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Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review
Introduction: Antimicrobial resistance is a major healthcare issue responsible for a large number of deaths. Many reviews identified that PKPD data are in favor of the use of continuous infusion, and we wanted to review clinical data results in order to optimize our clinical practice. Methodology: W...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295077/ https://www.ncbi.nlm.nih.gov/pubmed/37370371 http://dx.doi.org/10.3390/antibiotics12061052 |
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author | Diamantis, Sylvain Chakvetadze, Catherine de Pontfarcy, Astrid Matta, Matta |
author_facet | Diamantis, Sylvain Chakvetadze, Catherine de Pontfarcy, Astrid Matta, Matta |
author_sort | Diamantis, Sylvain |
collection | PubMed |
description | Introduction: Antimicrobial resistance is a major healthcare issue responsible for a large number of deaths. Many reviews identified that PKPD data are in favor of the use of continuous infusion, and we wanted to review clinical data results in order to optimize our clinical practice. Methodology: We reviewed Medline for existing literature comparing continuous or extended infusion to intermittent infusion of betalactams. Results: In clinical studies, continuous infusion is as good as intermittent infusion. In the subset group of critically ill patients or those with an infection due to an organism with high MIC, a continuous infusion was associated with better clinical response. Conclusions: Clinical data appear to confirm those of PK/PD to use a continuous infusion in severely ill patients or those infected by an organism with an elevated MIC, as it is associated with higher survival rates. In other cases, it may allow for a decrease in antibiotic daily dosage, thereby contributing to a decrease in overall costs. |
format | Online Article Text |
id | pubmed-10295077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102950772023-06-28 Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review Diamantis, Sylvain Chakvetadze, Catherine de Pontfarcy, Astrid Matta, Matta Antibiotics (Basel) Review Introduction: Antimicrobial resistance is a major healthcare issue responsible for a large number of deaths. Many reviews identified that PKPD data are in favor of the use of continuous infusion, and we wanted to review clinical data results in order to optimize our clinical practice. Methodology: We reviewed Medline for existing literature comparing continuous or extended infusion to intermittent infusion of betalactams. Results: In clinical studies, continuous infusion is as good as intermittent infusion. In the subset group of critically ill patients or those with an infection due to an organism with high MIC, a continuous infusion was associated with better clinical response. Conclusions: Clinical data appear to confirm those of PK/PD to use a continuous infusion in severely ill patients or those infected by an organism with an elevated MIC, as it is associated with higher survival rates. In other cases, it may allow for a decrease in antibiotic daily dosage, thereby contributing to a decrease in overall costs. MDPI 2023-06-15 /pmc/articles/PMC10295077/ /pubmed/37370371 http://dx.doi.org/10.3390/antibiotics12061052 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Diamantis, Sylvain Chakvetadze, Catherine de Pontfarcy, Astrid Matta, Matta Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review |
title | Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review |
title_full | Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review |
title_fullStr | Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review |
title_full_unstemmed | Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review |
title_short | Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review |
title_sort | optimizing betalactam clinical response by using a continuous infusion: a comprehensive review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295077/ https://www.ncbi.nlm.nih.gov/pubmed/37370371 http://dx.doi.org/10.3390/antibiotics12061052 |
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