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A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination
Polyion complex (PIC) materials have been widely used in biosensors due to their molecular selectivity. However, achieving both widely controllable molecular selectivity and long-term solution stability with traditional PIC materials has been challenging due to the different molecular structures of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295945/ https://www.ncbi.nlm.nih.gov/pubmed/37367003 http://dx.doi.org/10.3390/bios13060638 |
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author | Zhang, Zixin Guo, Hongchen Hirai, Yuugo Takeda, Katsunori Asai, Chiho Takamura, Naohiro Niwa, Osamu |
author_facet | Zhang, Zixin Guo, Hongchen Hirai, Yuugo Takeda, Katsunori Asai, Chiho Takamura, Naohiro Niwa, Osamu |
author_sort | Zhang, Zixin |
collection | PubMed |
description | Polyion complex (PIC) materials have been widely used in biosensors due to their molecular selectivity. However, achieving both widely controllable molecular selectivity and long-term solution stability with traditional PIC materials has been challenging due to the different molecular structures of polycations (poly-C) and polyanions (poly-A). To address this issue, we propose a novel polyurethane (PU)-based PIC material in which the main chains of both poly-A and poly-C are composed of PU structures. In this study, we electrochemically detect dopamine (DA) as the analyte and L-ascorbic acid (AA) and uric acid (UA) as the interferents to evaluate the selective property of our material. The results show that AA and UA are significantly eliminated, while DA can be detected with a high sensitivity and selectivity. Moreover, we successfully tune the sensitivity and selectivity by changing the poly-A and poly-C ratios and adding nonionic polyurethane. These excellent results were employed in the development of a highly selective DA biosensor with a detection range from 500 nM to 100 μM and a 3.4 μM detection limit. Overall, our novel PIC-modified electrode has the potential to advance biosensing technologies for molecular detection. |
format | Online Article Text |
id | pubmed-10295945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102959452023-06-28 A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination Zhang, Zixin Guo, Hongchen Hirai, Yuugo Takeda, Katsunori Asai, Chiho Takamura, Naohiro Niwa, Osamu Biosensors (Basel) Article Polyion complex (PIC) materials have been widely used in biosensors due to their molecular selectivity. However, achieving both widely controllable molecular selectivity and long-term solution stability with traditional PIC materials has been challenging due to the different molecular structures of polycations (poly-C) and polyanions (poly-A). To address this issue, we propose a novel polyurethane (PU)-based PIC material in which the main chains of both poly-A and poly-C are composed of PU structures. In this study, we electrochemically detect dopamine (DA) as the analyte and L-ascorbic acid (AA) and uric acid (UA) as the interferents to evaluate the selective property of our material. The results show that AA and UA are significantly eliminated, while DA can be detected with a high sensitivity and selectivity. Moreover, we successfully tune the sensitivity and selectivity by changing the poly-A and poly-C ratios and adding nonionic polyurethane. These excellent results were employed in the development of a highly selective DA biosensor with a detection range from 500 nM to 100 μM and a 3.4 μM detection limit. Overall, our novel PIC-modified electrode has the potential to advance biosensing technologies for molecular detection. MDPI 2023-06-09 /pmc/articles/PMC10295945/ /pubmed/37367003 http://dx.doi.org/10.3390/bios13060638 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Zixin Guo, Hongchen Hirai, Yuugo Takeda, Katsunori Asai, Chiho Takamura, Naohiro Niwa, Osamu A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination |
title | A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination |
title_full | A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination |
title_fullStr | A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination |
title_full_unstemmed | A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination |
title_short | A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination |
title_sort | novel polyurethane-based polyion complex material with tunable selectivity against interferents for selective dopamine determination |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295945/ https://www.ncbi.nlm.nih.gov/pubmed/37367003 http://dx.doi.org/10.3390/bios13060638 |
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