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Recent Aptamer-Based Biosensors for Cd(2+) Detection

Cd(2+), a major environmental pollutant, is heavily toxic to human health. Many traditional techniques are high-cost and complicated; thus, developing a simple, sensitive, convenient, and cheap monitoring approach is necessary. The aptamer can be obtained from a novel method called SELEX, which is w...

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Detalles Bibliográficos
Autores principales: Gao, Zihan, Wang, Yin, Wang, Haijian, Li, Xiangxiang, Xu, Youyang, Qiu, Jieqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296115/
https://www.ncbi.nlm.nih.gov/pubmed/37366977
http://dx.doi.org/10.3390/bios13060612
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author Gao, Zihan
Wang, Yin
Wang, Haijian
Li, Xiangxiang
Xu, Youyang
Qiu, Jieqiong
author_facet Gao, Zihan
Wang, Yin
Wang, Haijian
Li, Xiangxiang
Xu, Youyang
Qiu, Jieqiong
author_sort Gao, Zihan
collection PubMed
description Cd(2+), a major environmental pollutant, is heavily toxic to human health. Many traditional techniques are high-cost and complicated; thus, developing a simple, sensitive, convenient, and cheap monitoring approach is necessary. The aptamer can be obtained from a novel method called SELEX, which is widely used as a DNA biosensor for its easy acquisition and high affinity of the target, especially for heavy metal ions detection, such as Cd(2+). In recent years, highly stable Cd(2+) aptamer oligonucleotides (CAOs) were observed, and electrochemical, fluorescent, and colorimetric biosensors based on aptamers have been designed to monitor Cd(2+). In addition, the monitoring sensitivity of aptamer-based biosensors is improved with signal amplification mechanisms such as hybridization chain reactions and enzyme-free methods. This paper reviews approaches to building biosensors for inspecting Cd(2+) by electrochemical, fluorescent, and colorimetric methods. Finally, many practical applications of sensors and their implications for humans and the environment are discussed.
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spelling pubmed-102961152023-06-28 Recent Aptamer-Based Biosensors for Cd(2+) Detection Gao, Zihan Wang, Yin Wang, Haijian Li, Xiangxiang Xu, Youyang Qiu, Jieqiong Biosensors (Basel) Review Cd(2+), a major environmental pollutant, is heavily toxic to human health. Many traditional techniques are high-cost and complicated; thus, developing a simple, sensitive, convenient, and cheap monitoring approach is necessary. The aptamer can be obtained from a novel method called SELEX, which is widely used as a DNA biosensor for its easy acquisition and high affinity of the target, especially for heavy metal ions detection, such as Cd(2+). In recent years, highly stable Cd(2+) aptamer oligonucleotides (CAOs) were observed, and electrochemical, fluorescent, and colorimetric biosensors based on aptamers have been designed to monitor Cd(2+). In addition, the monitoring sensitivity of aptamer-based biosensors is improved with signal amplification mechanisms such as hybridization chain reactions and enzyme-free methods. This paper reviews approaches to building biosensors for inspecting Cd(2+) by electrochemical, fluorescent, and colorimetric methods. Finally, many practical applications of sensors and their implications for humans and the environment are discussed. MDPI 2023-06-02 /pmc/articles/PMC10296115/ /pubmed/37366977 http://dx.doi.org/10.3390/bios13060612 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gao, Zihan
Wang, Yin
Wang, Haijian
Li, Xiangxiang
Xu, Youyang
Qiu, Jieqiong
Recent Aptamer-Based Biosensors for Cd(2+) Detection
title Recent Aptamer-Based Biosensors for Cd(2+) Detection
title_full Recent Aptamer-Based Biosensors for Cd(2+) Detection
title_fullStr Recent Aptamer-Based Biosensors for Cd(2+) Detection
title_full_unstemmed Recent Aptamer-Based Biosensors for Cd(2+) Detection
title_short Recent Aptamer-Based Biosensors for Cd(2+) Detection
title_sort recent aptamer-based biosensors for cd(2+) detection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296115/
https://www.ncbi.nlm.nih.gov/pubmed/37366977
http://dx.doi.org/10.3390/bios13060612
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