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Abnormal Resting-State Network Presence in Females with Overactive Bladder

Overactive bladder (OAB) is a global problem reducing the quality of life of patients and increasing the costs of any healthcare system. The etiology of OAB is understudied but likely involves supraspinal network alterations. Here, we characterized supraspinal resting-state functional connectivity i...

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Autores principales: Mehnert, Ulrich, Walter, Matthias, Leitner, Lorenz, Kessler, Thomas M., Freund, Patrick, Liechti, Martina D., Michels, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296293/
https://www.ncbi.nlm.nih.gov/pubmed/37371735
http://dx.doi.org/10.3390/biomedicines11061640
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author Mehnert, Ulrich
Walter, Matthias
Leitner, Lorenz
Kessler, Thomas M.
Freund, Patrick
Liechti, Martina D.
Michels, Lars
author_facet Mehnert, Ulrich
Walter, Matthias
Leitner, Lorenz
Kessler, Thomas M.
Freund, Patrick
Liechti, Martina D.
Michels, Lars
author_sort Mehnert, Ulrich
collection PubMed
description Overactive bladder (OAB) is a global problem reducing the quality of life of patients and increasing the costs of any healthcare system. The etiology of OAB is understudied but likely involves supraspinal network alterations. Here, we characterized supraspinal resting-state functional connectivity in 12 OAB patients and 12 healthy controls (HC) who were younger than 60 years. Independent component analysis showed that OAB patients had a weaker presence of the salience (Cohen’s d = 0.9) and default mode network (Cohen’s d = 1.1) and weaker directed connectivity between the fronto-parietal network and salience network with a longer lag time compared to HC. A region of interest analysis demonstrated weaker connectivity in OAB compared to HC (Cohen’s d > 1.6 or < −1.6), particularly within the frontal and prefrontal cortices. In addition, weaker seed (insula, ventrolateral prefrontal cortex) to voxel (anterior cingulate cortex, frontal gyrus, superior parietal lobe, cerebellum) connectivity was found in OAB compared to HC (Cohen’s d > 1.9). The degree of deviation in supraspinal connectivity in OAB patients (relative to HC) appears to be an indicator of the severity of the lower urinary tract symptoms and an indication that such symptoms are directly related to functional supraspinal alterations. Thus, future OAB therapy options should also consider supraspinal targets, while neuroimaging techniques should be given more consideration in the quest for better phenotyping of OAB.
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spelling pubmed-102962932023-06-28 Abnormal Resting-State Network Presence in Females with Overactive Bladder Mehnert, Ulrich Walter, Matthias Leitner, Lorenz Kessler, Thomas M. Freund, Patrick Liechti, Martina D. Michels, Lars Biomedicines Article Overactive bladder (OAB) is a global problem reducing the quality of life of patients and increasing the costs of any healthcare system. The etiology of OAB is understudied but likely involves supraspinal network alterations. Here, we characterized supraspinal resting-state functional connectivity in 12 OAB patients and 12 healthy controls (HC) who were younger than 60 years. Independent component analysis showed that OAB patients had a weaker presence of the salience (Cohen’s d = 0.9) and default mode network (Cohen’s d = 1.1) and weaker directed connectivity between the fronto-parietal network and salience network with a longer lag time compared to HC. A region of interest analysis demonstrated weaker connectivity in OAB compared to HC (Cohen’s d > 1.6 or < −1.6), particularly within the frontal and prefrontal cortices. In addition, weaker seed (insula, ventrolateral prefrontal cortex) to voxel (anterior cingulate cortex, frontal gyrus, superior parietal lobe, cerebellum) connectivity was found in OAB compared to HC (Cohen’s d > 1.9). The degree of deviation in supraspinal connectivity in OAB patients (relative to HC) appears to be an indicator of the severity of the lower urinary tract symptoms and an indication that such symptoms are directly related to functional supraspinal alterations. Thus, future OAB therapy options should also consider supraspinal targets, while neuroimaging techniques should be given more consideration in the quest for better phenotyping of OAB. MDPI 2023-06-05 /pmc/articles/PMC10296293/ /pubmed/37371735 http://dx.doi.org/10.3390/biomedicines11061640 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mehnert, Ulrich
Walter, Matthias
Leitner, Lorenz
Kessler, Thomas M.
Freund, Patrick
Liechti, Martina D.
Michels, Lars
Abnormal Resting-State Network Presence in Females with Overactive Bladder
title Abnormal Resting-State Network Presence in Females with Overactive Bladder
title_full Abnormal Resting-State Network Presence in Females with Overactive Bladder
title_fullStr Abnormal Resting-State Network Presence in Females with Overactive Bladder
title_full_unstemmed Abnormal Resting-State Network Presence in Females with Overactive Bladder
title_short Abnormal Resting-State Network Presence in Females with Overactive Bladder
title_sort abnormal resting-state network presence in females with overactive bladder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296293/
https://www.ncbi.nlm.nih.gov/pubmed/37371735
http://dx.doi.org/10.3390/biomedicines11061640
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