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Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis

With the increasing of altitude activities from low-altitude people, the study of high altitude cerebral edema (HACE) has been revived. HACE is a severe acute mountain sickness associated with exposure to hypobaric hypoxia at high altitude, often characterized by disturbance of consciousness and ata...

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Autores principales: Li, Yubo, Li, Chengming, Luo, Tao, Yue, Tian, Xiao, Wenjing, Yang, Ling, Zhang, Zaiyuan, Han, Fei, Long, Pan, Hu, Yonghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296571/
https://www.ncbi.nlm.nih.gov/pubmed/37383357
http://dx.doi.org/10.2147/JIR.S415695
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author Li, Yubo
Li, Chengming
Luo, Tao
Yue, Tian
Xiao, Wenjing
Yang, Ling
Zhang, Zaiyuan
Han, Fei
Long, Pan
Hu, Yonghe
author_facet Li, Yubo
Li, Chengming
Luo, Tao
Yue, Tian
Xiao, Wenjing
Yang, Ling
Zhang, Zaiyuan
Han, Fei
Long, Pan
Hu, Yonghe
author_sort Li, Yubo
collection PubMed
description With the increasing of altitude activities from low-altitude people, the study of high altitude cerebral edema (HACE) has been revived. HACE is a severe acute mountain sickness associated with exposure to hypobaric hypoxia at high altitude, often characterized by disturbance of consciousness and ataxia. As for the pathogenesis of HACE, previous studies suggested that it might be related to the disorder of cerebral blood flow, the destruction of blood-brain barrier and the injury of brain parenchyma cells caused by inflammatory factors. In recent years, studies have confirmed that the imbalance of REDOX homeostasis is also involved in the pathogenesis of HACE, which mainly leads to abnormal activation of microglia and destruction of tight junction of vascular endothelial cells through the excessive production of mitochondrial-related reactive oxygen species. Therefore, this review summarizes the role of REDOX homeostasis and the potential of the treatment of REDOX homeostasis in HACE, which is of great significance to expand the understanding of the pathogenesis of HACE. Moreover, it will also be helpful to further study the possible therapy of HACE related to the key link of REDOX homeostasis.
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spelling pubmed-102965712023-06-28 Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis Li, Yubo Li, Chengming Luo, Tao Yue, Tian Xiao, Wenjing Yang, Ling Zhang, Zaiyuan Han, Fei Long, Pan Hu, Yonghe J Inflamm Res Review With the increasing of altitude activities from low-altitude people, the study of high altitude cerebral edema (HACE) has been revived. HACE is a severe acute mountain sickness associated with exposure to hypobaric hypoxia at high altitude, often characterized by disturbance of consciousness and ataxia. As for the pathogenesis of HACE, previous studies suggested that it might be related to the disorder of cerebral blood flow, the destruction of blood-brain barrier and the injury of brain parenchyma cells caused by inflammatory factors. In recent years, studies have confirmed that the imbalance of REDOX homeostasis is also involved in the pathogenesis of HACE, which mainly leads to abnormal activation of microglia and destruction of tight junction of vascular endothelial cells through the excessive production of mitochondrial-related reactive oxygen species. Therefore, this review summarizes the role of REDOX homeostasis and the potential of the treatment of REDOX homeostasis in HACE, which is of great significance to expand the understanding of the pathogenesis of HACE. Moreover, it will also be helpful to further study the possible therapy of HACE related to the key link of REDOX homeostasis. Dove 2023-06-23 /pmc/articles/PMC10296571/ /pubmed/37383357 http://dx.doi.org/10.2147/JIR.S415695 Text en © 2023 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Li, Yubo
Li, Chengming
Luo, Tao
Yue, Tian
Xiao, Wenjing
Yang, Ling
Zhang, Zaiyuan
Han, Fei
Long, Pan
Hu, Yonghe
Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis
title Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis
title_full Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis
title_fullStr Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis
title_full_unstemmed Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis
title_short Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis
title_sort progress in the treatment of high altitude cerebral edema: targeting redox homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296571/
https://www.ncbi.nlm.nih.gov/pubmed/37383357
http://dx.doi.org/10.2147/JIR.S415695
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