Cargando…

Therapeutic Potential of Heterocyclic Compounds Targeting Mitochondrial Calcium Homeostasis and Signaling in Alzheimer’s Disease and Parkinson’s Disease

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative diseases in the elderly. The key histopathological features of these diseases are the presence of abnormal protein aggregates and the progressive and irreversible loss of neurons in specific brain regions...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tapias, Victor, González-Andrés, Paula, Peña, Laura F., Barbero, Asunción, Núñez, Lucía, Villalobos, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294814/ https://www.ncbi.nlm.nih.gov/pubmed/37372013 http://dx.doi.org/10.3390/antiox12061282

Ejemplares similares

Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches
por: González-Andrés, Paula, et al.
Publicado: (2021)

The Role of Mitochondrial Calcium Homeostasis in Alzheimer’s and Related Diseases
por: Ryan, Kerry C., et al.
Publicado: (2020)

Role of Calcium Homeostasis in Alzheimer’s Disease
por: Ge, Mengqian, et al.
Publicado: (2022)

Mitochondrial Homeostasis and Signaling in Parkinson’s Disease
por: Scorziello, Antonella, et al.
Publicado: (2020)

Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease
por: Hoekstra, Jake G, et al.
Publicado: (2011)

Heterocyclic compounds as key structures for the interaction with old and new targets in Alzheimer’s disease therapy
por: Hiremathad, Asha, et al.
Publicado: (2017)

Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson's Disease
por: Yang, Ruixin, et al.
Publicado: (2016)

Mitochondrial homeostasis in Parkinson’s disease - a triumvirate rule?
por: Ng, Chee-Hoe, et al.
Publicado: (2017)

L-Ornithine L-Aspartate Restores Mitochondrial Function and Modulates Intracellular Calcium Homeostasis in Parkinson’s Disease Models
por: Sisalli, Maria Josè, et al.
Publicado: (2022)

Maintenance of mitochondrial homeostasis for Alzheimer's disease: Strategies and challenges
por: Han, Ying, et al.
Publicado: (2023)

Effects of Redox Homeostasis and Mitochondrial Damage on Alzheimer’s Disease
por: Wu, Yi-Hsuan, et al.
Publicado: (2023)

Changing the Reaction Pathway of Silyl-Prins Cyclization by Switching the Lewis Acid: Application to the Synthesis of an Antinociceptive Compound
por: Díez-Poza, Carlos, et al.
Publicado: (2023)

Calcium Signaling Regulated by Cellular Membrane Systems and Calcium Homeostasis Perturbed in Alzheimer’s Disease
por: Huang, Dong-Xu, et al.
Publicado: (2022)

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
por: Dölle, Christian, et al.
Publicado: (2016)

Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease
por: Vizziello, Maria, et al.
Publicado: (2021)

Heterocyclic compounds /
Publicado: (1950)

Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease
por: Honarnejad, Kamran, et al.
Publicado: (2013)

Mitochondria-Targeted Protective Compounds in Parkinson's and Alzheimer's Diseases
por: Fernández-Moriano, Carlos, et al.
Publicado: (2015)

Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease
por: Bagán, Andrea, et al.
Publicado: (2023)

Mutations in RHOT1 Disrupt Endoplasmic Reticulum–Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease
por: Grossmann, Dajana, et al.
Publicado: (2019)

Measuring Compounds in Exhaled Air to Detect Alzheimer's Disease and Parkinson’s Disease
por: Bach, Jan-Philipp, et al.
Publicado: (2015)

Rare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer’s Disease Patients Alter Calcium Homeostasis
por: Rubio-Moscardo, Fanny, et al.
Publicado: (2013)

A Glimmer of Hope: Maintain Mitochondrial Homeostasis to Mitigate Alzheimer’s Disease
por: Li, Wenbo, et al.
Publicado: (2020)

GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease
por: Xu, Peng, et al.
Publicado: (2021)

Mitochondrial calcium homeostasis as potential target for mitochondrial medicine
por: Giorgi, Carlotta, et al.
Publicado: (2012)

Impact of halogenated compounds on calcium homeostasis in hepatocytes.
por: Moore, L, et al.
Publicado: (1990)

Role of Toll Like Receptor 4 in Alzheimer’s Disease
por: Calvo-Rodriguez, Maria, et al.
Publicado: (2020)

Mitochondrial Homeostasis Molecules: Regulation by a Trio of Recessive Parkinson's Disease Genes
por: Han, Ji-Young, et al.
Publicado: (2014)

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
por: Jadiya, Pooja, et al.
Publicado: (2019)

Phenothiazine normalizes the NADH/NAD(+) ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone model of Parkinson's disease
por: Tapias, Victor, et al.
Publicado: (2019)

Alzheimer’s Disease: From Immune Homeostasis to Neuroinflammatory Condition
por: Princiotta Cariddi, Lucia, et al.
Publicado: (2022)

Mitochondrial dysfunction: A notable contributor to the progression of Alzheimer's and Parkinson's disease
por: Olagunju, Abolaji Samson, et al.
Publicado: (2023)

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer’s disease and Parkinson’s disease
por: Ganguly, Gargi, et al.
Publicado: (2017)

Excitatory Dendritic Mitochondrial Calcium Toxicity: Implications for Parkinson’s and Other Neurodegenerative Diseases
por: Verma, Manish, et al.
Publicado: (2018)

m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration
por: Patron, Maria, et al.
Publicado: (2018)

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease
por: Yang, Yun, et al.
Publicado: (2022)

Calcium, Bioenergetics, and Parkinson’s Disease
por: Zampese, Enrico, et al.
Publicado: (2020)

On the Chemical and Biological Characteristics of Multifunctional Compounds for the Treatment of Parkinson’s Disease
por: García-Beltrán, Olimpo, et al.
Publicado: (2023)

High mitochondrial calcium levels precede neuronal death in vivo in Alzheimer's disease
por: Calvo-Rodriguez, Maria, et al.
Publicado: (2020)

Protein Homeostasis, Aging and Alzheimer’s Disease
por: Morawe, Tobias, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_3t61gpo0gjr69bgmeefcgt49t9