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Unlocking the Power of Nanopores: Recent Advances in Biosensing Applications and Analog Front-End
The biomedical field has always fostered innovation and the development of various new technologies. Beginning in the last century, demand for picoampere-level current detection in biomedicine has increased, leading to continuous breakthroughs in biosensor technology. Among emerging biomedical sensi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296294/ https://www.ncbi.nlm.nih.gov/pubmed/37366963 http://dx.doi.org/10.3390/bios13060598 |
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author | Liu, Miao Li, Junyang Tan, Cherie S. |
author_facet | Liu, Miao Li, Junyang Tan, Cherie S. |
author_sort | Liu, Miao |
collection | PubMed |
description | The biomedical field has always fostered innovation and the development of various new technologies. Beginning in the last century, demand for picoampere-level current detection in biomedicine has increased, leading to continuous breakthroughs in biosensor technology. Among emerging biomedical sensing technologies, nanopore sensing has shown great potential. This paper reviews nanopore sensing applications, such as chiral molecules, DNA sequencing, and protein sequencing. However, the ionic current for different molecules differs significantly, and the detection bandwidths vary as well. Therefore, this article focuses on current sensing circuits, and introduces the latest design schemes and circuit structures of different feedback components of transimpedance amplifiers mainly used in nanopore DNA sequencing. |
format | Online Article Text |
id | pubmed-10296294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102962942023-06-28 Unlocking the Power of Nanopores: Recent Advances in Biosensing Applications and Analog Front-End Liu, Miao Li, Junyang Tan, Cherie S. Biosensors (Basel) Review The biomedical field has always fostered innovation and the development of various new technologies. Beginning in the last century, demand for picoampere-level current detection in biomedicine has increased, leading to continuous breakthroughs in biosensor technology. Among emerging biomedical sensing technologies, nanopore sensing has shown great potential. This paper reviews nanopore sensing applications, such as chiral molecules, DNA sequencing, and protein sequencing. However, the ionic current for different molecules differs significantly, and the detection bandwidths vary as well. Therefore, this article focuses on current sensing circuits, and introduces the latest design schemes and circuit structures of different feedback components of transimpedance amplifiers mainly used in nanopore DNA sequencing. MDPI 2023-05-31 /pmc/articles/PMC10296294/ /pubmed/37366963 http://dx.doi.org/10.3390/bios13060598 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Miao Li, Junyang Tan, Cherie S. Unlocking the Power of Nanopores: Recent Advances in Biosensing Applications and Analog Front-End |
title | Unlocking the Power of Nanopores: Recent Advances in Biosensing Applications and Analog Front-End |
title_full | Unlocking the Power of Nanopores: Recent Advances in Biosensing Applications and Analog Front-End |
title_fullStr | Unlocking the Power of Nanopores: Recent Advances in Biosensing Applications and Analog Front-End |
title_full_unstemmed | Unlocking the Power of Nanopores: Recent Advances in Biosensing Applications and Analog Front-End |
title_short | Unlocking the Power of Nanopores: Recent Advances in Biosensing Applications and Analog Front-End |
title_sort | unlocking the power of nanopores: recent advances in biosensing applications and analog front-end |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296294/ https://www.ncbi.nlm.nih.gov/pubmed/37366963 http://dx.doi.org/10.3390/bios13060598 |
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