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Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine

Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using (35)S-GTPγS binding assays. While all of the agonists act...

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Detalles Bibliográficos
Autores principales:	Acevedo-Canabal, Agnes, Grim, Travis W., Schmid, Cullen L., McFague, Nina, Stahl, Edward L., Kennedy, Nicole M., Bannister, Thomas D., Bohn, Laura M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295947/ https://www.ncbi.nlm.nih.gov/pubmed/37371516 http://dx.doi.org/10.3390/biom13060935

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