Effects of the Combination of the C1473G Mutation in the Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior, Brain 5-HT and Melanocortin Systems in Mice

Tryptophan hydroxylase 2 (TPH2) is the key and rate-limited enzyme of serotonin (5-HT) synthesis in the brain. The C1473G mutation in the Tph2 gene results in a two-fold decrease in enzyme activity in the mouse brain. The lethal yellow (A(Y)) mutation in the Raly-Agouti locus results in the overexpr...

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Detalles Bibliográficos
Autores principales: Komleva, Polyna D., Alhalabi, Ghofran, Izyurov, Arseniy E., Khotskin, Nikita V., Kulikov, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295981/
https://www.ncbi.nlm.nih.gov/pubmed/37371543
http://dx.doi.org/10.3390/biom13060963

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