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Bacterial Species and Antibiotic Resistance—A Retrospective Analysis of Bacterial Cultures in a Pediatric Hospital

Antimicrobial resistance (AMR) has become a major healthcare concern having a rising incidence, especially in pediatric patients who are more susceptible to infections. The aim of our study was to analyze the bacterial species isolated from patients admitted to our tertiary hospital and their AMR pr...

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Autores principales: Prajescu, Bianca, Gavriliu, Liana, Iesanu, Mara Ioana, Ioan, Andreea, Boboc, Anca Andreea, Boboc, Catalin, Galos, Felicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294880/
https://www.ncbi.nlm.nih.gov/pubmed/37370285
http://dx.doi.org/10.3390/antibiotics12060966
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author Prajescu, Bianca
Gavriliu, Liana
Iesanu, Mara Ioana
Ioan, Andreea
Boboc, Anca Andreea
Boboc, Catalin
Galos, Felicia
author_facet Prajescu, Bianca
Gavriliu, Liana
Iesanu, Mara Ioana
Ioan, Andreea
Boboc, Anca Andreea
Boboc, Catalin
Galos, Felicia
author_sort Prajescu, Bianca
collection PubMed
description Antimicrobial resistance (AMR) has become a major healthcare concern having a rising incidence, especially in pediatric patients who are more susceptible to infections. The aim of our study was to analyze the bacterial species isolated from patients admitted to our tertiary hospital and their AMR profiles. We conducted a retrospective observational study by examining the bacterial cultures collected from pediatric patients admitted to our hospital over a period of one year. We identified the most common bacterial species from 1445 clinical isolates and their AMR patterns using standard microbiological techniques. Our analysis revealed that the most frequently isolated bacterial species were Escherichia coli (23.73%), Staphylococcus aureus (15.64%), Klebsiella species (12.04%), and Pseudomonas species (9.96%). Additionally, these species exhibited varying levels of resistance to commonly used antibiotics. Notably, we observed high rates of resistance among Gram-negative bacteria, including extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species. Among Gram-positive bacteria, we observed a high level of methicillin-resistant Staphylococcus aureus. Our findings highlight the urgent need for effective antibiotic management programs and infection control measures to address the rising incidence of AMR in pediatric hospitals. Further research is needed to identify the mechanisms of resistance in these bacterial species and to develop new strategies for preventing and treating infections caused by antibiotic-resistant bacteria in pediatric patients.
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spelling pubmed-102948802023-06-28 Bacterial Species and Antibiotic Resistance—A Retrospective Analysis of Bacterial Cultures in a Pediatric Hospital Prajescu, Bianca Gavriliu, Liana Iesanu, Mara Ioana Ioan, Andreea Boboc, Anca Andreea Boboc, Catalin Galos, Felicia Antibiotics (Basel) Article Antimicrobial resistance (AMR) has become a major healthcare concern having a rising incidence, especially in pediatric patients who are more susceptible to infections. The aim of our study was to analyze the bacterial species isolated from patients admitted to our tertiary hospital and their AMR profiles. We conducted a retrospective observational study by examining the bacterial cultures collected from pediatric patients admitted to our hospital over a period of one year. We identified the most common bacterial species from 1445 clinical isolates and their AMR patterns using standard microbiological techniques. Our analysis revealed that the most frequently isolated bacterial species were Escherichia coli (23.73%), Staphylococcus aureus (15.64%), Klebsiella species (12.04%), and Pseudomonas species (9.96%). Additionally, these species exhibited varying levels of resistance to commonly used antibiotics. Notably, we observed high rates of resistance among Gram-negative bacteria, including extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species. Among Gram-positive bacteria, we observed a high level of methicillin-resistant Staphylococcus aureus. Our findings highlight the urgent need for effective antibiotic management programs and infection control measures to address the rising incidence of AMR in pediatric hospitals. Further research is needed to identify the mechanisms of resistance in these bacterial species and to develop new strategies for preventing and treating infections caused by antibiotic-resistant bacteria in pediatric patients. MDPI 2023-05-26 /pmc/articles/PMC10294880/ /pubmed/37370285 http://dx.doi.org/10.3390/antibiotics12060966 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Prajescu, Bianca
Gavriliu, Liana
Iesanu, Mara Ioana
Ioan, Andreea
Boboc, Anca Andreea
Boboc, Catalin
Galos, Felicia
Bacterial Species and Antibiotic Resistance—A Retrospective Analysis of Bacterial Cultures in a Pediatric Hospital
title Bacterial Species and Antibiotic Resistance—A Retrospective Analysis of Bacterial Cultures in a Pediatric Hospital
title_full Bacterial Species and Antibiotic Resistance—A Retrospective Analysis of Bacterial Cultures in a Pediatric Hospital
title_fullStr Bacterial Species and Antibiotic Resistance—A Retrospective Analysis of Bacterial Cultures in a Pediatric Hospital
title_full_unstemmed Bacterial Species and Antibiotic Resistance—A Retrospective Analysis of Bacterial Cultures in a Pediatric Hospital
title_short Bacterial Species and Antibiotic Resistance—A Retrospective Analysis of Bacterial Cultures in a Pediatric Hospital
title_sort bacterial species and antibiotic resistance—a retrospective analysis of bacterial cultures in a pediatric hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294880/
https://www.ncbi.nlm.nih.gov/pubmed/37370285
http://dx.doi.org/10.3390/antibiotics12060966
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