Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice

This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%)...

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Autores principales: Barbosa-de-Oliveira, Maria Clara, Oliveira-Melo, Paolo, Gonçalves da Silva, Marcos Henrique, Santos da Silva, Flávio, Andrade Carvalho da Silva, Felipe, Silva de Araujo, Bruno Vinicios, Franco de Oliveira, Moacir, Tadeu Correia, Aristides, Miyoshi Sakamoto, Sidnei, Valença, Samuel Santos, Lanzetti, Manuella, Schmidt, Martina, Kennedy-Feitosa, Emanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294992/
https://www.ncbi.nlm.nih.gov/pubmed/37371988
http://dx.doi.org/10.3390/antiox12061258
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author Barbosa-de-Oliveira, Maria Clara
Oliveira-Melo, Paolo
Gonçalves da Silva, Marcos Henrique
Santos da Silva, Flávio
Andrade Carvalho da Silva, Felipe
Silva de Araujo, Bruno Vinicios
Franco de Oliveira, Moacir
Tadeu Correia, Aristides
Miyoshi Sakamoto, Sidnei
Valença, Samuel Santos
Lanzetti, Manuella
Schmidt, Martina
Kennedy-Feitosa, Emanuel
author_facet Barbosa-de-Oliveira, Maria Clara
Oliveira-Melo, Paolo
Gonçalves da Silva, Marcos Henrique
Santos da Silva, Flávio
Andrade Carvalho da Silva, Felipe
Silva de Araujo, Bruno Vinicios
Franco de Oliveira, Moacir
Tadeu Correia, Aristides
Miyoshi Sakamoto, Sidnei
Valença, Samuel Santos
Lanzetti, Manuella
Schmidt, Martina
Kennedy-Feitosa, Emanuel
author_sort Barbosa-de-Oliveira, Maria Clara
collection PubMed
description This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.
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spelling pubmed-102949922023-06-28 Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice Barbosa-de-Oliveira, Maria Clara Oliveira-Melo, Paolo Gonçalves da Silva, Marcos Henrique Santos da Silva, Flávio Andrade Carvalho da Silva, Felipe Silva de Araujo, Bruno Vinicios Franco de Oliveira, Moacir Tadeu Correia, Aristides Miyoshi Sakamoto, Sidnei Valença, Samuel Santos Lanzetti, Manuella Schmidt, Martina Kennedy-Feitosa, Emanuel Antioxidants (Basel) Article This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity. MDPI 2023-06-11 /pmc/articles/PMC10294992/ /pubmed/37371988 http://dx.doi.org/10.3390/antiox12061258 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barbosa-de-Oliveira, Maria Clara
Oliveira-Melo, Paolo
Gonçalves da Silva, Marcos Henrique
Santos da Silva, Flávio
Andrade Carvalho da Silva, Felipe
Silva de Araujo, Bruno Vinicios
Franco de Oliveira, Moacir
Tadeu Correia, Aristides
Miyoshi Sakamoto, Sidnei
Valença, Samuel Santos
Lanzetti, Manuella
Schmidt, Martina
Kennedy-Feitosa, Emanuel
Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice
title Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice
title_full Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice
title_fullStr Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice
title_full_unstemmed Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice
title_short Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice
title_sort modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294992/
https://www.ncbi.nlm.nih.gov/pubmed/37371988
http://dx.doi.org/10.3390/antiox12061258
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