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Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges
Several insects are known as vectors of a wide range of animal and human pathogens causing various diseases. However, they are also a source of different substances, such as the Antimicrobial Peptides (AMPs), which can be employed in the development of natural bioactive compounds for medical, veteri...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295358/ https://www.ncbi.nlm.nih.gov/pubmed/37370271 http://dx.doi.org/10.3390/antibiotics12060952 |
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author | Dho, Matteo Candian, Valentina Tedeschi, Rosemarie |
author_facet | Dho, Matteo Candian, Valentina Tedeschi, Rosemarie |
author_sort | Dho, Matteo |
collection | PubMed |
description | Several insects are known as vectors of a wide range of animal and human pathogens causing various diseases. However, they are also a source of different substances, such as the Antimicrobial Peptides (AMPs), which can be employed in the development of natural bioactive compounds for medical, veterinary and agricultural applications. It is well known that AMP activity, in contrast to most classical antibiotics, does not lead to the development of natural bacterial resistance, or at least the frequency of resistance is considered to be low. Therefore, there is a strong interest in assessing the efficacy of the various peptides known to date, identifying new compounds and evaluating possible solutions in order to increase their production. Moreover, implementing AMP modulation in insect rearing could preserve insect health in large-scale production. This review describes the current knowledge on insect AMPs, presenting the validated ones for the different insect orders. A brief description of their mechanism of action is reported with focus on proposed applications. The possible effects of insect diet on AMP translation and synthesis have been discussed. |
format | Online Article Text |
id | pubmed-10295358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102953582023-06-28 Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges Dho, Matteo Candian, Valentina Tedeschi, Rosemarie Antibiotics (Basel) Review Several insects are known as vectors of a wide range of animal and human pathogens causing various diseases. However, they are also a source of different substances, such as the Antimicrobial Peptides (AMPs), which can be employed in the development of natural bioactive compounds for medical, veterinary and agricultural applications. It is well known that AMP activity, in contrast to most classical antibiotics, does not lead to the development of natural bacterial resistance, or at least the frequency of resistance is considered to be low. Therefore, there is a strong interest in assessing the efficacy of the various peptides known to date, identifying new compounds and evaluating possible solutions in order to increase their production. Moreover, implementing AMP modulation in insect rearing could preserve insect health in large-scale production. This review describes the current knowledge on insect AMPs, presenting the validated ones for the different insect orders. A brief description of their mechanism of action is reported with focus on proposed applications. The possible effects of insect diet on AMP translation and synthesis have been discussed. MDPI 2023-05-24 /pmc/articles/PMC10295358/ /pubmed/37370271 http://dx.doi.org/10.3390/antibiotics12060952 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dho, Matteo Candian, Valentina Tedeschi, Rosemarie Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges |
title | Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges |
title_full | Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges |
title_fullStr | Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges |
title_full_unstemmed | Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges |
title_short | Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges |
title_sort | insect antimicrobial peptides: advancements, enhancements and new challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295358/ https://www.ncbi.nlm.nih.gov/pubmed/37370271 http://dx.doi.org/10.3390/antibiotics12060952 |
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