Cargando…
The Role of the Microbiome in the Pathogenesis and Treatment of Asthma
The role of the microbiome in the pathogenesis and treatment of asthma is significant. The purpose of this article is to show the interplay between asthma and the microbiome, and main areas that require further research are also highlighted. The literature search was conducted using the PubMed datab...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295573/ https://www.ncbi.nlm.nih.gov/pubmed/37371713 http://dx.doi.org/10.3390/biomedicines11061618 |
_version_ | 1785063453353836544 |
---|---|
author | Logoń, Katarzyna Świrkosz, Gabriela Nowak, Monika Wrześniewska, Martyna Szczygieł, Aleksandra Gomułka, Krzysztof |
author_facet | Logoń, Katarzyna Świrkosz, Gabriela Nowak, Monika Wrześniewska, Martyna Szczygieł, Aleksandra Gomułka, Krzysztof |
author_sort | Logoń, Katarzyna |
collection | PubMed |
description | The role of the microbiome in the pathogenesis and treatment of asthma is significant. The purpose of this article is to show the interplay between asthma and the microbiome, and main areas that require further research are also highlighted. The literature search was conducted using the PubMed database. After a screening process of studies published before May 2023, a total of 128 articles were selected in our paper. The pre-treatment bronchial microbiome in asthmatic patients plays a role in their responsiveness to treatment. Gut microbiota and its dysbiosis can contribute to immune system modulation and the development of asthma. The association between the microbiome and asthma is complex. Further research is necessary to clarify which factors might moderate that relationship. An appropriate gut microbiome and its intestinal metabolites are a protective factor for asthma development. Prebiotics and certain dietary strategies may have a prophylactic or therapeutic effect, but more research is needed to establish final conclusions. Although the evidence regarding probiotics is ambiguous, and most meta-analyses do not support the use of probiotic intake to reduce asthma, several of the most recent studies have provided promising effects. Further studies should focus on the investigation of specific strains and the examination of their mechanistic and genetic aspects. |
format | Online Article Text |
id | pubmed-10295573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102955732023-06-28 The Role of the Microbiome in the Pathogenesis and Treatment of Asthma Logoń, Katarzyna Świrkosz, Gabriela Nowak, Monika Wrześniewska, Martyna Szczygieł, Aleksandra Gomułka, Krzysztof Biomedicines Review The role of the microbiome in the pathogenesis and treatment of asthma is significant. The purpose of this article is to show the interplay between asthma and the microbiome, and main areas that require further research are also highlighted. The literature search was conducted using the PubMed database. After a screening process of studies published before May 2023, a total of 128 articles were selected in our paper. The pre-treatment bronchial microbiome in asthmatic patients plays a role in their responsiveness to treatment. Gut microbiota and its dysbiosis can contribute to immune system modulation and the development of asthma. The association between the microbiome and asthma is complex. Further research is necessary to clarify which factors might moderate that relationship. An appropriate gut microbiome and its intestinal metabolites are a protective factor for asthma development. Prebiotics and certain dietary strategies may have a prophylactic or therapeutic effect, but more research is needed to establish final conclusions. Although the evidence regarding probiotics is ambiguous, and most meta-analyses do not support the use of probiotic intake to reduce asthma, several of the most recent studies have provided promising effects. Further studies should focus on the investigation of specific strains and the examination of their mechanistic and genetic aspects. MDPI 2023-06-02 /pmc/articles/PMC10295573/ /pubmed/37371713 http://dx.doi.org/10.3390/biomedicines11061618 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Logoń, Katarzyna Świrkosz, Gabriela Nowak, Monika Wrześniewska, Martyna Szczygieł, Aleksandra Gomułka, Krzysztof The Role of the Microbiome in the Pathogenesis and Treatment of Asthma |
title | The Role of the Microbiome in the Pathogenesis and Treatment of Asthma |
title_full | The Role of the Microbiome in the Pathogenesis and Treatment of Asthma |
title_fullStr | The Role of the Microbiome in the Pathogenesis and Treatment of Asthma |
title_full_unstemmed | The Role of the Microbiome in the Pathogenesis and Treatment of Asthma |
title_short | The Role of the Microbiome in the Pathogenesis and Treatment of Asthma |
title_sort | role of the microbiome in the pathogenesis and treatment of asthma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295573/ https://www.ncbi.nlm.nih.gov/pubmed/37371713 http://dx.doi.org/10.3390/biomedicines11061618 |
work_keys_str_mv | AT logonkatarzyna theroleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT swirkoszgabriela theroleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT nowakmonika theroleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT wrzesniewskamartyna theroleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT szczygiełaleksandra theroleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT gomułkakrzysztof theroleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT logonkatarzyna roleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT swirkoszgabriela roleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT nowakmonika roleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT wrzesniewskamartyna roleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT szczygiełaleksandra roleofthemicrobiomeinthepathogenesisandtreatmentofasthma AT gomułkakrzysztof roleofthemicrobiomeinthepathogenesisandtreatmentofasthma |