Cargando…

Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review

Introduction: Antimicrobial resistance is a major healthcare issue responsible for a large number of deaths. Many reviews identified that PKPD data are in favor of the use of continuous infusion, and we wanted to review clinical data results in order to optimize our clinical practice. Methodology: W...

Descripción completa

Detalles Bibliográficos
Autores principales: Diamantis, Sylvain, Chakvetadze, Catherine, de Pontfarcy, Astrid, Matta, Matta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295077/
https://www.ncbi.nlm.nih.gov/pubmed/37370371
http://dx.doi.org/10.3390/antibiotics12061052
_version_ 1785063334616236032
author Diamantis, Sylvain
Chakvetadze, Catherine
de Pontfarcy, Astrid
Matta, Matta
author_facet Diamantis, Sylvain
Chakvetadze, Catherine
de Pontfarcy, Astrid
Matta, Matta
author_sort Diamantis, Sylvain
collection PubMed
description Introduction: Antimicrobial resistance is a major healthcare issue responsible for a large number of deaths. Many reviews identified that PKPD data are in favor of the use of continuous infusion, and we wanted to review clinical data results in order to optimize our clinical practice. Methodology: We reviewed Medline for existing literature comparing continuous or extended infusion to intermittent infusion of betalactams. Results: In clinical studies, continuous infusion is as good as intermittent infusion. In the subset group of critically ill patients or those with an infection due to an organism with high MIC, a continuous infusion was associated with better clinical response. Conclusions: Clinical data appear to confirm those of PK/PD to use a continuous infusion in severely ill patients or those infected by an organism with an elevated MIC, as it is associated with higher survival rates. In other cases, it may allow for a decrease in antibiotic daily dosage, thereby contributing to a decrease in overall costs.
format Online
Article
Text
id pubmed-10295077
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102950772023-06-28 Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review Diamantis, Sylvain Chakvetadze, Catherine de Pontfarcy, Astrid Matta, Matta Antibiotics (Basel) Review Introduction: Antimicrobial resistance is a major healthcare issue responsible for a large number of deaths. Many reviews identified that PKPD data are in favor of the use of continuous infusion, and we wanted to review clinical data results in order to optimize our clinical practice. Methodology: We reviewed Medline for existing literature comparing continuous or extended infusion to intermittent infusion of betalactams. Results: In clinical studies, continuous infusion is as good as intermittent infusion. In the subset group of critically ill patients or those with an infection due to an organism with high MIC, a continuous infusion was associated with better clinical response. Conclusions: Clinical data appear to confirm those of PK/PD to use a continuous infusion in severely ill patients or those infected by an organism with an elevated MIC, as it is associated with higher survival rates. In other cases, it may allow for a decrease in antibiotic daily dosage, thereby contributing to a decrease in overall costs. MDPI 2023-06-15 /pmc/articles/PMC10295077/ /pubmed/37370371 http://dx.doi.org/10.3390/antibiotics12061052 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Diamantis, Sylvain
Chakvetadze, Catherine
de Pontfarcy, Astrid
Matta, Matta
Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review
title Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review
title_full Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review
title_fullStr Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review
title_full_unstemmed Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review
title_short Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review
title_sort optimizing betalactam clinical response by using a continuous infusion: a comprehensive review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295077/
https://www.ncbi.nlm.nih.gov/pubmed/37370371
http://dx.doi.org/10.3390/antibiotics12061052
work_keys_str_mv AT diamantissylvain optimizingbetalactamclinicalresponsebyusingacontinuousinfusionacomprehensivereview
AT chakvetadzecatherine optimizingbetalactamclinicalresponsebyusingacontinuousinfusionacomprehensivereview
AT depontfarcyastrid optimizingbetalactamclinicalresponsebyusingacontinuousinfusionacomprehensivereview
AT mattamatta optimizingbetalactamclinicalresponsebyusingacontinuousinfusionacomprehensivereview