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Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa
Helicobacter pylori (H. pylori) infection is ubiquitous worldwide, with prevalence rates of greater than 70% in Africa. Symptomatic patients present with foregut gastrointestinal symptoms which can be readily diagnosed with standardized non-invasive or invasive tests. The biggest challenge, however,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295761/ https://www.ncbi.nlm.nih.gov/pubmed/37370288 http://dx.doi.org/10.3390/antibiotics12060969 |
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author | Setshedi, Mashiko Smith, Stella I. |
author_facet | Setshedi, Mashiko Smith, Stella I. |
author_sort | Setshedi, Mashiko |
collection | PubMed |
description | Helicobacter pylori (H. pylori) infection is ubiquitous worldwide, with prevalence rates of greater than 70% in Africa. Symptomatic patients present with foregut gastrointestinal symptoms which can be readily diagnosed with standardized non-invasive or invasive tests. The biggest challenge, however, is in the management of this condition with rising antimicrobial resistance rates to most of the antibiotics recommended for therapy. This is a problem worldwide, but more specifically in Africa, where the socio-economic and political climate is such that eradication of this organism seems impossible. Furthermore, the recommended antimicrobial susceptibility testing for drug resistance is not widely available in Africa due to the lack of infrastructural as well as human resources. With the widespread unregulated use of antibiotics in some parts of Africa, the figures of antimicrobial resistance are likely to soar. In the face of these significant challenges, this ‘perspectives’ article aims to address the issue of antimicrobial resistance in Africa, by providing achievable and targeted goals to curb the spread of infection and rising antimicrobial resistance. |
format | Online Article Text |
id | pubmed-10295761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102957612023-06-28 Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa Setshedi, Mashiko Smith, Stella I. Antibiotics (Basel) Perspective Helicobacter pylori (H. pylori) infection is ubiquitous worldwide, with prevalence rates of greater than 70% in Africa. Symptomatic patients present with foregut gastrointestinal symptoms which can be readily diagnosed with standardized non-invasive or invasive tests. The biggest challenge, however, is in the management of this condition with rising antimicrobial resistance rates to most of the antibiotics recommended for therapy. This is a problem worldwide, but more specifically in Africa, where the socio-economic and political climate is such that eradication of this organism seems impossible. Furthermore, the recommended antimicrobial susceptibility testing for drug resistance is not widely available in Africa due to the lack of infrastructural as well as human resources. With the widespread unregulated use of antibiotics in some parts of Africa, the figures of antimicrobial resistance are likely to soar. In the face of these significant challenges, this ‘perspectives’ article aims to address the issue of antimicrobial resistance in Africa, by providing achievable and targeted goals to curb the spread of infection and rising antimicrobial resistance. MDPI 2023-05-26 /pmc/articles/PMC10295761/ /pubmed/37370288 http://dx.doi.org/10.3390/antibiotics12060969 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Setshedi, Mashiko Smith, Stella I. Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa |
title | Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa |
title_full | Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa |
title_fullStr | Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa |
title_full_unstemmed | Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa |
title_short | Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa |
title_sort | helicobacter pylori infection: antibiotic resistance and solutions for effective management in africa |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295761/ https://www.ncbi.nlm.nih.gov/pubmed/37370288 http://dx.doi.org/10.3390/antibiotics12060969 |
work_keys_str_mv | AT setshedimashiko helicobacterpyloriinfectionantibioticresistanceandsolutionsforeffectivemanagementinafrica AT smithstellai helicobacterpyloriinfectionantibioticresistanceandsolutionsforeffectivemanagementinafrica |