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The Role of the Microbiome in First Episode of Psychosis

The relationship between the gut-brain-microbiome axis has gained great importance in the study of psychiatric disorders, as it may represent a new target for their treatment. To date, the available literature suggests that the microbiota may influence the pathophysiology of several diseases, includ...

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Autores principales: Nuncio-Mora, Lucero, Lanzagorta, Nuria, Nicolini, Humberto, Sarmiento, Emmanuel, Ortiz, Galo, Sosa, Fernanda, Genis-Mendoza, Alma Delia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296647/
https://www.ncbi.nlm.nih.gov/pubmed/37371865
http://dx.doi.org/10.3390/biomedicines11061770
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author Nuncio-Mora, Lucero
Lanzagorta, Nuria
Nicolini, Humberto
Sarmiento, Emmanuel
Ortiz, Galo
Sosa, Fernanda
Genis-Mendoza, Alma Delia
author_facet Nuncio-Mora, Lucero
Lanzagorta, Nuria
Nicolini, Humberto
Sarmiento, Emmanuel
Ortiz, Galo
Sosa, Fernanda
Genis-Mendoza, Alma Delia
author_sort Nuncio-Mora, Lucero
collection PubMed
description The relationship between the gut-brain-microbiome axis has gained great importance in the study of psychiatric disorders, as it may represent a new target for their treatment. To date, the available literature suggests that the microbiota may influence the pathophysiology of several diseases, including psychosis. The aim of this review is to summarize the clinical and preclinical studies that have evaluated the differences in microbiota as well as the metabolic consequences related to psychosis. Current data suggest that the genera Lactobacillus and Megasphaera are increased in schizophrenia (SZ), as well as alterations in the glutamate-glutamine-GABA cycle, serum levels of tryptophan, kynurenic acid (KYNA), and short-chain fatty acids (SCFAs). There are still very few studies on early-onset psychosis, thus more studies are needed to be able to propose targeted therapies for a point when the disease has just started or has not yet progressed.
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spelling pubmed-102966472023-06-28 The Role of the Microbiome in First Episode of Psychosis Nuncio-Mora, Lucero Lanzagorta, Nuria Nicolini, Humberto Sarmiento, Emmanuel Ortiz, Galo Sosa, Fernanda Genis-Mendoza, Alma Delia Biomedicines Review The relationship between the gut-brain-microbiome axis has gained great importance in the study of psychiatric disorders, as it may represent a new target for their treatment. To date, the available literature suggests that the microbiota may influence the pathophysiology of several diseases, including psychosis. The aim of this review is to summarize the clinical and preclinical studies that have evaluated the differences in microbiota as well as the metabolic consequences related to psychosis. Current data suggest that the genera Lactobacillus and Megasphaera are increased in schizophrenia (SZ), as well as alterations in the glutamate-glutamine-GABA cycle, serum levels of tryptophan, kynurenic acid (KYNA), and short-chain fatty acids (SCFAs). There are still very few studies on early-onset psychosis, thus more studies are needed to be able to propose targeted therapies for a point when the disease has just started or has not yet progressed. MDPI 2023-06-20 /pmc/articles/PMC10296647/ /pubmed/37371865 http://dx.doi.org/10.3390/biomedicines11061770 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nuncio-Mora, Lucero
Lanzagorta, Nuria
Nicolini, Humberto
Sarmiento, Emmanuel
Ortiz, Galo
Sosa, Fernanda
Genis-Mendoza, Alma Delia
The Role of the Microbiome in First Episode of Psychosis
title The Role of the Microbiome in First Episode of Psychosis
title_full The Role of the Microbiome in First Episode of Psychosis
title_fullStr The Role of the Microbiome in First Episode of Psychosis
title_full_unstemmed The Role of the Microbiome in First Episode of Psychosis
title_short The Role of the Microbiome in First Episode of Psychosis
title_sort role of the microbiome in first episode of psychosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296647/
https://www.ncbi.nlm.nih.gov/pubmed/37371865
http://dx.doi.org/10.3390/biomedicines11061770
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