Cargando…
Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities
A new type of fibrous mat based on a cellulose derivative—cellulose acetate (CA) or CA and water-soluble polymers (polyvinylpyrrolidone, PVP or poly(vinyl alcohol), PVA)—loaded with the model drug 5-nitro-8-hydroxyquinoline (5N) was fabricated via electrospinning or electrospinning in conjunction wi...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295047/ https://www.ncbi.nlm.nih.gov/pubmed/37371973 http://dx.doi.org/10.3390/antiox12061243 |
_version_ | 1785063327524716544 |
---|---|
author | Spasova, Mariya Stoyanova, Nikoleta Nachev, Nasko Ignatova, Milena Manolova, Nevena Rashkov, Iliya Georgieva, Ani Toshkova, Reneta Markova, Nadya |
author_facet | Spasova, Mariya Stoyanova, Nikoleta Nachev, Nasko Ignatova, Milena Manolova, Nevena Rashkov, Iliya Georgieva, Ani Toshkova, Reneta Markova, Nadya |
author_sort | Spasova, Mariya |
collection | PubMed |
description | A new type of fibrous mat based on a cellulose derivative—cellulose acetate (CA) or CA and water-soluble polymers (polyvinylpyrrolidone, PVP or poly(vinyl alcohol), PVA)—loaded with the model drug 5-nitro-8-hydroxyquinoline (5N) was fabricated via electrospinning or electrospinning in conjunction with electrospraying. Scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FTIR), water contact angle measurements and ultraviolet-visible spectroscopy (UV-Vis) were used for the complex characterization of the obtained novel material. The decoration of CA fibers with a water-soluble polymer containing the drug resulted in the facilitation of wetting and fast drug release. The 5N-containing fibrous material showed antioxidant activity. Moreover, the proposed materials’ antibacterial and antifungal properties were tested against S. aureus, E. coli, P. aeruginosa and C. albicans. Well-distinguished, sterile zones with diameters above 3.5 cm were observed around all 5N-containing mats. The mats’ cytotoxicity toward HeLa carcinoma cells and normal mouse BALB/c 3T3 fibroblasts was assessed. The 5N-in-CA, PVP,5N-on-(5N-in-CA) and PVA,5N-on-(5N-in-CA) fibrous mats possessed anticancer efficacies and much lower levels of toxicity against normal cells. Therefore, the as-created novel electrospun materials, which are based on polymers loaded with the drug 5N via electrospinning/electrospraying, can potentially be applied for topical wound healing and for local cancer therapy. |
format | Online Article Text |
id | pubmed-10295047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102950472023-06-28 Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities Spasova, Mariya Stoyanova, Nikoleta Nachev, Nasko Ignatova, Milena Manolova, Nevena Rashkov, Iliya Georgieva, Ani Toshkova, Reneta Markova, Nadya Antioxidants (Basel) Article A new type of fibrous mat based on a cellulose derivative—cellulose acetate (CA) or CA and water-soluble polymers (polyvinylpyrrolidone, PVP or poly(vinyl alcohol), PVA)—loaded with the model drug 5-nitro-8-hydroxyquinoline (5N) was fabricated via electrospinning or electrospinning in conjunction with electrospraying. Scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FTIR), water contact angle measurements and ultraviolet-visible spectroscopy (UV-Vis) were used for the complex characterization of the obtained novel material. The decoration of CA fibers with a water-soluble polymer containing the drug resulted in the facilitation of wetting and fast drug release. The 5N-containing fibrous material showed antioxidant activity. Moreover, the proposed materials’ antibacterial and antifungal properties were tested against S. aureus, E. coli, P. aeruginosa and C. albicans. Well-distinguished, sterile zones with diameters above 3.5 cm were observed around all 5N-containing mats. The mats’ cytotoxicity toward HeLa carcinoma cells and normal mouse BALB/c 3T3 fibroblasts was assessed. The 5N-in-CA, PVP,5N-on-(5N-in-CA) and PVA,5N-on-(5N-in-CA) fibrous mats possessed anticancer efficacies and much lower levels of toxicity against normal cells. Therefore, the as-created novel electrospun materials, which are based on polymers loaded with the drug 5N via electrospinning/electrospraying, can potentially be applied for topical wound healing and for local cancer therapy. MDPI 2023-06-09 /pmc/articles/PMC10295047/ /pubmed/37371973 http://dx.doi.org/10.3390/antiox12061243 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Spasova, Mariya Stoyanova, Nikoleta Nachev, Nasko Ignatova, Milena Manolova, Nevena Rashkov, Iliya Georgieva, Ani Toshkova, Reneta Markova, Nadya Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities |
title | Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities |
title_full | Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities |
title_fullStr | Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities |
title_full_unstemmed | Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities |
title_short | Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities |
title_sort | innovative fibrous materials loaded with 5-nitro-8-hydroxyquinoline via electrospinning/electrospraying demonstrate antioxidant, antimicrobial and anticancer activities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295047/ https://www.ncbi.nlm.nih.gov/pubmed/37371973 http://dx.doi.org/10.3390/antiox12061243 |
work_keys_str_mv | AT spasovamariya innovativefibrousmaterialsloadedwith5nitro8hydroxyquinolineviaelectrospinningelectrosprayingdemonstrateantioxidantantimicrobialandanticanceractivities AT stoyanovanikoleta innovativefibrousmaterialsloadedwith5nitro8hydroxyquinolineviaelectrospinningelectrosprayingdemonstrateantioxidantantimicrobialandanticanceractivities AT nachevnasko innovativefibrousmaterialsloadedwith5nitro8hydroxyquinolineviaelectrospinningelectrosprayingdemonstrateantioxidantantimicrobialandanticanceractivities AT ignatovamilena innovativefibrousmaterialsloadedwith5nitro8hydroxyquinolineviaelectrospinningelectrosprayingdemonstrateantioxidantantimicrobialandanticanceractivities AT manolovanevena innovativefibrousmaterialsloadedwith5nitro8hydroxyquinolineviaelectrospinningelectrosprayingdemonstrateantioxidantantimicrobialandanticanceractivities AT rashkoviliya innovativefibrousmaterialsloadedwith5nitro8hydroxyquinolineviaelectrospinningelectrosprayingdemonstrateantioxidantantimicrobialandanticanceractivities AT georgievaani innovativefibrousmaterialsloadedwith5nitro8hydroxyquinolineviaelectrospinningelectrosprayingdemonstrateantioxidantantimicrobialandanticanceractivities AT toshkovareneta innovativefibrousmaterialsloadedwith5nitro8hydroxyquinolineviaelectrospinningelectrosprayingdemonstrateantioxidantantimicrobialandanticanceractivities AT markovanadya innovativefibrousmaterialsloadedwith5nitro8hydroxyquinolineviaelectrospinningelectrosprayingdemonstrateantioxidantantimicrobialandanticanceractivities |