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Controlled Attenuation Parameter Is Associated with a Distinct Systemic Inflammatory Milieu after Clearance of HCV Infection

Hepatitis C virus (HCV) infection is closely associated with lipid metabolism defects along with a high prevalence of hepatic steatosis. After HCV clearance, steatosis persists in many patients. However, the reasons behind this phenomenon are not completely clear. To investigate the association betw...

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Autores principales: Du, Yanqin, Khera, Tanvi, Liu, Zhaoli, Tudrujek-Zdunek, Magdalena, Dworzanska, Anna, Cornberg, Markus, Xu, Cheng-Jian, Tomasiewicz, Krzysztof, Wedemeyer, Heiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295384/
https://www.ncbi.nlm.nih.gov/pubmed/37371624
http://dx.doi.org/10.3390/biomedicines11061529
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author Du, Yanqin
Khera, Tanvi
Liu, Zhaoli
Tudrujek-Zdunek, Magdalena
Dworzanska, Anna
Cornberg, Markus
Xu, Cheng-Jian
Tomasiewicz, Krzysztof
Wedemeyer, Heiner
author_facet Du, Yanqin
Khera, Tanvi
Liu, Zhaoli
Tudrujek-Zdunek, Magdalena
Dworzanska, Anna
Cornberg, Markus
Xu, Cheng-Jian
Tomasiewicz, Krzysztof
Wedemeyer, Heiner
author_sort Du, Yanqin
collection PubMed
description Hepatitis C virus (HCV) infection is closely associated with lipid metabolism defects along with a high prevalence of hepatic steatosis. After HCV clearance, steatosis persists in many patients. However, the reasons behind this phenomenon are not completely clear. To investigate the association between 92 soluble inflammatory mediators (SIMs) and the steatosis grade, we made use of a cohort of 94 patients with chronic HCV infection who cleared HCV after direct-acting antiviral agent (DAA) treatment. Patients were classified into three groups according to their controlled attenuation parameter (CAP). CAP is associated with ALT, γ-GT and liver stiffness after HCV clearance. While stem cell factor (SCF) and tumor necrosis factor ligand superfamily member 12 (TWEAK) levels were significantly reduced in patients with CAP > 299 dB/m, the levels of fibroblast growth factor (FGF)-21 and interleukin-18 receptor 1 (IL-18R1) were higher in those patients at week 96 after virus clearance. These four markers also showed a linear correlation with CAP values. FGF-21 levels correlated with CAP only after HCV clearance. Taken together, these four biomarkers, namely SCF, TWEAK, FGF-21 and IL-18R1, are associated with CAP status after virus clearance. A potential role of these proteins in the pathogenesis of post-sustained viral response (SVR) nonalcoholic steatohepatitis requires further investigation.
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spelling pubmed-102953842023-06-28 Controlled Attenuation Parameter Is Associated with a Distinct Systemic Inflammatory Milieu after Clearance of HCV Infection Du, Yanqin Khera, Tanvi Liu, Zhaoli Tudrujek-Zdunek, Magdalena Dworzanska, Anna Cornberg, Markus Xu, Cheng-Jian Tomasiewicz, Krzysztof Wedemeyer, Heiner Biomedicines Article Hepatitis C virus (HCV) infection is closely associated with lipid metabolism defects along with a high prevalence of hepatic steatosis. After HCV clearance, steatosis persists in many patients. However, the reasons behind this phenomenon are not completely clear. To investigate the association between 92 soluble inflammatory mediators (SIMs) and the steatosis grade, we made use of a cohort of 94 patients with chronic HCV infection who cleared HCV after direct-acting antiviral agent (DAA) treatment. Patients were classified into three groups according to their controlled attenuation parameter (CAP). CAP is associated with ALT, γ-GT and liver stiffness after HCV clearance. While stem cell factor (SCF) and tumor necrosis factor ligand superfamily member 12 (TWEAK) levels were significantly reduced in patients with CAP > 299 dB/m, the levels of fibroblast growth factor (FGF)-21 and interleukin-18 receptor 1 (IL-18R1) were higher in those patients at week 96 after virus clearance. These four markers also showed a linear correlation with CAP values. FGF-21 levels correlated with CAP only after HCV clearance. Taken together, these four biomarkers, namely SCF, TWEAK, FGF-21 and IL-18R1, are associated with CAP status after virus clearance. A potential role of these proteins in the pathogenesis of post-sustained viral response (SVR) nonalcoholic steatohepatitis requires further investigation. MDPI 2023-05-25 /pmc/articles/PMC10295384/ /pubmed/37371624 http://dx.doi.org/10.3390/biomedicines11061529 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Du, Yanqin
Khera, Tanvi
Liu, Zhaoli
Tudrujek-Zdunek, Magdalena
Dworzanska, Anna
Cornberg, Markus
Xu, Cheng-Jian
Tomasiewicz, Krzysztof
Wedemeyer, Heiner
Controlled Attenuation Parameter Is Associated with a Distinct Systemic Inflammatory Milieu after Clearance of HCV Infection
title Controlled Attenuation Parameter Is Associated with a Distinct Systemic Inflammatory Milieu after Clearance of HCV Infection
title_full Controlled Attenuation Parameter Is Associated with a Distinct Systemic Inflammatory Milieu after Clearance of HCV Infection
title_fullStr Controlled Attenuation Parameter Is Associated with a Distinct Systemic Inflammatory Milieu after Clearance of HCV Infection
title_full_unstemmed Controlled Attenuation Parameter Is Associated with a Distinct Systemic Inflammatory Milieu after Clearance of HCV Infection
title_short Controlled Attenuation Parameter Is Associated with a Distinct Systemic Inflammatory Milieu after Clearance of HCV Infection
title_sort controlled attenuation parameter is associated with a distinct systemic inflammatory milieu after clearance of hcv infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295384/
https://www.ncbi.nlm.nih.gov/pubmed/37371624
http://dx.doi.org/10.3390/biomedicines11061529
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