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Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer

To investigate whether parameters from IDEAL-IQ/amide proton transfer MRI (APTWI) could help predict histopathological factors of rectal cancer. Preoperative IDEAL-IQ and APTWI sequences of 67 patients with rectal cancer were retrospectively analyzed. The intra-tumoral proton density fat fraction (P...

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Autores principales: Peng, Yang, Zou, Xianlun, Chen, Gen, Hu, Xuemei, Shen, Yaqi, Hu, Daoyu, Li, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294893/
https://www.ncbi.nlm.nih.gov/pubmed/37370651
http://dx.doi.org/10.3390/bioengineering10060720
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author Peng, Yang
Zou, Xianlun
Chen, Gen
Hu, Xuemei
Shen, Yaqi
Hu, Daoyu
Li, Zhen
author_facet Peng, Yang
Zou, Xianlun
Chen, Gen
Hu, Xuemei
Shen, Yaqi
Hu, Daoyu
Li, Zhen
author_sort Peng, Yang
collection PubMed
description To investigate whether parameters from IDEAL-IQ/amide proton transfer MRI (APTWI) could help predict histopathological factors of rectal cancer. Preoperative IDEAL-IQ and APTWI sequences of 67 patients with rectal cancer were retrospectively analyzed. The intra-tumoral proton density fat fraction (PDFF), R2* and magnetization transfer ratio asymmetry (MTRasym (3.5 ppm)) were measured according to the histopathological factors of rectal cancer. The relationship between MR parameters and histopathological factors were analyzed, along with diagnostic performance of MR parameters. PDFF, R2* and MTRasym (3.5 ppm) were statistically different between T1+T2/T3+T4 stages, non-metastatic/metastatic lymph nodes, lower/higher tumor grade and negative/positive status of MRF and EMVI (p < 0.001 for PDFF, p = 0.000–0.015 for R2* and p = 0.000–0.006 for MTRasym (3.5 ppm)). There were positive correlations between the above parameters and the histopathological features of rectal cancer (r = 0.464–0.723 for PDFF (p < 0.001), 0.299–0.651 for R2* (p = 0.000–0.014), and 0.337–0.667 for MTRasym (3.5 ppm) (p = 0.000–0.005)). MTRasym (3.5 ppm) correlated moderately and mildly with PDFF (r = 0.563, p < 0.001) and R2* (r = 0.335, p = 0.006), respectively. PDFF provided a significantly higher diagnostic ability than MTRasym (3.5 ppm) for distinguishing metastatic from non-metastatic lymph nodes (z = 2.407, p = 0.0161). No significant differences were found in MR parameters for distinguishing other histopathological features (p > 0.05). IDEAL-IQ and APTWI were associated with histopathological factors of rectal cancer, and might serve as non-invasive biomarkers for characterizing rectal cancer.
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spelling pubmed-102948932023-06-28 Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer Peng, Yang Zou, Xianlun Chen, Gen Hu, Xuemei Shen, Yaqi Hu, Daoyu Li, Zhen Bioengineering (Basel) Article To investigate whether parameters from IDEAL-IQ/amide proton transfer MRI (APTWI) could help predict histopathological factors of rectal cancer. Preoperative IDEAL-IQ and APTWI sequences of 67 patients with rectal cancer were retrospectively analyzed. The intra-tumoral proton density fat fraction (PDFF), R2* and magnetization transfer ratio asymmetry (MTRasym (3.5 ppm)) were measured according to the histopathological factors of rectal cancer. The relationship between MR parameters and histopathological factors were analyzed, along with diagnostic performance of MR parameters. PDFF, R2* and MTRasym (3.5 ppm) were statistically different between T1+T2/T3+T4 stages, non-metastatic/metastatic lymph nodes, lower/higher tumor grade and negative/positive status of MRF and EMVI (p < 0.001 for PDFF, p = 0.000–0.015 for R2* and p = 0.000–0.006 for MTRasym (3.5 ppm)). There were positive correlations between the above parameters and the histopathological features of rectal cancer (r = 0.464–0.723 for PDFF (p < 0.001), 0.299–0.651 for R2* (p = 0.000–0.014), and 0.337–0.667 for MTRasym (3.5 ppm) (p = 0.000–0.005)). MTRasym (3.5 ppm) correlated moderately and mildly with PDFF (r = 0.563, p < 0.001) and R2* (r = 0.335, p = 0.006), respectively. PDFF provided a significantly higher diagnostic ability than MTRasym (3.5 ppm) for distinguishing metastatic from non-metastatic lymph nodes (z = 2.407, p = 0.0161). No significant differences were found in MR parameters for distinguishing other histopathological features (p > 0.05). IDEAL-IQ and APTWI were associated with histopathological factors of rectal cancer, and might serve as non-invasive biomarkers for characterizing rectal cancer. MDPI 2023-06-14 /pmc/articles/PMC10294893/ /pubmed/37370651 http://dx.doi.org/10.3390/bioengineering10060720 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peng, Yang
Zou, Xianlun
Chen, Gen
Hu, Xuemei
Shen, Yaqi
Hu, Daoyu
Li, Zhen
Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer
title Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer
title_full Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer
title_fullStr Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer
title_full_unstemmed Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer
title_short Chemical Shift-Encoded Sequence (IDEAL-IQ) and Amide Proton Transfer (APT) MRI for Prediction of Histopathological Factors of Rectal Cancer
title_sort chemical shift-encoded sequence (ideal-iq) and amide proton transfer (apt) mri for prediction of histopathological factors of rectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294893/
https://www.ncbi.nlm.nih.gov/pubmed/37370651
http://dx.doi.org/10.3390/bioengineering10060720
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