Single-cell RNA-seq uncovers dynamic processes orchestrated by RNA-binding protein DDX43 in chromatin remodeling during spermiogenesis

Mammalian spermatogenesis shows prominent chromatin and transcriptomic switches in germ cells, but it is unclear how such dynamics are controlled. Here we identify RNA helicase DDX43 as an essential regulator of the chromatin remodeling process during spermiogenesis. Testis-specific Ddx43 knockout m...

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Detalles Bibliográficos
Autores principales: Tan, Huanhuan, Wang, Weixu, Zhou, Congjin, Wang, Yanfeng, Zhang, Shu, Yang, Pinglan, Guo, Rui, Chen, Wei, Zhang, Jinwen, Ye, Lan, Cui, Yiqiang, Ni, Ting, Zheng, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294715/
https://www.ncbi.nlm.nih.gov/pubmed/37120627
http://dx.doi.org/10.1038/s41467-023-38199-w

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