Exogenous 8-Hydroxydeoxyguanosine Attenuates PM(2.5)-Induced Inflammation in Human Bronchial Epithelial Cells by Decreasing NLRP3 Inflammasome Activation

Particulate matter 2.5 (PM(2.5)) induces lung injury by increasing the generation of reactive oxygen species (ROS) and inflammation. ROS aggravates NLRP3 inflammasome activation, which activates caspase-1, IL-1β, and IL-18 and induces pyroptosis; these factors propagate inflammation. In contrast, tr...

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Detalles Bibliográficos
Autores principales: Bang, Jihye, Son, Kuk Hui, Heo, Hye-Ryeon, Park, Eunsook, Kwak, Hyun-Jeong, Uhm, Kyung-Ok, Chung, Myung-Hee, Kim, Young-Youl, Lim, Hyun Joung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295443/
https://www.ncbi.nlm.nih.gov/pubmed/37371919
http://dx.doi.org/10.3390/antiox12061189

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