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Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa

Helicobacter pylori (H. pylori) infection is ubiquitous worldwide, with prevalence rates of greater than 70% in Africa. Symptomatic patients present with foregut gastrointestinal symptoms which can be readily diagnosed with standardized non-invasive or invasive tests. The biggest challenge, however,...

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Autores principales: Setshedi, Mashiko, Smith, Stella I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295761/
https://www.ncbi.nlm.nih.gov/pubmed/37370288
http://dx.doi.org/10.3390/antibiotics12060969
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author Setshedi, Mashiko
Smith, Stella I.
author_facet Setshedi, Mashiko
Smith, Stella I.
author_sort Setshedi, Mashiko
collection PubMed
description Helicobacter pylori (H. pylori) infection is ubiquitous worldwide, with prevalence rates of greater than 70% in Africa. Symptomatic patients present with foregut gastrointestinal symptoms which can be readily diagnosed with standardized non-invasive or invasive tests. The biggest challenge, however, is in the management of this condition with rising antimicrobial resistance rates to most of the antibiotics recommended for therapy. This is a problem worldwide, but more specifically in Africa, where the socio-economic and political climate is such that eradication of this organism seems impossible. Furthermore, the recommended antimicrobial susceptibility testing for drug resistance is not widely available in Africa due to the lack of infrastructural as well as human resources. With the widespread unregulated use of antibiotics in some parts of Africa, the figures of antimicrobial resistance are likely to soar. In the face of these significant challenges, this ‘perspectives’ article aims to address the issue of antimicrobial resistance in Africa, by providing achievable and targeted goals to curb the spread of infection and rising antimicrobial resistance.
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spelling pubmed-102957612023-06-28 Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa Setshedi, Mashiko Smith, Stella I. Antibiotics (Basel) Perspective Helicobacter pylori (H. pylori) infection is ubiquitous worldwide, with prevalence rates of greater than 70% in Africa. Symptomatic patients present with foregut gastrointestinal symptoms which can be readily diagnosed with standardized non-invasive or invasive tests. The biggest challenge, however, is in the management of this condition with rising antimicrobial resistance rates to most of the antibiotics recommended for therapy. This is a problem worldwide, but more specifically in Africa, where the socio-economic and political climate is such that eradication of this organism seems impossible. Furthermore, the recommended antimicrobial susceptibility testing for drug resistance is not widely available in Africa due to the lack of infrastructural as well as human resources. With the widespread unregulated use of antibiotics in some parts of Africa, the figures of antimicrobial resistance are likely to soar. In the face of these significant challenges, this ‘perspectives’ article aims to address the issue of antimicrobial resistance in Africa, by providing achievable and targeted goals to curb the spread of infection and rising antimicrobial resistance. MDPI 2023-05-26 /pmc/articles/PMC10295761/ /pubmed/37370288 http://dx.doi.org/10.3390/antibiotics12060969 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Setshedi, Mashiko
Smith, Stella I.
Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa
title Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa
title_full Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa
title_fullStr Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa
title_full_unstemmed Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa
title_short Helicobacter pylori Infection: Antibiotic Resistance and Solutions for Effective Management in Africa
title_sort helicobacter pylori infection: antibiotic resistance and solutions for effective management in africa
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295761/
https://www.ncbi.nlm.nih.gov/pubmed/37370288
http://dx.doi.org/10.3390/antibiotics12060969
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