KRAS and NRAS Translation Is Increased upon MEK Inhibitors-Induced Processing Bodies Dissolution

SIMPLE SUMMARY: Cancer therapies directly targeting the mitogen-activated protein kinase (MAPK) pathway lead to cancer drug resistance. Resistance has been linked to compensatory RAS overexpression, but the mechanisms underlying this overexpression remain unclear. Here, we find that MEK inhibitors (...

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Detalles Bibliográficos
Autores principales: Vidal-Cruchez, Olivia, Nicolini, Victoria J., Rete, Tifenn, Jacquet, Karine, Rezzonico, Roger, Lacoux, Caroline, Domdom, Marie-Angela, Roméo, Barnabé, Roux, Jérémie, Hubstenberger, Arnaud, Mari, Bernard, Mograbi, Baharia, Hofman, Paul, Brest, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296394/
https://www.ncbi.nlm.nih.gov/pubmed/37370689
http://dx.doi.org/10.3390/cancers15123078

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