenetics has exhibited promising therapeutic methods for CNS injuries. In this review, we introduce the light-sensitive proteins and light stimulation system that are important components of optogenetic technology in detail and summarize the development trends. In addition, we construct a comprehensive picture of the current application of optogenetics in CNS injuries and highlight recent advances for the treatment and functional recovery of neurological deficits. Finally, we discuss the therapeutic challenges and prospective uses of optogenetics therapy by photostimulation/photoinhibition modalities that would be suitable for clinical applications. Mary Ann Liebert, Inc., publishers 2023-07-01 2023-06-27 /pmc/articles/PMC10294567/ /pubmed/36305381 http://dx.doi.org/10.1089/neu.2022.0290 Text en © Yuanming Geng et al., 2023; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by-nc/4.0/This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (CC-BY-NC) (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Reviews Geng, Yuanming Li, Zhenxing Zhu, Junhao Du, Chaonan Yuan, Feng Cai, Xiangming Ali, Alleyar Yang, Jin Tang, Chao Cong, Zixiang Ma, Chiyuan Advances in Optogenetics Applications for Central Nervous System Injuries |
title | Advances in Optogenetics Applications for Central Nervous System Injuries |
title_full | Advances in Optogenetics Applications for Central Nervous System Injuries |
title_fullStr | Advances in Optogenetics Applications for Central Nervous System Injuries |
title_full_unstemmed | Advances in Optogenetics Applications for Central Nervous System Injuries |
title_short | Advances in Optogenetics Applications for Central Nervous System Injuries |
title_sort | advances in optogenetics applications for central nervous system injuries |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294567/ https://www.ncbi.nlm.nih.gov/pubmed/36305381 http://dx.doi.org/10.1089/neu.2022.0290 |
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