Cargando…
Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia
Schizophrenia patients with an earlier age of onset have been found to have more serious negative symptoms and cognitive deficits. Oxidative stress is thought to be implicated in cognitive impairment in schizophrenia. Total antioxidant capacity (TAOC) is an essential indicator of oxidative stress. H...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295646/ https://www.ncbi.nlm.nih.gov/pubmed/37371989 http://dx.doi.org/10.3390/antiox12061259 |
_version_ | 1785063470975156224 |
---|---|
author | Li, Jiaxin Li, Deyang Guo, Junru Wang, Dongmei Zhang, Xiangyang |
author_facet | Li, Jiaxin Li, Deyang Guo, Junru Wang, Dongmei Zhang, Xiangyang |
author_sort | Li, Jiaxin |
collection | PubMed |
description | Schizophrenia patients with an earlier age of onset have been found to have more serious negative symptoms and cognitive deficits. Oxidative stress is thought to be implicated in cognitive impairment in schizophrenia. Total antioxidant capacity (TAOC) is an essential indicator of oxidative stress. However, the association between age of onset, TAOC, and cognitive performance in schizophrenia remains unexplored. In this study, 201 patients (age: 26.5 ± 9.6 years; male: 53.2%) with drug-naïve schizophrenia were recruited. Clinical symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). Cognitive functioning was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Plasma TAOC levels were analyzed using established procedures. Results showed that early-onset (EO) patients had higher TAOC levels, more severe negative symptoms and performed worse on visuospatial/constructional, language and RBANS total scores than non-EO patients. After Bonferroni correction, only non-EO patients showed a significant inverse relationship between TAOC levels and RBANS language, attention, and total scores. Our findings suggest that an early/late age of onset may be correlated with psychopathological symptoms, cognitive impairment and oxidative responses in schizophrenia. Furthermore, the age of onset may moderate the relationship between TAOC and cognitive function in patients with schizophrenia. These findings suggest that improving oxidative stress status in non-EO schizophrenia patients may enhance their cognitive function. |
format | Online Article Text |
id | pubmed-10295646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102956462023-06-28 Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia Li, Jiaxin Li, Deyang Guo, Junru Wang, Dongmei Zhang, Xiangyang Antioxidants (Basel) Article Schizophrenia patients with an earlier age of onset have been found to have more serious negative symptoms and cognitive deficits. Oxidative stress is thought to be implicated in cognitive impairment in schizophrenia. Total antioxidant capacity (TAOC) is an essential indicator of oxidative stress. However, the association between age of onset, TAOC, and cognitive performance in schizophrenia remains unexplored. In this study, 201 patients (age: 26.5 ± 9.6 years; male: 53.2%) with drug-naïve schizophrenia were recruited. Clinical symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). Cognitive functioning was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Plasma TAOC levels were analyzed using established procedures. Results showed that early-onset (EO) patients had higher TAOC levels, more severe negative symptoms and performed worse on visuospatial/constructional, language and RBANS total scores than non-EO patients. After Bonferroni correction, only non-EO patients showed a significant inverse relationship between TAOC levels and RBANS language, attention, and total scores. Our findings suggest that an early/late age of onset may be correlated with psychopathological symptoms, cognitive impairment and oxidative responses in schizophrenia. Furthermore, the age of onset may moderate the relationship between TAOC and cognitive function in patients with schizophrenia. These findings suggest that improving oxidative stress status in non-EO schizophrenia patients may enhance their cognitive function. MDPI 2023-06-12 /pmc/articles/PMC10295646/ /pubmed/37371989 http://dx.doi.org/10.3390/antiox12061259 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Jiaxin Li, Deyang Guo, Junru Wang, Dongmei Zhang, Xiangyang Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia |
title | Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia |
title_full | Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia |
title_fullStr | Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia |
title_full_unstemmed | Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia |
title_short | Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia |
title_sort | age of onset moderates the association between total antioxidant capacity and cognitive deficits in patients with drug-naïve schizophrenia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295646/ https://www.ncbi.nlm.nih.gov/pubmed/37371989 http://dx.doi.org/10.3390/antiox12061259 |
work_keys_str_mv | AT lijiaxin ageofonsetmoderatestheassociationbetweentotalantioxidantcapacityandcognitivedeficitsinpatientswithdrugnaiveschizophrenia AT lideyang ageofonsetmoderatestheassociationbetweentotalantioxidantcapacityandcognitivedeficitsinpatientswithdrugnaiveschizophrenia AT guojunru ageofonsetmoderatestheassociationbetweentotalantioxidantcapacityandcognitivedeficitsinpatientswithdrugnaiveschizophrenia AT wangdongmei ageofonsetmoderatestheassociationbetweentotalantioxidantcapacityandcognitivedeficitsinpatientswithdrugnaiveschizophrenia AT zhangxiangyang ageofonsetmoderatestheassociationbetweentotalantioxidantcapacityandcognitivedeficitsinpatientswithdrugnaiveschizophrenia |