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Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities

A new type of fibrous mat based on a cellulose derivative—cellulose acetate (CA) or CA and water-soluble polymers (polyvinylpyrrolidone, PVP or poly(vinyl alcohol), PVA)—loaded with the model drug 5-nitro-8-hydroxyquinoline (5N) was fabricated via electrospinning or electrospinning in conjunction wi...

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Autores principales: Spasova, Mariya, Stoyanova, Nikoleta, Nachev, Nasko, Ignatova, Milena, Manolova, Nevena, Rashkov, Iliya, Georgieva, Ani, Toshkova, Reneta, Markova, Nadya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295047/
https://www.ncbi.nlm.nih.gov/pubmed/37371973
http://dx.doi.org/10.3390/antiox12061243
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author Spasova, Mariya
Stoyanova, Nikoleta
Nachev, Nasko
Ignatova, Milena
Manolova, Nevena
Rashkov, Iliya
Georgieva, Ani
Toshkova, Reneta
Markova, Nadya
author_facet Spasova, Mariya
Stoyanova, Nikoleta
Nachev, Nasko
Ignatova, Milena
Manolova, Nevena
Rashkov, Iliya
Georgieva, Ani
Toshkova, Reneta
Markova, Nadya
author_sort Spasova, Mariya
collection PubMed
description A new type of fibrous mat based on a cellulose derivative—cellulose acetate (CA) or CA and water-soluble polymers (polyvinylpyrrolidone, PVP or poly(vinyl alcohol), PVA)—loaded with the model drug 5-nitro-8-hydroxyquinoline (5N) was fabricated via electrospinning or electrospinning in conjunction with electrospraying. Scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FTIR), water contact angle measurements and ultraviolet-visible spectroscopy (UV-Vis) were used for the complex characterization of the obtained novel material. The decoration of CA fibers with a water-soluble polymer containing the drug resulted in the facilitation of wetting and fast drug release. The 5N-containing fibrous material showed antioxidant activity. Moreover, the proposed materials’ antibacterial and antifungal properties were tested against S. aureus, E. coli, P. aeruginosa and C. albicans. Well-distinguished, sterile zones with diameters above 3.5 cm were observed around all 5N-containing mats. The mats’ cytotoxicity toward HeLa carcinoma cells and normal mouse BALB/c 3T3 fibroblasts was assessed. The 5N-in-CA, PVP,5N-on-(5N-in-CA) and PVA,5N-on-(5N-in-CA) fibrous mats possessed anticancer efficacies and much lower levels of toxicity against normal cells. Therefore, the as-created novel electrospun materials, which are based on polymers loaded with the drug 5N via electrospinning/electrospraying, can potentially be applied for topical wound healing and for local cancer therapy.
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spelling pubmed-102950472023-06-28 Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities Spasova, Mariya Stoyanova, Nikoleta Nachev, Nasko Ignatova, Milena Manolova, Nevena Rashkov, Iliya Georgieva, Ani Toshkova, Reneta Markova, Nadya Antioxidants (Basel) Article A new type of fibrous mat based on a cellulose derivative—cellulose acetate (CA) or CA and water-soluble polymers (polyvinylpyrrolidone, PVP or poly(vinyl alcohol), PVA)—loaded with the model drug 5-nitro-8-hydroxyquinoline (5N) was fabricated via electrospinning or electrospinning in conjunction with electrospraying. Scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FTIR), water contact angle measurements and ultraviolet-visible spectroscopy (UV-Vis) were used for the complex characterization of the obtained novel material. The decoration of CA fibers with a water-soluble polymer containing the drug resulted in the facilitation of wetting and fast drug release. The 5N-containing fibrous material showed antioxidant activity. Moreover, the proposed materials’ antibacterial and antifungal properties were tested against S. aureus, E. coli, P. aeruginosa and C. albicans. Well-distinguished, sterile zones with diameters above 3.5 cm were observed around all 5N-containing mats. The mats’ cytotoxicity toward HeLa carcinoma cells and normal mouse BALB/c 3T3 fibroblasts was assessed. The 5N-in-CA, PVP,5N-on-(5N-in-CA) and PVA,5N-on-(5N-in-CA) fibrous mats possessed anticancer efficacies and much lower levels of toxicity against normal cells. Therefore, the as-created novel electrospun materials, which are based on polymers loaded with the drug 5N via electrospinning/electrospraying, can potentially be applied for topical wound healing and for local cancer therapy. MDPI 2023-06-09 /pmc/articles/PMC10295047/ /pubmed/37371973 http://dx.doi.org/10.3390/antiox12061243 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spasova, Mariya
Stoyanova, Nikoleta
Nachev, Nasko
Ignatova, Milena
Manolova, Nevena
Rashkov, Iliya
Georgieva, Ani
Toshkova, Reneta
Markova, Nadya
Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities
title Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities
title_full Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities
title_fullStr Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities
title_full_unstemmed Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities
title_short Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities
title_sort innovative fibrous materials loaded with 5-nitro-8-hydroxyquinoline via electrospinning/electrospraying demonstrate antioxidant, antimicrobial and anticancer activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295047/
https://www.ncbi.nlm.nih.gov/pubmed/37371973
http://dx.doi.org/10.3390/antiox12061243
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