Cargando…

Nrf2 as a Therapeutic Target in the Resistance to Targeted Therapies in Melanoma

The use of specific inhibitors towards mutant BRAF (BRAFi) and MEK (MEKi) in BRAF-mutated patients has significantly improved progression-free and overall survival of metastatic melanoma patients. Nevertheless, half of the patients still develop resistance within the first year of therapy. Therefore...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cucci, Marie Angèle, Grattarola, Margherita, Monge, Chiara, Roetto, Antonella, Barrera, Giuseppina, Caputo, Emilia, Dianzani, Chiara, Pizzimenti, Stefania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294952/ https://www.ncbi.nlm.nih.gov/pubmed/37372043 http://dx.doi.org/10.3390/antiox12061313

Ejemplares similares

Oxidative Stress-Related Mechanisms in Melanoma and in the Acquired Resistance to Targeted Therapies
por: Pizzimenti, Stefania, et al.
Publicado: (2021)

Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role
por: Barrera, Giuseppina, et al.
Publicado: (2021)

Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma
por: Argenziano, Monica, et al.
Publicado: (2022)

Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle
por: Azzimonti, Barbara, et al.
Publicado: (2023)

Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells
por: Ambrosio, Leanne, et al.
Publicado: (2020)

Surface Functionalised Parenteral Nanoemulsions for Active and Homotypic Targeting to Melanoma
por: Foglietta, Federica, et al.
Publicado: (2023)

Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders
por: Barrera, Giuseppina, et al.
Publicado: (2018)

Exploiting Nanomedicine for Cancer Polychemotherapy: Recent Advances and Clinical Applications
por: Boggio, Elena, et al.
Publicado: (2023)

Parenteral Nanoemulsions Loaded with Combined Immuno- and Chemo-Therapy for Melanoma Treatment
por: Monge, Chiara, et al.
Publicado: (2022)

Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells
por: Girek, Małgorzata, et al.
Publicado: (2019)

Paclitaxel-Loaded Nanosponges Inhibit Growth and Angiogenesis in Melanoma Cell Models
por: Clemente, Nausicaa, et al.
Publicado: (2019)

MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities
por: Sequera, Celia, et al.
Publicado: (2022)

The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer
por: Pizzimenti, Stefania, et al.
Publicado: (2010)

Rosiglitazone and AS601245 Decrease Cell Adhesion and Migration through Modulation of Specific Gene Expression in Human Colon Cancer Cells
por: Cerbone, Angelo, et al.
Publicado: (2012)

AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells
por: Cerbone, Angelo, et al.
Publicado: (2012)

Improvement in the Anti-Tumor Efficacy of Doxorubicin Nanosponges in In Vitro and in Mice Bearing Breast Tumor Models
por: Argenziano, Monica, et al.
Publicado: (2020)

The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products
por: Barrera, Giuseppina, et al.
Publicado: (2008)

Interaction of aldehydes derived from lipid peroxidation and membrane proteins
por: Pizzimenti, Stefania, et al.
Publicado: (2013)

Drug Delivery Nanoparticles in Skin Cancers
por: Dianzani, Chiara, et al.
Publicado: (2014)

DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity
por: Gentile, Fabrizio, et al.
Publicado: (2017)

Corrigendum to “Drug Delivery Nanoparticles in Skin Cancers”
por: Dianzani, Chiara, et al.
Publicado: (2021)

Mitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation Products
por: Barrera, Giuseppina, et al.
Publicado: (2016)

Nanoemulsions as Delivery Systems for Poly-Chemotherapy Aiming at Melanoma Treatment
por: Dianzani, Chiara, et al.
Publicado: (2020)

Peroxisome Proliferator-Activated Receptors (PPARs) and Oxidative Stress in Physiological Conditions and in Cancer
por: Muzio, Giuliana, et al.
Publicado: (2021)

NRF2 as an Emerging Therapeutic Target
por: Copple, Ian M., et al.
Publicado: (2017)

Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells in vitro and in vivo on orthotopic xenograft tumors
por: Gigliotti, Casimiro Luca, et al.
Publicado: (2017)

Targeted therapeutics in melanoma
por: Ali, Z, et al.
Publicado: (2012)

Inducible T-Cell Costimulator Ligand Plays a Dual Role in Melanoma Metastasis upon Binding to Osteopontin or Inducible T-Cell Costimulator
por: Raineri, Davide, et al.
Publicado: (2021)

NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation
por: Carpenter, Evan L., et al.
Publicado: (2022)

PPARγ ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells
por: Toaldo, Cristina, et al.
Publicado: (2010)

Overview of Nrf2 as Therapeutic Target in Epilepsy
por: Carmona-Aparicio, Liliana, et al.
Publicado: (2015)

The Functional Versatility of Transferrin Receptor 2 and Its Therapeutic Value
por: Roetto, Antonella, et al.
Publicado: (2018)

Pathways and therapeutic targets in melanoma
por: Shtivelman, Emma, et al.
Publicado: (2014)

Novel Therapeutic Targets in Melanoma
por: Cerezo, Michaël, et al.
Publicado: (2023)

Nrf2 activation as target to implement therapeutic treatments
por: Bocci, Velio, et al.
Publicado: (2015)

Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases
por: Nakagami, Yasuhiro
Publicado: (2016)

NRF2 as a Therapeutic Target in Neurodegenerative Diseases
por: Brandes, Mikah S., et al.
Publicado: (2020)

Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer
por: Telkoparan-Akillilar, Pelin, et al.
Publicado: (2021)

Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease
por: Pascale, Emilia, et al.
Publicado: (2020)

Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis
por: Neuendorf, Hannah M., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m7f0qc0spmd8b6hhf99odj4ta9