Cargando…
Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases
A common denominator of metabolic diseases, including type 2 diabetes Mellitus, dyslipidemia, and atherosclerosis, are elevated oxidative stress and chronic inflammation. These complex, multi-factorial diseases are caused by the detrimental interaction between the individual genetic background and m...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295442/ https://www.ncbi.nlm.nih.gov/pubmed/37372020 http://dx.doi.org/10.3390/antiox12061290 |
_version_ | 1785063421766533120 |
---|---|
author | Duisenbek, Ayauly Lopez-Armas, Gabriela C. Pérez, Miguel Avilés Pérez, María D. Aguilar Benitez, José Miguel Pereira Pérez, Víctor Roger Gorts Ortega, Juan Yessenbekova, Arailym Ablaikhanova, Nurzhanyat Escames, Germaine Acuña-Castroviejo, Darío Rusanova, Iryna |
author_facet | Duisenbek, Ayauly Lopez-Armas, Gabriela C. Pérez, Miguel Avilés Pérez, María D. Aguilar Benitez, José Miguel Pereira Pérez, Víctor Roger Gorts Ortega, Juan Yessenbekova, Arailym Ablaikhanova, Nurzhanyat Escames, Germaine Acuña-Castroviejo, Darío Rusanova, Iryna |
author_sort | Duisenbek, Ayauly |
collection | PubMed |
description | A common denominator of metabolic diseases, including type 2 diabetes Mellitus, dyslipidemia, and atherosclerosis, are elevated oxidative stress and chronic inflammation. These complex, multi-factorial diseases are caused by the detrimental interaction between the individual genetic background and multiple environmental stimuli. The cells, including the endothelial ones, acquire a preactivated phenotype and metabolic memory, exhibiting increased oxidative stress, inflammatory gene expression, endothelial vascular activation, and prothrombotic events, leading to vascular complications. There are different pathways involved in the pathogenesis of metabolic diseases, and increased knowledge suggests a role of the activation of the NF-kB pathway and NLRP3 inflammasome as key mediators of metabolic inflammation. Epigenetic-wide associated studies provide new insight into the role of microRNAs in the phenomenon of metabolic memory and the development consequences of vessel damage. In this review, we will focus on the microRNAs related to the control of anti-oxidative enzymes, as well as microRNAs related to the control of mitochondrial functions and inflammation. The objective is the search for new therapeutic targets to improve the functioning of mitochondria and reduce oxidative stress and inflammation, despite the acquired metabolic memory. |
format | Online Article Text |
id | pubmed-10295442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102954422023-06-28 Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases Duisenbek, Ayauly Lopez-Armas, Gabriela C. Pérez, Miguel Avilés Pérez, María D. Aguilar Benitez, José Miguel Pereira Pérez, Víctor Roger Gorts Ortega, Juan Yessenbekova, Arailym Ablaikhanova, Nurzhanyat Escames, Germaine Acuña-Castroviejo, Darío Rusanova, Iryna Antioxidants (Basel) Review A common denominator of metabolic diseases, including type 2 diabetes Mellitus, dyslipidemia, and atherosclerosis, are elevated oxidative stress and chronic inflammation. These complex, multi-factorial diseases are caused by the detrimental interaction between the individual genetic background and multiple environmental stimuli. The cells, including the endothelial ones, acquire a preactivated phenotype and metabolic memory, exhibiting increased oxidative stress, inflammatory gene expression, endothelial vascular activation, and prothrombotic events, leading to vascular complications. There are different pathways involved in the pathogenesis of metabolic diseases, and increased knowledge suggests a role of the activation of the NF-kB pathway and NLRP3 inflammasome as key mediators of metabolic inflammation. Epigenetic-wide associated studies provide new insight into the role of microRNAs in the phenomenon of metabolic memory and the development consequences of vessel damage. In this review, we will focus on the microRNAs related to the control of anti-oxidative enzymes, as well as microRNAs related to the control of mitochondrial functions and inflammation. The objective is the search for new therapeutic targets to improve the functioning of mitochondria and reduce oxidative stress and inflammation, despite the acquired metabolic memory. MDPI 2023-06-16 /pmc/articles/PMC10295442/ /pubmed/37372020 http://dx.doi.org/10.3390/antiox12061290 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Duisenbek, Ayauly Lopez-Armas, Gabriela C. Pérez, Miguel Avilés Pérez, María D. Aguilar Benitez, José Miguel Pereira Pérez, Víctor Roger Gorts Ortega, Juan Yessenbekova, Arailym Ablaikhanova, Nurzhanyat Escames, Germaine Acuña-Castroviejo, Darío Rusanova, Iryna Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases |
title | Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases |
title_full | Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases |
title_fullStr | Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases |
title_full_unstemmed | Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases |
title_short | Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases |
title_sort | insights into the role of plasmatic and exosomal micrornas in oxidative stress-related metabolic diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295442/ https://www.ncbi.nlm.nih.gov/pubmed/37372020 http://dx.doi.org/10.3390/antiox12061290 |
work_keys_str_mv | AT duisenbekayauly insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT lopezarmasgabrielac insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT perezmiguel insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT avilesperezmariad insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT aguilarbenitezjosemiguel insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT pereiraperezvictorroger insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT gortsortegajuan insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT yessenbekovaarailym insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT ablaikhanovanurzhanyat insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT escamesgermaine insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT acunacastroviejodario insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases AT rusanovairyna insightsintotheroleofplasmaticandexosomalmicrornasinoxidativestressrelatedmetabolicdiseases |