Alternative mRNA Splicing Controls the Functions of the Histone H3K27 Demethylase UTX/KDM6A

SIMPLE SUMMARY: UTX/KDM6A is a histone H3K27 demethylase and plays an important role in mammalian development and human diseases such as urothelial cancer. We identified a region encompassing exons 12–17 of UTX that undergoes extensive splicing events. As a result, a nuclear localization sequence lo...

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Autores principales: Fotouhi, Omid, Nizamuddin, Sheikh, Falk, Stephanie, Schilling, Oliver, Knüchel-Clarke, Ruth, Biniossek, Martin L., Timmers, H. T. Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296593/
https://www.ncbi.nlm.nih.gov/pubmed/37370727
http://dx.doi.org/10.3390/cancers15123117

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