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Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series

SIMPLE SUMMARY: Thawed plasma (TP) refers to defrosted fresh frozen plasma stored refrigerated. TP is used in human medicine for the rapid provision of clotting factors for the treatment of life-threatening bleeding but its use in dogs has been poorly described. The objectives of this historical cas...

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Autores principales: Chee, Weiqin, Sharp, Claire R., Boyd, Corrin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295404/
https://www.ncbi.nlm.nih.gov/pubmed/37370550
http://dx.doi.org/10.3390/ani13122040
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author Chee, Weiqin
Sharp, Claire R.
Boyd, Corrin J.
author_facet Chee, Weiqin
Sharp, Claire R.
Boyd, Corrin J.
author_sort Chee, Weiqin
collection PubMed
description SIMPLE SUMMARY: Thawed plasma (TP) refers to defrosted fresh frozen plasma stored refrigerated. TP is used in human medicine for the rapid provision of clotting factors for the treatment of life-threatening bleeding but its use in dogs has been poorly described. The objectives of this historical case series were to describe the reasons for TP transfusion, treatment outcomes, and adverse events associated with canine TP transfusions in a veterinary teaching hospital. We hypothesised that TP would be used most commonly for the treatment of haemorrhage secondary to anticoagulant rodenticide intoxication and trauma. Blood bank plasma transfusion logs were searched to identify dogs that received at least one unit of TP. Briefly, 166 dogs received a total of 262 units of TP. Anticoagulant rodenticide intoxication (37/166, 22.3%) was the most common reason for transfusion, followed by traumatic haemorrhage (23, 13.9%) and spontaneous haemoperitoneum (22, 13.2%). The majority of dogs received one unit of TP (111/166, 67.1%) and packed red blood cells (pRBCs) were commonly simultaneously transfused with TP (65, 39.2%). Severe prolongations of clotting times were reduced following TP transfusions. Allergic reactions were the most common transfusion reaction (19/166, 11.4%). Most dogs survived to discharge (101/166, 60.8%). ABSTRACT: Thawed plasma (TP) refers to defrosted fresh frozen plasma stored refrigerated. TP is used in human medicine for the rapid provision of coagulation factors and resuscitation of haemorrhagic shock, but its use in dogs is poorly described. The objectives of this historical case series were to describe the reasons for TP transfusion, treatment outcomes, and adverse events associated with canine TP transfusions in a veterinary teaching hospital. We hypothesised that TP would be used most commonly for the treatment of haemorrhage secondary to anticoagulant rodenticide intoxication and trauma. Blood bank plasma transfusion logs were searched to identify dogs that received at least one unit of TP between December 2015 and June 2021. Briefly, 166 dogs received a total of 262 units of TP. Anticoagulant rodenticide intoxication (37/166, 22.3%) was the most common reason for transfusion, followed by traumatic haemorrhage (23, 13.9%) and spontaneous haemoperitoneum (22, 13.2%). The majority of dogs received one unit of TP (111/166, 67.1%) and pRBCs were commonly simultaneously transfused with TP (65, 39.2%). Severe prolongations of prothrombin time and activated partial thromboplastin time were reduced following TP transfusions. Allergic reactions were the most common transfusion reaction (19/166, 11.4%). Most dogs survived to discharge (101/166, 60.8%).
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spelling pubmed-102954042023-06-28 Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series Chee, Weiqin Sharp, Claire R. Boyd, Corrin J. Animals (Basel) Article SIMPLE SUMMARY: Thawed plasma (TP) refers to defrosted fresh frozen plasma stored refrigerated. TP is used in human medicine for the rapid provision of clotting factors for the treatment of life-threatening bleeding but its use in dogs has been poorly described. The objectives of this historical case series were to describe the reasons for TP transfusion, treatment outcomes, and adverse events associated with canine TP transfusions in a veterinary teaching hospital. We hypothesised that TP would be used most commonly for the treatment of haemorrhage secondary to anticoagulant rodenticide intoxication and trauma. Blood bank plasma transfusion logs were searched to identify dogs that received at least one unit of TP. Briefly, 166 dogs received a total of 262 units of TP. Anticoagulant rodenticide intoxication (37/166, 22.3%) was the most common reason for transfusion, followed by traumatic haemorrhage (23, 13.9%) and spontaneous haemoperitoneum (22, 13.2%). The majority of dogs received one unit of TP (111/166, 67.1%) and packed red blood cells (pRBCs) were commonly simultaneously transfused with TP (65, 39.2%). Severe prolongations of clotting times were reduced following TP transfusions. Allergic reactions were the most common transfusion reaction (19/166, 11.4%). Most dogs survived to discharge (101/166, 60.8%). ABSTRACT: Thawed plasma (TP) refers to defrosted fresh frozen plasma stored refrigerated. TP is used in human medicine for the rapid provision of coagulation factors and resuscitation of haemorrhagic shock, but its use in dogs is poorly described. The objectives of this historical case series were to describe the reasons for TP transfusion, treatment outcomes, and adverse events associated with canine TP transfusions in a veterinary teaching hospital. We hypothesised that TP would be used most commonly for the treatment of haemorrhage secondary to anticoagulant rodenticide intoxication and trauma. Blood bank plasma transfusion logs were searched to identify dogs that received at least one unit of TP between December 2015 and June 2021. Briefly, 166 dogs received a total of 262 units of TP. Anticoagulant rodenticide intoxication (37/166, 22.3%) was the most common reason for transfusion, followed by traumatic haemorrhage (23, 13.9%) and spontaneous haemoperitoneum (22, 13.2%). The majority of dogs received one unit of TP (111/166, 67.1%) and pRBCs were commonly simultaneously transfused with TP (65, 39.2%). Severe prolongations of prothrombin time and activated partial thromboplastin time were reduced following TP transfusions. Allergic reactions were the most common transfusion reaction (19/166, 11.4%). Most dogs survived to discharge (101/166, 60.8%). MDPI 2023-06-20 /pmc/articles/PMC10295404/ /pubmed/37370550 http://dx.doi.org/10.3390/ani13122040 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chee, Weiqin
Sharp, Claire R.
Boyd, Corrin J.
Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series
title Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series
title_full Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series
title_fullStr Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series
title_full_unstemmed Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series
title_short Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series
title_sort clinical use of canine thawed refrigerated plasma: a historical case series
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295404/
https://www.ncbi.nlm.nih.gov/pubmed/37370550
http://dx.doi.org/10.3390/ani13122040
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