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Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration
Osteoporosis is a disease characterised by a reduction in bone strength due to increased porosity and impaired mineralisation. In our study, we investigated whether muscle strength and mass exert a significant effect on bone mineral density in young adult women. We also tested whether sclerostin can...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295770/ https://www.ncbi.nlm.nih.gov/pubmed/37371669 http://dx.doi.org/10.3390/biomedicines11061574 |
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author | Patalong-Wójcik, Martyna Golara, Anna Zając, Katarzyna Sokołowska, Alicja Kozłowski, Mateusz Tołoczko-Grabarek, Aleksandra Krzyścin, Mariola Brodowska, Agnieszka Janiec, Agnieszka Myszka, Aleksandra Cymbaluk-Płoska, Aneta Sowińska-Przepiera, Elżbieta |
author_facet | Patalong-Wójcik, Martyna Golara, Anna Zając, Katarzyna Sokołowska, Alicja Kozłowski, Mateusz Tołoczko-Grabarek, Aleksandra Krzyścin, Mariola Brodowska, Agnieszka Janiec, Agnieszka Myszka, Aleksandra Cymbaluk-Płoska, Aneta Sowińska-Przepiera, Elżbieta |
author_sort | Patalong-Wójcik, Martyna |
collection | PubMed |
description | Osteoporosis is a disease characterised by a reduction in bone strength due to increased porosity and impaired mineralisation. In our study, we investigated whether muscle strength and mass exert a significant effect on bone mineral density in young adult women. We also tested whether sclerostin can be used as an indicator in the assessment of bone mineralisation. The study included 111 patients. All patients had their bone mineral density determined in the L1–L4 section of the lumbar spine and in the whole skeleton. The parameters of fat mass (FM), lean body mass (LBM) and visceral fat mass (VF) were also determined. Metabolic activity of osteocytes was assessed by measuring the serum sclerostin concentration. There was a statistically significant association of both hands’ muscle strength with all parameters expressing bone mineralisation. A statistically significant relationship was also obtained between BMD L1–L4 and the body mass components (FM, LBM). Sclerostin levels in the study did not differ between groups with normal and reduced bone mineral density. Muscle strength assessment may be a potential exponent of reduced bone mineral density, also used clinically in young adult women. The utility of sclerostin in the clinical assessment of bone mineralisation has not been demonstrated. |
format | Online Article Text |
id | pubmed-10295770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102957702023-06-28 Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration Patalong-Wójcik, Martyna Golara, Anna Zając, Katarzyna Sokołowska, Alicja Kozłowski, Mateusz Tołoczko-Grabarek, Aleksandra Krzyścin, Mariola Brodowska, Agnieszka Janiec, Agnieszka Myszka, Aleksandra Cymbaluk-Płoska, Aneta Sowińska-Przepiera, Elżbieta Biomedicines Article Osteoporosis is a disease characterised by a reduction in bone strength due to increased porosity and impaired mineralisation. In our study, we investigated whether muscle strength and mass exert a significant effect on bone mineral density in young adult women. We also tested whether sclerostin can be used as an indicator in the assessment of bone mineralisation. The study included 111 patients. All patients had their bone mineral density determined in the L1–L4 section of the lumbar spine and in the whole skeleton. The parameters of fat mass (FM), lean body mass (LBM) and visceral fat mass (VF) were also determined. Metabolic activity of osteocytes was assessed by measuring the serum sclerostin concentration. There was a statistically significant association of both hands’ muscle strength with all parameters expressing bone mineralisation. A statistically significant relationship was also obtained between BMD L1–L4 and the body mass components (FM, LBM). Sclerostin levels in the study did not differ between groups with normal and reduced bone mineral density. Muscle strength assessment may be a potential exponent of reduced bone mineral density, also used clinically in young adult women. The utility of sclerostin in the clinical assessment of bone mineralisation has not been demonstrated. MDPI 2023-05-29 /pmc/articles/PMC10295770/ /pubmed/37371669 http://dx.doi.org/10.3390/biomedicines11061574 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Patalong-Wójcik, Martyna Golara, Anna Zając, Katarzyna Sokołowska, Alicja Kozłowski, Mateusz Tołoczko-Grabarek, Aleksandra Krzyścin, Mariola Brodowska, Agnieszka Janiec, Agnieszka Myszka, Aleksandra Cymbaluk-Płoska, Aneta Sowińska-Przepiera, Elżbieta Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration |
title | Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration |
title_full | Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration |
title_fullStr | Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration |
title_full_unstemmed | Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration |
title_short | Influence of Muscle Mass and Strength on Bone Mineralisation with Consideration of Sclerostin Concentration |
title_sort | influence of muscle mass and strength on bone mineralisation with consideration of sclerostin concentration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295770/ https://www.ncbi.nlm.nih.gov/pubmed/37371669 http://dx.doi.org/10.3390/biomedicines11061574 |
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