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Modeling and Validation of an Ultra-Compact Regenerative Liver Dialysis Device

The availability of a wearable artificial liver that facilitates extracorporeal dialysis outside of medical facilities would represent a significant advancement for patients requiring dialysis. The objective of this preliminary investigation is to explore, using validated mathematical models based o...

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Detalles Bibliográficos
Autores principales: Boscarino, Tamara, Mazzeo, Leone, Abbruzzese, Franca, Merone, Mario, Piemonte, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295730/
https://www.ncbi.nlm.nih.gov/pubmed/37370637
http://dx.doi.org/10.3390/bioengineering10060706
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author Boscarino, Tamara
Mazzeo, Leone
Abbruzzese, Franca
Merone, Mario
Piemonte, Vincenzo
author_facet Boscarino, Tamara
Mazzeo, Leone
Abbruzzese, Franca
Merone, Mario
Piemonte, Vincenzo
author_sort Boscarino, Tamara
collection PubMed
description The availability of a wearable artificial liver that facilitates extracorporeal dialysis outside of medical facilities would represent a significant advancement for patients requiring dialysis. The objective of this preliminary investigation is to explore, using validated mathematical models based on in vitro data, the feasibility of developing a novel, cost-effective, and highly compact extracorporeal liver support device that can be employed as a transitional therapy to transplantation outside of clinical settings. Such an innovation would offer substantial cost savings to the national healthcare system while significantly improving the patient’s quality of life. The experimental components consisted of replacing traditional adsorbent materials with albumin-functionalized silica microspheres due to their capacity to adsorb bilirubin, one of the toxins responsible for liver failure. Two configurations of the dialysis module were tested: one involved dispersing the adsorbent particles in dialysis fluid, while the other did not require dialysis fluid. The results demonstrate the superior performance of the first configuration compared to the second. Although the clinical applicability of these models remains distant from the current stage, further studies will focus on optimizing these models to develop a more compact and wearable device.
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spelling pubmed-102957302023-06-28 Modeling and Validation of an Ultra-Compact Regenerative Liver Dialysis Device Boscarino, Tamara Mazzeo, Leone Abbruzzese, Franca Merone, Mario Piemonte, Vincenzo Bioengineering (Basel) Article The availability of a wearable artificial liver that facilitates extracorporeal dialysis outside of medical facilities would represent a significant advancement for patients requiring dialysis. The objective of this preliminary investigation is to explore, using validated mathematical models based on in vitro data, the feasibility of developing a novel, cost-effective, and highly compact extracorporeal liver support device that can be employed as a transitional therapy to transplantation outside of clinical settings. Such an innovation would offer substantial cost savings to the national healthcare system while significantly improving the patient’s quality of life. The experimental components consisted of replacing traditional adsorbent materials with albumin-functionalized silica microspheres due to their capacity to adsorb bilirubin, one of the toxins responsible for liver failure. Two configurations of the dialysis module were tested: one involved dispersing the adsorbent particles in dialysis fluid, while the other did not require dialysis fluid. The results demonstrate the superior performance of the first configuration compared to the second. Although the clinical applicability of these models remains distant from the current stage, further studies will focus on optimizing these models to develop a more compact and wearable device. MDPI 2023-06-11 /pmc/articles/PMC10295730/ /pubmed/37370637 http://dx.doi.org/10.3390/bioengineering10060706 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boscarino, Tamara
Mazzeo, Leone
Abbruzzese, Franca
Merone, Mario
Piemonte, Vincenzo
Modeling and Validation of an Ultra-Compact Regenerative Liver Dialysis Device
title Modeling and Validation of an Ultra-Compact Regenerative Liver Dialysis Device
title_full Modeling and Validation of an Ultra-Compact Regenerative Liver Dialysis Device
title_fullStr Modeling and Validation of an Ultra-Compact Regenerative Liver Dialysis Device
title_full_unstemmed Modeling and Validation of an Ultra-Compact Regenerative Liver Dialysis Device
title_short Modeling and Validation of an Ultra-Compact Regenerative Liver Dialysis Device
title_sort modeling and validation of an ultra-compact regenerative liver dialysis device
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295730/
https://www.ncbi.nlm.nih.gov/pubmed/37370637
http://dx.doi.org/10.3390/bioengineering10060706
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