Location, Location, Location: an Antidote That Both Activates and Neutralizes a Toxin Used in Bacterial Warfare

S.J. Jensen, Z.C. Ruhe, A.F. Williams, D.Q. Nhan, et al. (J Bacteriol 205:e00113-23, 2023, https://doi.org/10.1128/jb.00113-23) demonstrate that a type VI secretion system (T6SS) immunity protein, Tli, functions to both neutralize and activate its cognate toxin, Tle, in Enterobacter cloacae. Their r...

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Autores principales: Ahmad, Shehryar, Whitney, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294624/
https://www.ncbi.nlm.nih.gov/pubmed/37366633
http://dx.doi.org/10.1128/jb.00161-23
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author Ahmad, Shehryar
Whitney, John C.
author_facet Ahmad, Shehryar
Whitney, John C.
author_sort Ahmad, Shehryar
collection PubMed
description S.J. Jensen, Z.C. Ruhe, A.F. Williams, D.Q. Nhan, et al. (J Bacteriol 205:e00113-23, 2023, https://doi.org/10.1128/jb.00113-23) demonstrate that a type VI secretion system (T6SS) immunity protein, Tli, functions to both neutralize and activate its cognate toxin, Tle, in Enterobacter cloacae. Their results reveal the surprising finding that Tli function differs, depending on its subcellular localization. Overall, this study enhances our understanding of T6SS immunity proteins, which are commonly viewed as monofunctional toxin-neutralizing antidotes.
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spelling pubmed-102946242023-06-28 Location, Location, Location: an Antidote That Both Activates and Neutralizes a Toxin Used in Bacterial Warfare Ahmad, Shehryar Whitney, John C. J Bacteriol Commentary S.J. Jensen, Z.C. Ruhe, A.F. Williams, D.Q. Nhan, et al. (J Bacteriol 205:e00113-23, 2023, https://doi.org/10.1128/jb.00113-23) demonstrate that a type VI secretion system (T6SS) immunity protein, Tli, functions to both neutralize and activate its cognate toxin, Tle, in Enterobacter cloacae. Their results reveal the surprising finding that Tli function differs, depending on its subcellular localization. Overall, this study enhances our understanding of T6SS immunity proteins, which are commonly viewed as monofunctional toxin-neutralizing antidotes. American Society for Microbiology 2023-05-31 /pmc/articles/PMC10294624/ /pubmed/37366633 http://dx.doi.org/10.1128/jb.00161-23 Text en Copyright © 2023 Ahmad and Whitney. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Ahmad, Shehryar
Whitney, John C.
Location, Location, Location: an Antidote That Both Activates and Neutralizes a Toxin Used in Bacterial Warfare
title Location, Location, Location: an Antidote That Both Activates and Neutralizes a Toxin Used in Bacterial Warfare
title_full Location, Location, Location: an Antidote That Both Activates and Neutralizes a Toxin Used in Bacterial Warfare
title_fullStr Location, Location, Location: an Antidote That Both Activates and Neutralizes a Toxin Used in Bacterial Warfare
title_full_unstemmed Location, Location, Location: an Antidote That Both Activates and Neutralizes a Toxin Used in Bacterial Warfare
title_short Location, Location, Location: an Antidote That Both Activates and Neutralizes a Toxin Used in Bacterial Warfare
title_sort location, location, location: an antidote that both activates and neutralizes a toxin used in bacterial warfare
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294624/
https://www.ncbi.nlm.nih.gov/pubmed/37366633
http://dx.doi.org/10.1128/jb.00161-23
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