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The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings

The objective of the present study was to review recent epidemiological and clinical data on the association between selected minerals and trace elements and osteoporosis, as well as to discuss the molecular mechanisms underlying these associations. We have performed a search in the PubMed-Medline a...

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Autores principales: Skalny, Anatoly V., Aschner, Michael, Silina, Ekaterina V., Stupin, Victor A., Zaitsev, Oleg N., Sotnikova, Tatiana I., Tazina, Serafima Ia., Zhang, Feng, Guo, Xiong, Tinkov, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296274/
https://www.ncbi.nlm.nih.gov/pubmed/37371586
http://dx.doi.org/10.3390/biom13061006
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author Skalny, Anatoly V.
Aschner, Michael
Silina, Ekaterina V.
Stupin, Victor A.
Zaitsev, Oleg N.
Sotnikova, Tatiana I.
Tazina, Serafima Ia.
Zhang, Feng
Guo, Xiong
Tinkov, Alexey A.
author_facet Skalny, Anatoly V.
Aschner, Michael
Silina, Ekaterina V.
Stupin, Victor A.
Zaitsev, Oleg N.
Sotnikova, Tatiana I.
Tazina, Serafima Ia.
Zhang, Feng
Guo, Xiong
Tinkov, Alexey A.
author_sort Skalny, Anatoly V.
collection PubMed
description The objective of the present study was to review recent epidemiological and clinical data on the association between selected minerals and trace elements and osteoporosis, as well as to discuss the molecular mechanisms underlying these associations. We have performed a search in the PubMed-Medline and Google Scholar databases using the MeSH terms “osteoporosis”, “osteogenesis”, “osteoblast”, “osteoclast”, and “osteocyte” in association with the names of particular trace elements and minerals through 21 March 2023. The data demonstrate that physiological and nutritional levels of trace elements and minerals promote osteogenic differentiation through the up-regulation of BMP-2 and Wnt/β-catenin signaling, as well as other pathways. miRNA and epigenetic effects were also involved in the regulation of the osteogenic effects of trace minerals. The antiresorptive effect of trace elements and minerals was associated with the inhibition of osteoclastogenesis. At the same time, the effect of trace elements and minerals on bone health appeared to be dose-dependent with low doses promoting an osteogenic effect, whereas high doses exerted opposite effects which promoted bone resorption and impaired bone formation. Concomitant with the results of the laboratory studies, several clinical trials and epidemiological studies demonstrated that supplementation with Zn, Mg, F, and Sr may improve bone quality, thus inducing antiosteoporotic effects.
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spelling pubmed-102962742023-06-28 The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings Skalny, Anatoly V. Aschner, Michael Silina, Ekaterina V. Stupin, Victor A. Zaitsev, Oleg N. Sotnikova, Tatiana I. Tazina, Serafima Ia. Zhang, Feng Guo, Xiong Tinkov, Alexey A. Biomolecules Review The objective of the present study was to review recent epidemiological and clinical data on the association between selected minerals and trace elements and osteoporosis, as well as to discuss the molecular mechanisms underlying these associations. We have performed a search in the PubMed-Medline and Google Scholar databases using the MeSH terms “osteoporosis”, “osteogenesis”, “osteoblast”, “osteoclast”, and “osteocyte” in association with the names of particular trace elements and minerals through 21 March 2023. The data demonstrate that physiological and nutritional levels of trace elements and minerals promote osteogenic differentiation through the up-regulation of BMP-2 and Wnt/β-catenin signaling, as well as other pathways. miRNA and epigenetic effects were also involved in the regulation of the osteogenic effects of trace minerals. The antiresorptive effect of trace elements and minerals was associated with the inhibition of osteoclastogenesis. At the same time, the effect of trace elements and minerals on bone health appeared to be dose-dependent with low doses promoting an osteogenic effect, whereas high doses exerted opposite effects which promoted bone resorption and impaired bone formation. Concomitant with the results of the laboratory studies, several clinical trials and epidemiological studies demonstrated that supplementation with Zn, Mg, F, and Sr may improve bone quality, thus inducing antiosteoporotic effects. MDPI 2023-06-17 /pmc/articles/PMC10296274/ /pubmed/37371586 http://dx.doi.org/10.3390/biom13061006 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Skalny, Anatoly V.
Aschner, Michael
Silina, Ekaterina V.
Stupin, Victor A.
Zaitsev, Oleg N.
Sotnikova, Tatiana I.
Tazina, Serafima Ia.
Zhang, Feng
Guo, Xiong
Tinkov, Alexey A.
The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings
title The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings
title_full The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings
title_fullStr The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings
title_full_unstemmed The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings
title_short The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings
title_sort role of trace elements and minerals in osteoporosis: a review of epidemiological and laboratory findings
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296274/
https://www.ncbi.nlm.nih.gov/pubmed/37371586
http://dx.doi.org/10.3390/biom13061006
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