Medical Prospect of Melatonin in the Intervertebral Disc Degeneration through Inhibiting M1-Type Macrophage Polarization via SIRT1/Notch Signaling Pathway

The study aims to explore the medical prospect of melatonin (MLT) and the underlying therapeutic mechanism of MLT-mediated macrophage (Mφ) polarization on the function of nucleus pulposus (NP) in intervertebral disc degeneration (IDD). RAW 264.7 Mφs were induced by lipopolysaccharide (LPS) to simula...

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Detalles Bibliográficos
Autores principales: Dou, Xinyu, Luo, Qipeng, Xie, Linzhen, Zhou, Xuchang, Song, Chunyu, Liu, Meijuan, Liu, Xiao, Ma, Yunlong, Liu, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296002/
https://www.ncbi.nlm.nih.gov/pubmed/37371708
http://dx.doi.org/10.3390/biomedicines11061615

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