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Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review
We review the research progress on noninvasive neural regulatory systems through system design and theoretical guidance. We provide an overview of the development history of noninvasive neuromodulation technology, focusing on system design. We also discuss typical cases of neuromodulation that use m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295338/ https://www.ncbi.nlm.nih.gov/pubmed/37371609 http://dx.doi.org/10.3390/biomedicines11061513 |
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author | Zhang, Shuang Qin, Yuping Wang, Jiujiang Yu, Yuanyu Wu, Lin Zhang, Tao |
author_facet | Zhang, Shuang Qin, Yuping Wang, Jiujiang Yu, Yuanyu Wu, Lin Zhang, Tao |
author_sort | Zhang, Shuang |
collection | PubMed |
description | We review the research progress on noninvasive neural regulatory systems through system design and theoretical guidance. We provide an overview of the development history of noninvasive neuromodulation technology, focusing on system design. We also discuss typical cases of neuromodulation that use modern noninvasive electrical stimulation and the main limitations associated with this technology. In addition, we propose a closed-loop system design solution of the “time domain”, “space domain”, and “multi-electrode combination”. For theoretical guidance, this paper provides an overview of the “digital brain” development process used for noninvasive electrical-stimulation-targeted modeling and the development of “digital human” programs in various countries. We also summarize the core problems of the existing “digital brain” used for noninvasive electrical-stimulation-targeted modeling according to the existing achievements and propose segmenting the tissue. For this, the tissue parameters of a multimodal image obtained from a fresh cadaver were considered as an index. The digital projection of the multimodal image of the brain of a living individual was implemented, following which the segmented tissues could be reconstructed to obtain a “digital twin brain” model with personalized tissue structure differences. The “closed-loop system” and “personalized digital twin brain” not only enable the noninvasive electrical stimulation of neuromodulation to achieve the visualization of the results and adaptive regulation of the stimulation parameters but also enable the system to have individual differences and more accurate stimulation. |
format | Online Article Text |
id | pubmed-10295338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102953382023-06-28 Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review Zhang, Shuang Qin, Yuping Wang, Jiujiang Yu, Yuanyu Wu, Lin Zhang, Tao Biomedicines Review We review the research progress on noninvasive neural regulatory systems through system design and theoretical guidance. We provide an overview of the development history of noninvasive neuromodulation technology, focusing on system design. We also discuss typical cases of neuromodulation that use modern noninvasive electrical stimulation and the main limitations associated with this technology. In addition, we propose a closed-loop system design solution of the “time domain”, “space domain”, and “multi-electrode combination”. For theoretical guidance, this paper provides an overview of the “digital brain” development process used for noninvasive electrical-stimulation-targeted modeling and the development of “digital human” programs in various countries. We also summarize the core problems of the existing “digital brain” used for noninvasive electrical-stimulation-targeted modeling according to the existing achievements and propose segmenting the tissue. For this, the tissue parameters of a multimodal image obtained from a fresh cadaver were considered as an index. The digital projection of the multimodal image of the brain of a living individual was implemented, following which the segmented tissues could be reconstructed to obtain a “digital twin brain” model with personalized tissue structure differences. The “closed-loop system” and “personalized digital twin brain” not only enable the noninvasive electrical stimulation of neuromodulation to achieve the visualization of the results and adaptive regulation of the stimulation parameters but also enable the system to have individual differences and more accurate stimulation. MDPI 2023-05-23 /pmc/articles/PMC10295338/ /pubmed/37371609 http://dx.doi.org/10.3390/biomedicines11061513 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Shuang Qin, Yuping Wang, Jiujiang Yu, Yuanyu Wu, Lin Zhang, Tao Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review |
title | Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review |
title_full | Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review |
title_fullStr | Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review |
title_full_unstemmed | Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review |
title_short | Noninvasive Electrical Stimulation Neuromodulation and Digital Brain Technology: A Review |
title_sort | noninvasive electrical stimulation neuromodulation and digital brain technology: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295338/ https://www.ncbi.nlm.nih.gov/pubmed/37371609 http://dx.doi.org/10.3390/biomedicines11061513 |
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