Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023

Periprosthetic joint infection (PJI) is a rare yet devastating complication following total joint arthroplasty (TJA). Early and accurate diagnosis of PJI is paramount in order to maximize the chances of successful treatment. However, we are yet to identify a single “gold standard” test for the diagn...

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Autores principales: Yilmaz, Mehmet Kursat, Abbaszadeh, Ahmad, Tarabichi, Saad, Azboy, Ibrahim, Parvizi, Javad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295740/
https://www.ncbi.nlm.nih.gov/pubmed/37370373
http://dx.doi.org/10.3390/antibiotics12061054
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author Yilmaz, Mehmet Kursat
Abbaszadeh, Ahmad
Tarabichi, Saad
Azboy, Ibrahim
Parvizi, Javad
author_facet Yilmaz, Mehmet Kursat
Abbaszadeh, Ahmad
Tarabichi, Saad
Azboy, Ibrahim
Parvizi, Javad
author_sort Yilmaz, Mehmet Kursat
collection PubMed
description Periprosthetic joint infection (PJI) is a rare yet devastating complication following total joint arthroplasty (TJA). Early and accurate diagnosis of PJI is paramount in order to maximize the chances of successful treatment. However, we are yet to identify a single “gold standard” test for the diagnosis of PJI. As a result, the diagnosis of PJI is often challenging. Currently, the 2018 ICM definition of PJI is the only validated diagnostic criteria available. This article will review the importance of serum and synovial biomarkers in the diagnosis of PJI. In addition, it will provide a brief overview of the emerging modalities for the identification of infections in this setting.
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spelling pubmed-102957402023-06-28 Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023 Yilmaz, Mehmet Kursat Abbaszadeh, Ahmad Tarabichi, Saad Azboy, Ibrahim Parvizi, Javad Antibiotics (Basel) Review Periprosthetic joint infection (PJI) is a rare yet devastating complication following total joint arthroplasty (TJA). Early and accurate diagnosis of PJI is paramount in order to maximize the chances of successful treatment. However, we are yet to identify a single “gold standard” test for the diagnosis of PJI. As a result, the diagnosis of PJI is often challenging. Currently, the 2018 ICM definition of PJI is the only validated diagnostic criteria available. This article will review the importance of serum and synovial biomarkers in the diagnosis of PJI. In addition, it will provide a brief overview of the emerging modalities for the identification of infections in this setting. MDPI 2023-06-15 /pmc/articles/PMC10295740/ /pubmed/37370373 http://dx.doi.org/10.3390/antibiotics12061054 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yilmaz, Mehmet Kursat
Abbaszadeh, Ahmad
Tarabichi, Saad
Azboy, Ibrahim
Parvizi, Javad
Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023
title Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023
title_full Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023
title_fullStr Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023
title_full_unstemmed Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023
title_short Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023
title_sort diagnosis of periprosthetic joint infection: the utility of biomarkers in 2023
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295740/
https://www.ncbi.nlm.nih.gov/pubmed/37370373
http://dx.doi.org/10.3390/antibiotics12061054
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