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The Fitness of Beta-Lactamase Mutants Depends Nonlinearly on Resistance Level at Sublethal Antibiotic Concentrations

Adaptive evolutionary processes are constrained by the availability of mutations which cause a fitness benefit and together make up the fitness landscape, which maps genotype space onto fitness under specified conditions. Experimentally derived fitness landscapes have demonstrated a predictability t...

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Detalles Bibliográficos
Autores principales:	Farr, Andrew D., Pesce, Diego, Das, Suman G., Zwart, Mark P., de Visser, J. Arjan G. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294655/ https://www.ncbi.nlm.nih.gov/pubmed/37129484 http://dx.doi.org/10.1128/mbio.00098-23

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