Cargando…

Role of Intracellular Drug Disposition in the Response of Acute Myeloid Leukemia to Cytarabine and Idarubicin Induction Chemotherapy

SIMPLE SUMMARY: The impact of genes involved in drug transport and metabolism in regard to the lack of response of acute myeloid leukemia (AML) cells to induction chemotherapy using cytarabine and idarubicin has been investigated in blast cells collected at diagnosis. The aim of this study was to ev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodríguez-Macías, Gabriela, Briz, Oscar, Cives-Losada, Candela, Chillón, María C., Martínez-Laperche, Carolina, Martínez-Arranz, Ibon, Buño, Ismael, González-Díaz, Marcos, Díez-Martín, José L., Marin, Jose J. G., Macias, Rocio I. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296567/ https://www.ncbi.nlm.nih.gov/pubmed/37370755 http://dx.doi.org/10.3390/cancers15123145

Ejemplares similares

Mechanisms of Anticancer Drug Resistance in Hepatoblastoma
por: Marin, Jose J. G., et al.
Publicado: (2019)

Genetic Heterogeneity of SLC22 Family of Transporters in Drug Disposition
por: Lozano, Elisa, et al.
Publicado: (2018)

Idarubicin Plus Behenoyl Cytarabine and 6-thioguanine Compares Favorably with Idarubicin Plus Cytarabine-based Regimen for Children with Previously Untreated Acute Myeloid Leukemia: 10-Year Retrospective, Multicenter Study in Korea
por: Lee, Dae Hyoung, et al.
Publicado: (2010)

Efficacy and toxicity of midostaurin with idarubicin and cytarabine induction in FLT3-mutated acute myeloid leukemia
por: Lee, Julia S., et al.
Publicado: (2023)

Plasma Membrane Transporters as Biomarkers and Molecular Targets in Cholangiocarcinoma
por: Marin, Jose J.G., et al.
Publicado: (2020)

Meta-Analysis of Randomised Clinical Trials Comparing Idarubicin + Cytarabine with Daunorubicin + Cytarabine as the Induction Chemotherapy in Patients with Newly Diagnosed Acute Myeloid Leukaemia
por: Wang, Jing, et al.
Publicado: (2013)

Initial Report of a Phase I Study of LY2510924, Idarubicin, and Cytarabine in Relapsed/Refractory Acute Myeloid Leukemia
por: Boddu, Prajwal, et al.
Publicado: (2018)

Lactation during cholestasis: Role of ABC proteins in bile acid traffic across the mammary gland
por: Blazquez, Alba M. G., et al.
Publicado: (2017)

Combined treatment of rituximab, idarubicin, dexamethasone, cytarabine, methotrexate with radiotherapy for primary central nervous system lymphoma
por: Zhao, Defeng, et al.
Publicado: (2014)

The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy
por: Marin, Jose JG, et al.
Publicado: (2014)

Novel Pharmacological Options in the Treatment of Cholangiocarcinoma: Mechanisms of Resistance
por: Marin, Jose J. G., et al.
Publicado: (2021)

Molecular Bases of Mechanisms Accounting for Drug Resistance in Gastric Adenocarcinoma
por: Marin, Jose J. G., et al.
Publicado: (2020)

Molecular Bases of Drug Resistance in Hepatocellular Carcinoma
por: Marin, Jose J.G., et al.
Publicado: (2020)

Expression of Chemoresistance-Associated ABC Proteins in Hepatobiliary, Pancreatic and Gastrointestinal Cancers
por: Marin, Jose J. G., et al.
Publicado: (2022)

Clinical utility of targeted next‐generation sequencing for the diagnosis of myeloid neoplasms with germline predisposition
por: Andrés‐Zayas, Cristina, et al.
Publicado: (2021)

The efficacy and safety of daunorubicin versus idarubicin combined with cytarabine for induction therapy in acute myeloid leukemia: A meta-analysis of randomized clinical trials
por: Wang, Hanyu, et al.
Publicado: (2020)

A phase I study of lenalidomide plus chemotherapy with idarubicin and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high‐risk myelodysplastic syndrome
por: Saygin, Caner, et al.
Publicado: (2020)

High efficacy of azacitidine combined with homoharringtonine, idarubicin, and cytarabine in newly diagnosed patients with AML: A single arm, phase 2 trial
por: Li, Jun, et al.
Publicado: (2022)

Viral Clearance with Neutrophil Recovery in a Patient with Active COVID-19 Infection and Refractory Acute Myeloid Leukemia Who Underwent Successful Reinduction with Cytarabine/Idarubicin
por: Dean, Erin A., et al.
Publicado: (2022)

Role of equilibrative nucleoside transporter 1 (ENT1) in the disposition of cytarabine in mice
por: Anderson, Jason T., et al.
Publicado: (2019)

Role of drug transporters in the sensitivity of acute myeloid leukemia to sorafenib
por: Macias, Rocio I.R., et al.
Publicado: (2018)

Next Generation Cytogenetics in Myeloid Hematological Neoplasms: Detection of CNVs and Translocations
por: Chicano, María, et al.
Publicado: (2021)

Next-Generation Sequencing Improves Diagnosis, Prognosis and Clinical Management of Myeloid Neoplasms
por: Carbonell, Diego, et al.
Publicado: (2019)

Confocal microscopy of idarubicin localisation.
por: Manfait, M., et al.
Publicado: (1997)

Fludarabine, idarubicin, and cytarabine regimen together with TKI followed by haploidentical hematopoietic stem cell transplantation, a success for relapsed Ph+ acute lymphoblastic leukemia
por: Sang, Wei, et al.
Publicado: (2016)

A comparative study of idarubicin 12 mg/m(2) and 8 mg/m(2) combined with cytarabine as the first induction regimen for adult acute myeloid leukemia patients
por: Zhou, Li, et al.
Publicado: (2016)

Exome sequencing reveals heterogeneous clonal dynamics in donor cell myeloid neoplasms after stem cell transplantation
por: Suárez-González, Julia, et al.
Publicado: (2020)

Models for Understanding Resistance to Chemotherapy in Liver Cancer
por: Marin, Jose J. G., et al.
Publicado: (2019)

Usefulness of the MRP2 promoter to overcome the chemoresistance of gastrointestinal and liver tumors by enhancing the expression of the drug transporter OATP1B1
por: Herraez, Elisa, et al.
Publicado: (2017)

Confocal microscopy of idarubicin localisation - reply
por: Duffy, P, et al.
Publicado: (1997)

Effects of intensive induction and consolidation chemotherapy with idarubicin and high dose cytarabine on minimal residual disease levels in newly diagnosed adult precursor-B acute lymphoblastic leukemia()
por: Bradstock, Kenneth F., et al.
Publicado: (2016)

FLT3-ITD Expression as a Potential Biomarker for the Assessment of Treatment Response in Patients with Acute Myeloid Leukemia
por: Carbonell, Diego, et al.
Publicado: (2022)

Treatment outcome of doxorubicin versus idarubicin in adult acute myeloid leukemia
por: Sherif, Hemat Afifi, et al.
Publicado: (2021)

Novel Candidate loci and Pathogenic Germline Variants Involved in Familial Hematological Malignancies Revealed by Whole-Exome Sequencing
por: Andrés-Zayas, Cristina, et al.
Publicado: (2023)

ST2 and REG3α as Predictive Biomarkers After Haploidentical Stem Cell Transplantation Using Post-transplantation High-Dose Cyclophosphamide
por: Solán, Laura, et al.
Publicado: (2019)

Elafin as a Predictive Biomarker of Acute Skin Graft-Versus-Host Disease After Haploidentical Stem Cell Transplantation Using Post-Transplant High-Dose Cyclophosphamide
por: Solán, Laura, et al.
Publicado: (2021)

Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
por: Chehimi, Mohamad, et al.
Publicado: (2016)

Short Tandem Repeats (STRs) as Biomarkers for the Quantitative Follow-Up of Chimerism after Stem Cell Transplantation: Methodological Considerations and Clinical Application
por: Navarro-Bailón, Almudena, et al.
Publicado: (2020)

Busulfan and Fludarabine Conditioning Regimen Given at Hematological Nadir of Cytoreduction Fludarabine, Cytarabine, and Idarubicin Chemotherapy in Patients With Refractory Acute Myeloid Leukemia Undergoing Allogeneic Stem Cell Transplantation: A Single Arm Pilot Consort Study
por: Tang, Wei, et al.
Publicado: (2015)

Intracellular disposition of chitosan nanoparticles in macrophages: intracellular uptake, exocytosis, and intercellular transport
por: Jiang, Li Qun, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fd709msrt8qm210aafrm3dov7u