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A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination

Polyion complex (PIC) materials have been widely used in biosensors due to their molecular selectivity. However, achieving both widely controllable molecular selectivity and long-term solution stability with traditional PIC materials has been challenging due to the different molecular structures of...

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Autores principales: Zhang, Zixin, Guo, Hongchen, Hirai, Yuugo, Takeda, Katsunori, Asai, Chiho, Takamura, Naohiro, Niwa, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295945/
https://www.ncbi.nlm.nih.gov/pubmed/37367003
http://dx.doi.org/10.3390/bios13060638
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author Zhang, Zixin
Guo, Hongchen
Hirai, Yuugo
Takeda, Katsunori
Asai, Chiho
Takamura, Naohiro
Niwa, Osamu
author_facet Zhang, Zixin
Guo, Hongchen
Hirai, Yuugo
Takeda, Katsunori
Asai, Chiho
Takamura, Naohiro
Niwa, Osamu
author_sort Zhang, Zixin
collection PubMed
description Polyion complex (PIC) materials have been widely used in biosensors due to their molecular selectivity. However, achieving both widely controllable molecular selectivity and long-term solution stability with traditional PIC materials has been challenging due to the different molecular structures of polycations (poly-C) and polyanions (poly-A). To address this issue, we propose a novel polyurethane (PU)-based PIC material in which the main chains of both poly-A and poly-C are composed of PU structures. In this study, we electrochemically detect dopamine (DA) as the analyte and L-ascorbic acid (AA) and uric acid (UA) as the interferents to evaluate the selective property of our material. The results show that AA and UA are significantly eliminated, while DA can be detected with a high sensitivity and selectivity. Moreover, we successfully tune the sensitivity and selectivity by changing the poly-A and poly-C ratios and adding nonionic polyurethane. These excellent results were employed in the development of a highly selective DA biosensor with a detection range from 500 nM to 100 μM and a 3.4 μM detection limit. Overall, our novel PIC-modified electrode has the potential to advance biosensing technologies for molecular detection.
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spelling pubmed-102959452023-06-28 A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination Zhang, Zixin Guo, Hongchen Hirai, Yuugo Takeda, Katsunori Asai, Chiho Takamura, Naohiro Niwa, Osamu Biosensors (Basel) Article Polyion complex (PIC) materials have been widely used in biosensors due to their molecular selectivity. However, achieving both widely controllable molecular selectivity and long-term solution stability with traditional PIC materials has been challenging due to the different molecular structures of polycations (poly-C) and polyanions (poly-A). To address this issue, we propose a novel polyurethane (PU)-based PIC material in which the main chains of both poly-A and poly-C are composed of PU structures. In this study, we electrochemically detect dopamine (DA) as the analyte and L-ascorbic acid (AA) and uric acid (UA) as the interferents to evaluate the selective property of our material. The results show that AA and UA are significantly eliminated, while DA can be detected with a high sensitivity and selectivity. Moreover, we successfully tune the sensitivity and selectivity by changing the poly-A and poly-C ratios and adding nonionic polyurethane. These excellent results were employed in the development of a highly selective DA biosensor with a detection range from 500 nM to 100 μM and a 3.4 μM detection limit. Overall, our novel PIC-modified electrode has the potential to advance biosensing technologies for molecular detection. MDPI 2023-06-09 /pmc/articles/PMC10295945/ /pubmed/37367003 http://dx.doi.org/10.3390/bios13060638 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Zixin
Guo, Hongchen
Hirai, Yuugo
Takeda, Katsunori
Asai, Chiho
Takamura, Naohiro
Niwa, Osamu
A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination
title A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination
title_full A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination
title_fullStr A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination
title_full_unstemmed A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination
title_short A Novel Polyurethane-Based Polyion Complex Material with Tunable Selectivity against Interferents for Selective Dopamine Determination
title_sort novel polyurethane-based polyion complex material with tunable selectivity against interferents for selective dopamine determination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295945/
https://www.ncbi.nlm.nih.gov/pubmed/37367003
http://dx.doi.org/10.3390/bios13060638
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