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Role of inflammasomes in neuroinflammation after ischemic stroke
Ischemic stroke is a devastating disease for which there is no effective medical treatment. In the era of extensive reperfusion strategies, established neuroprotectant candidates and novel therapeutic drugs with better targets are promising for treatment of acute ischemic stroke. Such targets includ...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Encephalitis and Neuroinflammation Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295893/ https://www.ncbi.nlm.nih.gov/pubmed/37470048 http://dx.doi.org/10.47936/encephalitis.2021.00073 |
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author | Jung, Keun-Hwa Seong, Seung-Yong |
author_facet | Jung, Keun-Hwa Seong, Seung-Yong |
author_sort | Jung, Keun-Hwa |
collection | PubMed |
description | Ischemic stroke is a devastating disease for which there is no effective medical treatment. In the era of extensive reperfusion strategies, established neuroprotectant candidates and novel therapeutic drugs with better targets are promising for treatment of acute ischemic stroke. Such targets include the inflammasome pathway, which contributes significantly to the pathogenesis of ischemic stroke. Following ischemic stroke, damage-associated molecular patterns from damaged cells activate inflammasomes, incur inflammatory responses, and induce cell death. Therefore, inhibiting inflammasome pathways has great promise for treatment of ischemic stroke. However, the efficacy and safety of inflammasome inhibitors remain controversial, and better upstream targets are needed for effective modulation. Herein, the roles of the inflammasome in ischemic injury caused by stroke are reviewed and the potential of neuroprotectants targeting the inflammasome is discussed. |
format | Online Article Text |
id | pubmed-10295893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Encephalitis and Neuroinflammation Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-102958932023-07-19 Role of inflammasomes in neuroinflammation after ischemic stroke Jung, Keun-Hwa Seong, Seung-Yong Encephalitis Review Article Ischemic stroke is a devastating disease for which there is no effective medical treatment. In the era of extensive reperfusion strategies, established neuroprotectant candidates and novel therapeutic drugs with better targets are promising for treatment of acute ischemic stroke. Such targets include the inflammasome pathway, which contributes significantly to the pathogenesis of ischemic stroke. Following ischemic stroke, damage-associated molecular patterns from damaged cells activate inflammasomes, incur inflammatory responses, and induce cell death. Therefore, inhibiting inflammasome pathways has great promise for treatment of ischemic stroke. However, the efficacy and safety of inflammasome inhibitors remain controversial, and better upstream targets are needed for effective modulation. Herein, the roles of the inflammasome in ischemic injury caused by stroke are reviewed and the potential of neuroprotectants targeting the inflammasome is discussed. Korean Encephalitis and Neuroinflammation Society 2021-10 2021-06-07 /pmc/articles/PMC10295893/ /pubmed/37470048 http://dx.doi.org/10.47936/encephalitis.2021.00073 Text en Copyright © 2021 Korean Encephalitis and Neuroinflammation Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jung, Keun-Hwa Seong, Seung-Yong Role of inflammasomes in neuroinflammation after ischemic stroke |
title | Role of inflammasomes in neuroinflammation after ischemic stroke |
title_full | Role of inflammasomes in neuroinflammation after ischemic stroke |
title_fullStr | Role of inflammasomes in neuroinflammation after ischemic stroke |
title_full_unstemmed | Role of inflammasomes in neuroinflammation after ischemic stroke |
title_short | Role of inflammasomes in neuroinflammation after ischemic stroke |
title_sort | role of inflammasomes in neuroinflammation after ischemic stroke |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295893/ https://www.ncbi.nlm.nih.gov/pubmed/37470048 http://dx.doi.org/10.47936/encephalitis.2021.00073 |
work_keys_str_mv | AT jungkeunhwa roleofinflammasomesinneuroinflammationafterischemicstroke AT seongseungyong roleofinflammasomesinneuroinflammationafterischemicstroke |