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Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network
BACKGROUND: The Global Influenza Hospital Surveillance Network (GIHSN) was established in 2012 to conduct coordinated worldwide influenza surveillance. In this study, we describe underlying comorbidities, symptoms, and outcomes in patients hospitalized with influenza. METHODS: Between November 2018...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296081/ https://www.ncbi.nlm.nih.gov/pubmed/37383245 http://dx.doi.org/10.1093/ofid/ofad244 |
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author | Andrew, Melissa K Pott, Henrique Staadegaard, Lisa Paget, John Chaves, Sandra S Ortiz, Justin R McCauley, John Bresee, Joseph Nunes, Marta C Baumeister, Elsa Raboni, Sonia Mara Giamberardino, Heloisa I G McNeil, Shelly A Gomez, Doris Zhang, Tao Vanhems, Philippe Koul, Parvaiz A Coulibaly, Daouda Otieno, Nancy A Dbaibo, Ghassan Almeida, Maria Lourdes Guerrero Laguna-Torres, Victor Alberto Drăgănescu, Anca Cristina Burtseva, Elena Sominina, Anna Danilenko, Daria Medić, Snežana Diez-Domingo, Javier Lina, Bruno |
author_facet | Andrew, Melissa K Pott, Henrique Staadegaard, Lisa Paget, John Chaves, Sandra S Ortiz, Justin R McCauley, John Bresee, Joseph Nunes, Marta C Baumeister, Elsa Raboni, Sonia Mara Giamberardino, Heloisa I G McNeil, Shelly A Gomez, Doris Zhang, Tao Vanhems, Philippe Koul, Parvaiz A Coulibaly, Daouda Otieno, Nancy A Dbaibo, Ghassan Almeida, Maria Lourdes Guerrero Laguna-Torres, Victor Alberto Drăgănescu, Anca Cristina Burtseva, Elena Sominina, Anna Danilenko, Daria Medić, Snežana Diez-Domingo, Javier Lina, Bruno |
author_sort | Andrew, Melissa K |
collection | PubMed |
description | BACKGROUND: The Global Influenza Hospital Surveillance Network (GIHSN) was established in 2012 to conduct coordinated worldwide influenza surveillance. In this study, we describe underlying comorbidities, symptoms, and outcomes in patients hospitalized with influenza. METHODS: Between November 2018 and October 2019, GIHSN included 19 sites in 18 countries using a standardized surveillance protocol. Influenza infection was laboratory-confirmed with reverse-transcription polymerase chain reaction. A multivariate logistic regression model was utilized to analyze the extent to which various risk factors predict severe outcomes. RESULTS: Of 16 022 enrolled patients, 21.9% had laboratory-confirmed influenza; 49.2% of influenza cases were A/H1N1pdm09. Fever and cough were the most common symptoms, although they decreased with age (P < .001). Shortness of breath was uncommon among those <50 years but increased with age (P < .001). Middle and older age and history of underlying diabetes or chronic obstructive pulmonary disease were associated with increased odds of death and intensive care unit (ICU) admission, and male sex and influenza vaccination were associated with lower odds. The ICU admissions and mortality occurred across the age spectrum. CONCLUSIONS: Both virus and host factors contributed to influenza burden. We identified age differences in comorbidities, presenting symptoms, and adverse clinical outcomes among those hospitalized with influenza and benefit from influenza vaccination in protecting against adverse clinical outcomes. The GIHSN provides an ongoing platform for global understanding of hospitalized influenza illness. |
format | Online Article Text |
id | pubmed-10296081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-102960812023-06-28 Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network Andrew, Melissa K Pott, Henrique Staadegaard, Lisa Paget, John Chaves, Sandra S Ortiz, Justin R McCauley, John Bresee, Joseph Nunes, Marta C Baumeister, Elsa Raboni, Sonia Mara Giamberardino, Heloisa I G McNeil, Shelly A Gomez, Doris Zhang, Tao Vanhems, Philippe Koul, Parvaiz A Coulibaly, Daouda Otieno, Nancy A Dbaibo, Ghassan Almeida, Maria Lourdes Guerrero Laguna-Torres, Victor Alberto Drăgănescu, Anca Cristina Burtseva, Elena Sominina, Anna Danilenko, Daria Medić, Snežana Diez-Domingo, Javier Lina, Bruno Open Forum Infect Dis Major Article BACKGROUND: The Global Influenza Hospital Surveillance Network (GIHSN) was established in 2012 to conduct coordinated worldwide influenza surveillance. In this study, we describe underlying comorbidities, symptoms, and outcomes in patients hospitalized with influenza. METHODS: Between November 2018 and October 2019, GIHSN included 19 sites in 18 countries using a standardized surveillance protocol. Influenza infection was laboratory-confirmed with reverse-transcription polymerase chain reaction. A multivariate logistic regression model was utilized to analyze the extent to which various risk factors predict severe outcomes. RESULTS: Of 16 022 enrolled patients, 21.9% had laboratory-confirmed influenza; 49.2% of influenza cases were A/H1N1pdm09. Fever and cough were the most common symptoms, although they decreased with age (P < .001). Shortness of breath was uncommon among those <50 years but increased with age (P < .001). Middle and older age and history of underlying diabetes or chronic obstructive pulmonary disease were associated with increased odds of death and intensive care unit (ICU) admission, and male sex and influenza vaccination were associated with lower odds. The ICU admissions and mortality occurred across the age spectrum. CONCLUSIONS: Both virus and host factors contributed to influenza burden. We identified age differences in comorbidities, presenting symptoms, and adverse clinical outcomes among those hospitalized with influenza and benefit from influenza vaccination in protecting against adverse clinical outcomes. The GIHSN provides an ongoing platform for global understanding of hospitalized influenza illness. Oxford University Press 2023-05-07 /pmc/articles/PMC10296081/ /pubmed/37383245 http://dx.doi.org/10.1093/ofid/ofad244 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Major Article Andrew, Melissa K Pott, Henrique Staadegaard, Lisa Paget, John Chaves, Sandra S Ortiz, Justin R McCauley, John Bresee, Joseph Nunes, Marta C Baumeister, Elsa Raboni, Sonia Mara Giamberardino, Heloisa I G McNeil, Shelly A Gomez, Doris Zhang, Tao Vanhems, Philippe Koul, Parvaiz A Coulibaly, Daouda Otieno, Nancy A Dbaibo, Ghassan Almeida, Maria Lourdes Guerrero Laguna-Torres, Victor Alberto Drăgănescu, Anca Cristina Burtseva, Elena Sominina, Anna Danilenko, Daria Medić, Snežana Diez-Domingo, Javier Lina, Bruno Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network |
title | Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network |
title_full | Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network |
title_fullStr | Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network |
title_full_unstemmed | Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network |
title_short | Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network |
title_sort | age differences in comorbidities, presenting symptoms, and outcomes of influenza illness requiring hospitalization: a worldwide perspective from the global influenza hospital surveillance network |
topic | Major Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296081/ https://www.ncbi.nlm.nih.gov/pubmed/37383245 http://dx.doi.org/10.1093/ofid/ofad244 |
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