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Cannabis for the Treatment of Fibromyalgia: A Systematic Review
Fibromyalgia is a common disease syndrome characterized by chronic pain and fatigue in conjunction with cognitive dysfunction such as memory difficulties. Patients currently face a difficult prognosis with limited treatment options and a diminished quality of life. Given its widespread use and poten...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295750/ https://www.ncbi.nlm.nih.gov/pubmed/37371716 http://dx.doi.org/10.3390/biomedicines11061621 |
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author | Strand, Natalie H. Maloney, Jillian Kraus, Molly Wie, Christopher Turkiewicz, Michal Gomez, Diego A. Adeleye, Olufunmilola Harbell, Monica W. |
author_facet | Strand, Natalie H. Maloney, Jillian Kraus, Molly Wie, Christopher Turkiewicz, Michal Gomez, Diego A. Adeleye, Olufunmilola Harbell, Monica W. |
author_sort | Strand, Natalie H. |
collection | PubMed |
description | Fibromyalgia is a common disease syndrome characterized by chronic pain and fatigue in conjunction with cognitive dysfunction such as memory difficulties. Patients currently face a difficult prognosis with limited treatment options and a diminished quality of life. Given its widespread use and potential efficacy in treating other types of pain, cannabis may prove to be an effective treatment for fibromyalgia. This review aims to examine and discuss current clinical evidence regarding the use of cannabis for the treatment of fibromyalgia. An electronic search was conducted on MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus using Medical Subject Heading (MeSH) terms on all literature published up to October 2022. A follow-up manual search included a complete verification of relevant studies. The results of four randomized controlled trials (RCTs) and five observational studies (a total of 564 patients) that investigated the effects of cannabis on fibromyalgia symptoms were included in this review. Of the RCTs, only one demonstrated that cannabinoids did not have a different effect than placebo on pain responses. Overall, this analysis shows low-quality evidence supporting short-term pain reduction in people with fibromyalgia treated with cannabinoid therapeutics. Although current evidence is limited, medical cannabis appears to be a safe alternative for treating fibromyalgia. |
format | Online Article Text |
id | pubmed-10295750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102957502023-06-28 Cannabis for the Treatment of Fibromyalgia: A Systematic Review Strand, Natalie H. Maloney, Jillian Kraus, Molly Wie, Christopher Turkiewicz, Michal Gomez, Diego A. Adeleye, Olufunmilola Harbell, Monica W. Biomedicines Systematic Review Fibromyalgia is a common disease syndrome characterized by chronic pain and fatigue in conjunction with cognitive dysfunction such as memory difficulties. Patients currently face a difficult prognosis with limited treatment options and a diminished quality of life. Given its widespread use and potential efficacy in treating other types of pain, cannabis may prove to be an effective treatment for fibromyalgia. This review aims to examine and discuss current clinical evidence regarding the use of cannabis for the treatment of fibromyalgia. An electronic search was conducted on MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus using Medical Subject Heading (MeSH) terms on all literature published up to October 2022. A follow-up manual search included a complete verification of relevant studies. The results of four randomized controlled trials (RCTs) and five observational studies (a total of 564 patients) that investigated the effects of cannabis on fibromyalgia symptoms were included in this review. Of the RCTs, only one demonstrated that cannabinoids did not have a different effect than placebo on pain responses. Overall, this analysis shows low-quality evidence supporting short-term pain reduction in people with fibromyalgia treated with cannabinoid therapeutics. Although current evidence is limited, medical cannabis appears to be a safe alternative for treating fibromyalgia. MDPI 2023-06-02 /pmc/articles/PMC10295750/ /pubmed/37371716 http://dx.doi.org/10.3390/biomedicines11061621 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Strand, Natalie H. Maloney, Jillian Kraus, Molly Wie, Christopher Turkiewicz, Michal Gomez, Diego A. Adeleye, Olufunmilola Harbell, Monica W. Cannabis for the Treatment of Fibromyalgia: A Systematic Review |
title | Cannabis for the Treatment of Fibromyalgia: A Systematic Review |
title_full | Cannabis for the Treatment of Fibromyalgia: A Systematic Review |
title_fullStr | Cannabis for the Treatment of Fibromyalgia: A Systematic Review |
title_full_unstemmed | Cannabis for the Treatment of Fibromyalgia: A Systematic Review |
title_short | Cannabis for the Treatment of Fibromyalgia: A Systematic Review |
title_sort | cannabis for the treatment of fibromyalgia: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295750/ https://www.ncbi.nlm.nih.gov/pubmed/37371716 http://dx.doi.org/10.3390/biomedicines11061621 |
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