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An Initially Missed Diagnosis of Venous Thromboembolic Phenomenon in Adult-Onset Still’s Disease: A Case Report and Literature Review
Patient: Female, 43-year-old Final Diagnosis: Pulmonary venous thromboembolic phenomenon Symptoms: Hemoptysis • chest pain Clinical Procedure: Computed tomographic pulmonary angiogram (CTPA) • ventilation/perfusion (V/Q) scan Specialty: Rheumatology • Internal Medicine OBJECTIVE: Uncommon presentati...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294717/ https://www.ncbi.nlm.nih.gov/pubmed/37349977 http://dx.doi.org/10.12659/AJCR.939520 |
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author | Mankgele, Mahlatse Hlawe, Delisa Fabiano, Zayithwa Solomon, Ahmed Thomas, Riju Matyseshana, Mbali Mbakaza, Olwethu Seboka, Mpoti |
author_facet | Mankgele, Mahlatse Hlawe, Delisa Fabiano, Zayithwa Solomon, Ahmed Thomas, Riju Matyseshana, Mbali Mbakaza, Olwethu Seboka, Mpoti |
author_sort | Mankgele, Mahlatse |
collection | PubMed |
description | Patient: Female, 43-year-old Final Diagnosis: Pulmonary venous thromboembolic phenomenon Symptoms: Hemoptysis • chest pain Clinical Procedure: Computed tomographic pulmonary angiogram (CTPA) • ventilation/perfusion (V/Q) scan Specialty: Rheumatology • Internal Medicine OBJECTIVE: Uncommon presentation • Missed diagnosis BACKGROUND: Still’s disease is a rare multisystemic autoinflammatory disorder. The diagnosis of adult-onset Still’s disease (AoSD) can be challenging due to the rarity and overlapping features with many other systemic disorders. Complications of the illness can involve many systems in the human body. One of the least documented hematological complications of AoSD is thromboembolic phenomena. CASE REPORT: This text outlines the presentation of a 43-year-old woman with a known diagnosis of AoSD, whose disease-modifying anti-rheumatic drugs (DMARDs) had been tapered and stopped due to remission. She presented with respiratory symptoms and features of an AoSD flare. Lack of complete improvement on antibiotic therapy and reinitiating of DMARDs prompted seeking an alternative/concurrent diagnosis. The work-up yielded a pulmonary embolism (PE) on the background of having no other risk factors for thrombosis. CONCLUSIONS: In the reviewed literature, there is a close association between hyperferritinemia and AoSD complicated with venous thromboemboli (VTEs). A rigorous search for alternative diagnoses as well as other potential uncommon complications of AoSD is needed when working-up patients with AoSD, especially those that are not getting better on therapy. Given the rarity of AoSD, meticulous data collection may be useful in understanding the pathophysiology and features of presentation of the illness, including complications such as VTEs. |
format | Online Article Text |
id | pubmed-10294717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102947172023-06-28 An Initially Missed Diagnosis of Venous Thromboembolic Phenomenon in Adult-Onset Still’s Disease: A Case Report and Literature Review Mankgele, Mahlatse Hlawe, Delisa Fabiano, Zayithwa Solomon, Ahmed Thomas, Riju Matyseshana, Mbali Mbakaza, Olwethu Seboka, Mpoti Am J Case Rep Articles Patient: Female, 43-year-old Final Diagnosis: Pulmonary venous thromboembolic phenomenon Symptoms: Hemoptysis • chest pain Clinical Procedure: Computed tomographic pulmonary angiogram (CTPA) • ventilation/perfusion (V/Q) scan Specialty: Rheumatology • Internal Medicine OBJECTIVE: Uncommon presentation • Missed diagnosis BACKGROUND: Still’s disease is a rare multisystemic autoinflammatory disorder. The diagnosis of adult-onset Still’s disease (AoSD) can be challenging due to the rarity and overlapping features with many other systemic disorders. Complications of the illness can involve many systems in the human body. One of the least documented hematological complications of AoSD is thromboembolic phenomena. CASE REPORT: This text outlines the presentation of a 43-year-old woman with a known diagnosis of AoSD, whose disease-modifying anti-rheumatic drugs (DMARDs) had been tapered and stopped due to remission. She presented with respiratory symptoms and features of an AoSD flare. Lack of complete improvement on antibiotic therapy and reinitiating of DMARDs prompted seeking an alternative/concurrent diagnosis. The work-up yielded a pulmonary embolism (PE) on the background of having no other risk factors for thrombosis. CONCLUSIONS: In the reviewed literature, there is a close association between hyperferritinemia and AoSD complicated with venous thromboemboli (VTEs). A rigorous search for alternative diagnoses as well as other potential uncommon complications of AoSD is needed when working-up patients with AoSD, especially those that are not getting better on therapy. Given the rarity of AoSD, meticulous data collection may be useful in understanding the pathophysiology and features of presentation of the illness, including complications such as VTEs. International Scientific Literature, Inc. 2023-06-23 /pmc/articles/PMC10294717/ /pubmed/37349977 http://dx.doi.org/10.12659/AJCR.939520 Text en © Am J Case Rep, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Mankgele, Mahlatse Hlawe, Delisa Fabiano, Zayithwa Solomon, Ahmed Thomas, Riju Matyseshana, Mbali Mbakaza, Olwethu Seboka, Mpoti An Initially Missed Diagnosis of Venous Thromboembolic Phenomenon in Adult-Onset Still’s Disease: A Case Report and Literature Review |
title | An Initially Missed Diagnosis of Venous Thromboembolic Phenomenon in Adult-Onset Still’s Disease: A Case Report and Literature Review |
title_full | An Initially Missed Diagnosis of Venous Thromboembolic Phenomenon in Adult-Onset Still’s Disease: A Case Report and Literature Review |
title_fullStr | An Initially Missed Diagnosis of Venous Thromboembolic Phenomenon in Adult-Onset Still’s Disease: A Case Report and Literature Review |
title_full_unstemmed | An Initially Missed Diagnosis of Venous Thromboembolic Phenomenon in Adult-Onset Still’s Disease: A Case Report and Literature Review |
title_short | An Initially Missed Diagnosis of Venous Thromboembolic Phenomenon in Adult-Onset Still’s Disease: A Case Report and Literature Review |
title_sort | initially missed diagnosis of venous thromboembolic phenomenon in adult-onset still’s disease: a case report and literature review |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294717/ https://www.ncbi.nlm.nih.gov/pubmed/37349977 http://dx.doi.org/10.12659/AJCR.939520 |
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