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Oxidative Stress in a Mother Consuming Alcohol during Pregnancy and in Her Newborn: A Case Report

Fetal alcohol spectrum disorder (FASD) is a set of conditions resulting from prenatal alcohol exposure (PAE). FASD is estimated to affect between 2% and 5% of people in the United States and Western Europe. The exact teratogenic mechanism of alcohol on fetal development is still unclear. Ethanol (Et...

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Autores principales: Derme, Martina, Piccioni, Maria Grazia, Brunelli, Roberto, Crognale, Alba, Denotti, Marika, Ciolli, Paola, Scomparin, Debora, Tarani, Luigi, Paparella, Roberto, Terrin, Gianluca, Di Chiara, Maria, Mattia, Alessandro, Nicotera, Simona, Salomone, Alberto, Ceccanti, Mauro, Messina, Marisa Patrizia, Maida, Nunzia La, Ferraguti, Giampiero, Petrella, Carla, Fiore, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295254/
https://www.ncbi.nlm.nih.gov/pubmed/37371946
http://dx.doi.org/10.3390/antiox12061216
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author Derme, Martina
Piccioni, Maria Grazia
Brunelli, Roberto
Crognale, Alba
Denotti, Marika
Ciolli, Paola
Scomparin, Debora
Tarani, Luigi
Paparella, Roberto
Terrin, Gianluca
Di Chiara, Maria
Mattia, Alessandro
Nicotera, Simona
Salomone, Alberto
Ceccanti, Mauro
Messina, Marisa Patrizia
Maida, Nunzia La
Ferraguti, Giampiero
Petrella, Carla
Fiore, Marco
author_facet Derme, Martina
Piccioni, Maria Grazia
Brunelli, Roberto
Crognale, Alba
Denotti, Marika
Ciolli, Paola
Scomparin, Debora
Tarani, Luigi
Paparella, Roberto
Terrin, Gianluca
Di Chiara, Maria
Mattia, Alessandro
Nicotera, Simona
Salomone, Alberto
Ceccanti, Mauro
Messina, Marisa Patrizia
Maida, Nunzia La
Ferraguti, Giampiero
Petrella, Carla
Fiore, Marco
author_sort Derme, Martina
collection PubMed
description Fetal alcohol spectrum disorder (FASD) is a set of conditions resulting from prenatal alcohol exposure (PAE). FASD is estimated to affect between 2% and 5% of people in the United States and Western Europe. The exact teratogenic mechanism of alcohol on fetal development is still unclear. Ethanol (EtOH) contributes to the malfunctioning of the neurological system in children exposed in utero by decreasing glutathione peroxidase action, with an increase in the production of reactive oxygen species (ROS), which causes oxidative stress. We report a case of a mother with declared alcohol abuse and cigarette smoking during pregnancy. By analyzing the ethyl glucuronide (EtG, a metabolite of alcohol) and the nicotine/cotinine in the mother’s hair and meconium, we confirmed the alcohol and smoking abuse magnitude. We also found that the mother during pregnancy was a cocaine abuser. As a result, her newborn was diagnosed with fetal alcohol syndrome (FAS). At the time of the delivery, the mother, but not the newborn, had an elevation in oxidative stress. However, the infant, a few days later, displayed marked potentiation in oxidative stress. The clinical complexity of the events involving the infant was presented and discussed, underlining also the importance that for cases of FASD, it is crucial to have more intensive hospital monitoring and controls during the initial days.
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spelling pubmed-102952542023-06-28 Oxidative Stress in a Mother Consuming Alcohol during Pregnancy and in Her Newborn: A Case Report Derme, Martina Piccioni, Maria Grazia Brunelli, Roberto Crognale, Alba Denotti, Marika Ciolli, Paola Scomparin, Debora Tarani, Luigi Paparella, Roberto Terrin, Gianluca Di Chiara, Maria Mattia, Alessandro Nicotera, Simona Salomone, Alberto Ceccanti, Mauro Messina, Marisa Patrizia Maida, Nunzia La Ferraguti, Giampiero Petrella, Carla Fiore, Marco Antioxidants (Basel) Case Report Fetal alcohol spectrum disorder (FASD) is a set of conditions resulting from prenatal alcohol exposure (PAE). FASD is estimated to affect between 2% and 5% of people in the United States and Western Europe. The exact teratogenic mechanism of alcohol on fetal development is still unclear. Ethanol (EtOH) contributes to the malfunctioning of the neurological system in children exposed in utero by decreasing glutathione peroxidase action, with an increase in the production of reactive oxygen species (ROS), which causes oxidative stress. We report a case of a mother with declared alcohol abuse and cigarette smoking during pregnancy. By analyzing the ethyl glucuronide (EtG, a metabolite of alcohol) and the nicotine/cotinine in the mother’s hair and meconium, we confirmed the alcohol and smoking abuse magnitude. We also found that the mother during pregnancy was a cocaine abuser. As a result, her newborn was diagnosed with fetal alcohol syndrome (FAS). At the time of the delivery, the mother, but not the newborn, had an elevation in oxidative stress. However, the infant, a few days later, displayed marked potentiation in oxidative stress. The clinical complexity of the events involving the infant was presented and discussed, underlining also the importance that for cases of FASD, it is crucial to have more intensive hospital monitoring and controls during the initial days. MDPI 2023-06-04 /pmc/articles/PMC10295254/ /pubmed/37371946 http://dx.doi.org/10.3390/antiox12061216 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Derme, Martina
Piccioni, Maria Grazia
Brunelli, Roberto
Crognale, Alba
Denotti, Marika
Ciolli, Paola
Scomparin, Debora
Tarani, Luigi
Paparella, Roberto
Terrin, Gianluca
Di Chiara, Maria
Mattia, Alessandro
Nicotera, Simona
Salomone, Alberto
Ceccanti, Mauro
Messina, Marisa Patrizia
Maida, Nunzia La
Ferraguti, Giampiero
Petrella, Carla
Fiore, Marco
Oxidative Stress in a Mother Consuming Alcohol during Pregnancy and in Her Newborn: A Case Report
title Oxidative Stress in a Mother Consuming Alcohol during Pregnancy and in Her Newborn: A Case Report
title_full Oxidative Stress in a Mother Consuming Alcohol during Pregnancy and in Her Newborn: A Case Report
title_fullStr Oxidative Stress in a Mother Consuming Alcohol during Pregnancy and in Her Newborn: A Case Report
title_full_unstemmed Oxidative Stress in a Mother Consuming Alcohol during Pregnancy and in Her Newborn: A Case Report
title_short Oxidative Stress in a Mother Consuming Alcohol during Pregnancy and in Her Newborn: A Case Report
title_sort oxidative stress in a mother consuming alcohol during pregnancy and in her newborn: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295254/
https://www.ncbi.nlm.nih.gov/pubmed/37371946
http://dx.doi.org/10.3390/antiox12061216
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