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Cannabis for the Treatment of Fibromyalgia: A Systematic Review

Fibromyalgia is a common disease syndrome characterized by chronic pain and fatigue in conjunction with cognitive dysfunction such as memory difficulties. Patients currently face a difficult prognosis with limited treatment options and a diminished quality of life. Given its widespread use and poten...

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Autores principales: Strand, Natalie H., Maloney, Jillian, Kraus, Molly, Wie, Christopher, Turkiewicz, Michal, Gomez, Diego A., Adeleye, Olufunmilola, Harbell, Monica W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295750/
https://www.ncbi.nlm.nih.gov/pubmed/37371716
http://dx.doi.org/10.3390/biomedicines11061621
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author Strand, Natalie H.
Maloney, Jillian
Kraus, Molly
Wie, Christopher
Turkiewicz, Michal
Gomez, Diego A.
Adeleye, Olufunmilola
Harbell, Monica W.
author_facet Strand, Natalie H.
Maloney, Jillian
Kraus, Molly
Wie, Christopher
Turkiewicz, Michal
Gomez, Diego A.
Adeleye, Olufunmilola
Harbell, Monica W.
author_sort Strand, Natalie H.
collection PubMed
description Fibromyalgia is a common disease syndrome characterized by chronic pain and fatigue in conjunction with cognitive dysfunction such as memory difficulties. Patients currently face a difficult prognosis with limited treatment options and a diminished quality of life. Given its widespread use and potential efficacy in treating other types of pain, cannabis may prove to be an effective treatment for fibromyalgia. This review aims to examine and discuss current clinical evidence regarding the use of cannabis for the treatment of fibromyalgia. An electronic search was conducted on MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus using Medical Subject Heading (MeSH) terms on all literature published up to October 2022. A follow-up manual search included a complete verification of relevant studies. The results of four randomized controlled trials (RCTs) and five observational studies (a total of 564 patients) that investigated the effects of cannabis on fibromyalgia symptoms were included in this review. Of the RCTs, only one demonstrated that cannabinoids did not have a different effect than placebo on pain responses. Overall, this analysis shows low-quality evidence supporting short-term pain reduction in people with fibromyalgia treated with cannabinoid therapeutics. Although current evidence is limited, medical cannabis appears to be a safe alternative for treating fibromyalgia.
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spelling pubmed-102957502023-06-28 Cannabis for the Treatment of Fibromyalgia: A Systematic Review Strand, Natalie H. Maloney, Jillian Kraus, Molly Wie, Christopher Turkiewicz, Michal Gomez, Diego A. Adeleye, Olufunmilola Harbell, Monica W. Biomedicines Systematic Review Fibromyalgia is a common disease syndrome characterized by chronic pain and fatigue in conjunction with cognitive dysfunction such as memory difficulties. Patients currently face a difficult prognosis with limited treatment options and a diminished quality of life. Given its widespread use and potential efficacy in treating other types of pain, cannabis may prove to be an effective treatment for fibromyalgia. This review aims to examine and discuss current clinical evidence regarding the use of cannabis for the treatment of fibromyalgia. An electronic search was conducted on MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus using Medical Subject Heading (MeSH) terms on all literature published up to October 2022. A follow-up manual search included a complete verification of relevant studies. The results of four randomized controlled trials (RCTs) and five observational studies (a total of 564 patients) that investigated the effects of cannabis on fibromyalgia symptoms were included in this review. Of the RCTs, only one demonstrated that cannabinoids did not have a different effect than placebo on pain responses. Overall, this analysis shows low-quality evidence supporting short-term pain reduction in people with fibromyalgia treated with cannabinoid therapeutics. Although current evidence is limited, medical cannabis appears to be a safe alternative for treating fibromyalgia. MDPI 2023-06-02 /pmc/articles/PMC10295750/ /pubmed/37371716 http://dx.doi.org/10.3390/biomedicines11061621 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Strand, Natalie H.
Maloney, Jillian
Kraus, Molly
Wie, Christopher
Turkiewicz, Michal
Gomez, Diego A.
Adeleye, Olufunmilola
Harbell, Monica W.
Cannabis for the Treatment of Fibromyalgia: A Systematic Review
title Cannabis for the Treatment of Fibromyalgia: A Systematic Review
title_full Cannabis for the Treatment of Fibromyalgia: A Systematic Review
title_fullStr Cannabis for the Treatment of Fibromyalgia: A Systematic Review
title_full_unstemmed Cannabis for the Treatment of Fibromyalgia: A Systematic Review
title_short Cannabis for the Treatment of Fibromyalgia: A Systematic Review
title_sort cannabis for the treatment of fibromyalgia: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295750/
https://www.ncbi.nlm.nih.gov/pubmed/37371716
http://dx.doi.org/10.3390/biomedicines11061621
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