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Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration

Osteoporosis is a disease characterised by a reduction in bone strength due to increased porosity and impaired mineralisation. In our study, we investigated whether muscle strength and mass exert a significant effect on bone mineral density in young adult women. We also tested whether sclerostin can...

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Autores principales: Patalong-Wójcik, Martyna, Golara, Anna, Zając, Katarzyna, Sokołowska, Alicja, Kozłowski, Mateusz, Tołoczko-Grabarek, Aleksandra, Krzyścin, Mariola, Brodowska, Agnieszka, Janiec, Agnieszka, Myszka, Aleksandra, Cymbaluk-Płoska, Aneta, Sowińska-Przepiera, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295770/
https://www.ncbi.nlm.nih.gov/pubmed/37371669
http://dx.doi.org/10.3390/biomedicines11061574
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author Patalong-Wójcik, Martyna
Golara, Anna
Zając, Katarzyna
Sokołowska, Alicja
Kozłowski, Mateusz
Tołoczko-Grabarek, Aleksandra
Krzyścin, Mariola
Brodowska, Agnieszka
Janiec, Agnieszka
Myszka, Aleksandra
Cymbaluk-Płoska, Aneta
Sowińska-Przepiera, Elżbieta
author_facet Patalong-Wójcik, Martyna
Golara, Anna
Zając, Katarzyna
Sokołowska, Alicja
Kozłowski, Mateusz
Tołoczko-Grabarek, Aleksandra
Krzyścin, Mariola
Brodowska, Agnieszka
Janiec, Agnieszka
Myszka, Aleksandra
Cymbaluk-Płoska, Aneta
Sowińska-Przepiera, Elżbieta
author_sort Patalong-Wójcik, Martyna
collection PubMed
description Osteoporosis is a disease characterised by a reduction in bone strength due to increased porosity and impaired mineralisation. In our study, we investigated whether muscle strength and mass exert a significant effect on bone mineral density in young adult women. We also tested whether sclerostin can be used as an indicator in the assessment of bone mineralisation. The study included 111 patients. All patients had their bone mineral density determined in the L1–L4 section of the lumbar spine and in the whole skeleton. The parameters of fat mass (FM), lean body mass (LBM) and visceral fat mass (VF) were also determined. Metabolic activity of osteocytes was assessed by measuring the serum sclerostin concentration. There was a statistically significant association of both hands’ muscle strength with all parameters expressing bone mineralisation. A statistically significant relationship was also obtained between BMD L1–L4 and the body mass components (FM, LBM). Sclerostin levels in the study did not differ between groups with normal and reduced bone mineral density. Muscle strength assessment may be a potential exponent of reduced bone mineral density, also used clinically in young adult women. The utility of sclerostin in the clinical assessment of bone mineralisation has not been demonstrated.
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spelling pubmed-102957702023-06-28 Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration Patalong-Wójcik, Martyna Golara, Anna Zając, Katarzyna Sokołowska, Alicja Kozłowski, Mateusz Tołoczko-Grabarek, Aleksandra Krzyścin, Mariola Brodowska, Agnieszka Janiec, Agnieszka Myszka, Aleksandra Cymbaluk-Płoska, Aneta Sowińska-Przepiera, Elżbieta Biomedicines Article Osteoporosis is a disease characterised by a reduction in bone strength due to increased porosity and impaired mineralisation. In our study, we investigated whether muscle strength and mass exert a significant effect on bone mineral density in young adult women. We also tested whether sclerostin can be used as an indicator in the assessment of bone mineralisation. The study included 111 patients. All patients had their bone mineral density determined in the L1–L4 section of the lumbar spine and in the whole skeleton. The parameters of fat mass (FM), lean body mass (LBM) and visceral fat mass (VF) were also determined. Metabolic activity of osteocytes was assessed by measuring the serum sclerostin concentration. There was a statistically significant association of both hands’ muscle strength with all parameters expressing bone mineralisation. A statistically significant relationship was also obtained between BMD L1–L4 and the body mass components (FM, LBM). Sclerostin levels in the study did not differ between groups with normal and reduced bone mineral density. Muscle strength assessment may be a potential exponent of reduced bone mineral density, also used clinically in young adult women. The utility of sclerostin in the clinical assessment of bone mineralisation has not been demonstrated. MDPI 2023-05-29 /pmc/articles/PMC10295770/ /pubmed/37371669 http://dx.doi.org/10.3390/biomedicines11061574 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Patalong-Wójcik, Martyna
Golara, Anna
Zając, Katarzyna
Sokołowska, Alicja
Kozłowski, Mateusz
Tołoczko-Grabarek, Aleksandra
Krzyścin, Mariola
Brodowska, Agnieszka
Janiec, Agnieszka
Myszka, Aleksandra
Cymbaluk-Płoska, Aneta
Sowińska-Przepiera, Elżbieta
Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration
title Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration
title_full Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration
title_fullStr Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration
title_full_unstemmed Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration
title_short Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration
title_sort influence of muscle mass and strength on bone mineralisation with consideration of sclerostin concentration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295770/
https://www.ncbi.nlm.nih.gov/pubmed/37371669
http://dx.doi.org/10.3390/biomedicines11061574
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