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Neuropsychological Evaluation and Quantitative EEG in Patients with Frontotemporal Dementia, Alzheimer’s Disease, and Mild Cognitive Impairment
This study analyzed the efficacy of EEG resting state and neuropsychological performances in discriminating patients with different forms of dementia, or mild cognitive impairment (MCI), compared with control subjects. Forty-four patients with dementia (nineteen patients with AD, and seven with FTD)...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296106/ https://www.ncbi.nlm.nih.gov/pubmed/37371408 http://dx.doi.org/10.3390/brainsci13060930 |
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author | Tomasello, Letteria Carlucci, Leonardo Laganà, Angelina Galletta, Santi Marinelli, Chiara Valeria Raffaele, Massimo Zoccolotti, Pierluigi |
author_facet | Tomasello, Letteria Carlucci, Leonardo Laganà, Angelina Galletta, Santi Marinelli, Chiara Valeria Raffaele, Massimo Zoccolotti, Pierluigi |
author_sort | Tomasello, Letteria |
collection | PubMed |
description | This study analyzed the efficacy of EEG resting state and neuropsychological performances in discriminating patients with different forms of dementia, or mild cognitive impairment (MCI), compared with control subjects. Forty-four patients with dementia (nineteen patients with AD, and seven with FTD), eighteen with MCI, and nineteen healthy subjects, matched for age and gender, underwent an extensive neuropsychological test battery and an EEG resting state recording. Results showed greater theta activation in posterior areas in the Alzheimer’s disease (AD) and Fronto-Temporal Dementia (FTD) groups compared with the MCI and control groups. AD patients also showed more delta band activity in the temporal-occipital areas than controls and MCI patients. By contrast, the alpha and beta bands did not discriminate among groups. A hierarchical clustering analysis based on neuropsychological and EEG data yielded a three-factor solution. The clusters differed for several neuropsychological measures, as well as for beta and theta bands. Neuropsychological tests were most sensitive in capturing an initial cognitive decline, while increased theta activity was uniquely associated with a substantial worsening of the clinical picture, representing a negative prognostic factor. In line with the Research Domains Framework (RDoC) perspective, the joint use of cognitive and neurophysiological data may provide converging evidence to document the evolution of cognitive skills in at-risk individuals. |
format | Online Article Text |
id | pubmed-10296106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102961062023-06-28 Neuropsychological Evaluation and Quantitative EEG in Patients with Frontotemporal Dementia, Alzheimer’s Disease, and Mild Cognitive Impairment Tomasello, Letteria Carlucci, Leonardo Laganà, Angelina Galletta, Santi Marinelli, Chiara Valeria Raffaele, Massimo Zoccolotti, Pierluigi Brain Sci Article This study analyzed the efficacy of EEG resting state and neuropsychological performances in discriminating patients with different forms of dementia, or mild cognitive impairment (MCI), compared with control subjects. Forty-four patients with dementia (nineteen patients with AD, and seven with FTD), eighteen with MCI, and nineteen healthy subjects, matched for age and gender, underwent an extensive neuropsychological test battery and an EEG resting state recording. Results showed greater theta activation in posterior areas in the Alzheimer’s disease (AD) and Fronto-Temporal Dementia (FTD) groups compared with the MCI and control groups. AD patients also showed more delta band activity in the temporal-occipital areas than controls and MCI patients. By contrast, the alpha and beta bands did not discriminate among groups. A hierarchical clustering analysis based on neuropsychological and EEG data yielded a three-factor solution. The clusters differed for several neuropsychological measures, as well as for beta and theta bands. Neuropsychological tests were most sensitive in capturing an initial cognitive decline, while increased theta activity was uniquely associated with a substantial worsening of the clinical picture, representing a negative prognostic factor. In line with the Research Domains Framework (RDoC) perspective, the joint use of cognitive and neurophysiological data may provide converging evidence to document the evolution of cognitive skills in at-risk individuals. MDPI 2023-06-08 /pmc/articles/PMC10296106/ /pubmed/37371408 http://dx.doi.org/10.3390/brainsci13060930 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tomasello, Letteria Carlucci, Leonardo Laganà, Angelina Galletta, Santi Marinelli, Chiara Valeria Raffaele, Massimo Zoccolotti, Pierluigi Neuropsychological Evaluation and Quantitative EEG in Patients with Frontotemporal Dementia, Alzheimer’s Disease, and Mild Cognitive Impairment |
title | Neuropsychological Evaluation and Quantitative EEG in Patients with Frontotemporal Dementia, Alzheimer’s Disease, and Mild Cognitive Impairment |
title_full | Neuropsychological Evaluation and Quantitative EEG in Patients with Frontotemporal Dementia, Alzheimer’s Disease, and Mild Cognitive Impairment |
title_fullStr | Neuropsychological Evaluation and Quantitative EEG in Patients with Frontotemporal Dementia, Alzheimer’s Disease, and Mild Cognitive Impairment |
title_full_unstemmed | Neuropsychological Evaluation and Quantitative EEG in Patients with Frontotemporal Dementia, Alzheimer’s Disease, and Mild Cognitive Impairment |
title_short | Neuropsychological Evaluation and Quantitative EEG in Patients with Frontotemporal Dementia, Alzheimer’s Disease, and Mild Cognitive Impairment |
title_sort | neuropsychological evaluation and quantitative eeg in patients with frontotemporal dementia, alzheimer’s disease, and mild cognitive impairment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296106/ https://www.ncbi.nlm.nih.gov/pubmed/37371408 http://dx.doi.org/10.3390/brainsci13060930 |
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