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Role of inflammasomes in neuroinflammation after ischemic stroke

Ischemic stroke is a devastating disease for which there is no effective medical treatment. In the era of extensive reperfusion strategies, established neuroprotectant candidates and novel therapeutic drugs with better targets are promising for treatment of acute ischemic stroke. Such targets includ...

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Autores principales: Jung, Keun-Hwa, Seong, Seung-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Encephalitis and Neuroinflammation Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295893/
https://www.ncbi.nlm.nih.gov/pubmed/37470048
http://dx.doi.org/10.47936/encephalitis.2021.00073
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author Jung, Keun-Hwa
Seong, Seung-Yong
author_facet Jung, Keun-Hwa
Seong, Seung-Yong
author_sort Jung, Keun-Hwa
collection PubMed
description Ischemic stroke is a devastating disease for which there is no effective medical treatment. In the era of extensive reperfusion strategies, established neuroprotectant candidates and novel therapeutic drugs with better targets are promising for treatment of acute ischemic stroke. Such targets include the inflammasome pathway, which contributes significantly to the pathogenesis of ischemic stroke. Following ischemic stroke, damage-associated molecular patterns from damaged cells activate inflammasomes, incur inflammatory responses, and induce cell death. Therefore, inhibiting inflammasome pathways has great promise for treatment of ischemic stroke. However, the efficacy and safety of inflammasome inhibitors remain controversial, and better upstream targets are needed for effective modulation. Herein, the roles of the inflammasome in ischemic injury caused by stroke are reviewed and the potential of neuroprotectants targeting the inflammasome is discussed.
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spelling pubmed-102958932023-07-19 Role of inflammasomes in neuroinflammation after ischemic stroke Jung, Keun-Hwa Seong, Seung-Yong Encephalitis Review Article Ischemic stroke is a devastating disease for which there is no effective medical treatment. In the era of extensive reperfusion strategies, established neuroprotectant candidates and novel therapeutic drugs with better targets are promising for treatment of acute ischemic stroke. Such targets include the inflammasome pathway, which contributes significantly to the pathogenesis of ischemic stroke. Following ischemic stroke, damage-associated molecular patterns from damaged cells activate inflammasomes, incur inflammatory responses, and induce cell death. Therefore, inhibiting inflammasome pathways has great promise for treatment of ischemic stroke. However, the efficacy and safety of inflammasome inhibitors remain controversial, and better upstream targets are needed for effective modulation. Herein, the roles of the inflammasome in ischemic injury caused by stroke are reviewed and the potential of neuroprotectants targeting the inflammasome is discussed. Korean Encephalitis and Neuroinflammation Society 2021-10 2021-06-07 /pmc/articles/PMC10295893/ /pubmed/37470048 http://dx.doi.org/10.47936/encephalitis.2021.00073 Text en Copyright © 2021 Korean Encephalitis and Neuroinflammation Society https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jung, Keun-Hwa
Seong, Seung-Yong
Role of inflammasomes in neuroinflammation after ischemic stroke
title Role of inflammasomes in neuroinflammation after ischemic stroke
title_full Role of inflammasomes in neuroinflammation after ischemic stroke
title_fullStr Role of inflammasomes in neuroinflammation after ischemic stroke
title_full_unstemmed Role of inflammasomes in neuroinflammation after ischemic stroke
title_short Role of inflammasomes in neuroinflammation after ischemic stroke
title_sort role of inflammasomes in neuroinflammation after ischemic stroke
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295893/
https://www.ncbi.nlm.nih.gov/pubmed/37470048
http://dx.doi.org/10.47936/encephalitis.2021.00073
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