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Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

Chronic, multifactorial illnesses of the gastrointestinal tract include inflammatory bowel diseases. One of the greatest methods for regulated medicine administration in a particular region of inflammation is the nanoparticle system. Silver nanoparticles (Ag NPs) have been utilized as drug delivery...

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Autores principales: Todorova, Mina, Milusheva, Miglena, Kaynarova, Lidia, Georgieva, Deyana, Delchev, Vassil, Simeonova, Stanislava, Pilicheva, Bissera, Nikolova, Stoyanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295628/
https://www.ncbi.nlm.nih.gov/pubmed/37371688
http://dx.doi.org/10.3390/biomedicines11061593
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author Todorova, Mina
Milusheva, Miglena
Kaynarova, Lidia
Georgieva, Deyana
Delchev, Vassil
Simeonova, Stanislava
Pilicheva, Bissera
Nikolova, Stoyanka
author_facet Todorova, Mina
Milusheva, Miglena
Kaynarova, Lidia
Georgieva, Deyana
Delchev, Vassil
Simeonova, Stanislava
Pilicheva, Bissera
Nikolova, Stoyanka
author_sort Todorova, Mina
collection PubMed
description Chronic, multifactorial illnesses of the gastrointestinal tract include inflammatory bowel diseases. One of the greatest methods for regulated medicine administration in a particular region of inflammation is the nanoparticle system. Silver nanoparticles (Ag NPs) have been utilized as drug delivery systems in the pharmaceutical industry. The goal of the current study is to synthesize drug-loaded Ag NPs using a previously described 3-methyl-1-phenylbutan-2-amine, as a mebeverine precursor (MP). Methods: A green, galactose-assisted method for the rapid synthesis and stabilization of Ag NPs as a drug-delivery system is presented. Galactose was used as a reducing and capping agent forming a thin layer encasing the nanoparticles. Results: The structure, size distribution, zeta potential, surface charge, and the role of the capping agent of drug-loaded Ag NPs were discussed. The drug release of the MP-loaded Ag NPs was also investigated. The Ag NPs indicated a very good drug release between 80 and 85%. Based on the preliminary results, Ag NPs might be a promising medication delivery system for MP and a useful treatment option for inflammatory bowel disease. Therefore, future research into the potential medical applications of the produced Ag NPs is necessary.
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spelling pubmed-102956282023-06-28 Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment Todorova, Mina Milusheva, Miglena Kaynarova, Lidia Georgieva, Deyana Delchev, Vassil Simeonova, Stanislava Pilicheva, Bissera Nikolova, Stoyanka Biomedicines Article Chronic, multifactorial illnesses of the gastrointestinal tract include inflammatory bowel diseases. One of the greatest methods for regulated medicine administration in a particular region of inflammation is the nanoparticle system. Silver nanoparticles (Ag NPs) have been utilized as drug delivery systems in the pharmaceutical industry. The goal of the current study is to synthesize drug-loaded Ag NPs using a previously described 3-methyl-1-phenylbutan-2-amine, as a mebeverine precursor (MP). Methods: A green, galactose-assisted method for the rapid synthesis and stabilization of Ag NPs as a drug-delivery system is presented. Galactose was used as a reducing and capping agent forming a thin layer encasing the nanoparticles. Results: The structure, size distribution, zeta potential, surface charge, and the role of the capping agent of drug-loaded Ag NPs were discussed. The drug release of the MP-loaded Ag NPs was also investigated. The Ag NPs indicated a very good drug release between 80 and 85%. Based on the preliminary results, Ag NPs might be a promising medication delivery system for MP and a useful treatment option for inflammatory bowel disease. Therefore, future research into the potential medical applications of the produced Ag NPs is necessary. MDPI 2023-05-30 /pmc/articles/PMC10295628/ /pubmed/37371688 http://dx.doi.org/10.3390/biomedicines11061593 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Todorova, Mina
Milusheva, Miglena
Kaynarova, Lidia
Georgieva, Deyana
Delchev, Vassil
Simeonova, Stanislava
Pilicheva, Bissera
Nikolova, Stoyanka
Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment
title Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment
title_full Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment
title_fullStr Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment
title_full_unstemmed Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment
title_short Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment
title_sort drug-loaded silver nanoparticles—a tool for delivery of a mebeverine precursor in inflammatory bowel diseases treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295628/
https://www.ncbi.nlm.nih.gov/pubmed/37371688
http://dx.doi.org/10.3390/biomedicines11061593
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