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Efficacy of Early Optimization of Infliximab Guided by Therapeutic Drug Monitoring during Induction—A Prospective Trial

Therapeutic drug monitoring (TDM) during induction therapy with anti-tumor necrosis factor drugs has emerged as a strategy to optimize response to these biologics and avoid undesired outcomes related to inadequate drug exposure. This study aimed to describe clinical, biological, and endoscopic remis...

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Detalles Bibliográficos
Autores principales: Garcia, Karoline Soares, de Azevedo, Matheus Freitas Cardoso, Carlos, Alexandre de Sousa, Barros, Luísa Leite, Oba, Jane, Sobrado Junior, Carlos Walter, Sipahi, Aytan Miranda, Alves, Olívia Duarte de Castro, Navarro-Rodriguez, Tomás, Parra, Rogério Serafim, Chebli, Júlio Maria Fonseca, Chebli, Liliana Andrade, Flores, Cristina, Vieira, Andrea, do Ceará, Christianne Damasceno Arcelino, Queiroz, Natália Sousa Freitas, Damião, Aderson Omar Mourão Cintra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296671/
https://www.ncbi.nlm.nih.gov/pubmed/37371853
http://dx.doi.org/10.3390/biomedicines11061757
Descripción
Sumario:Therapeutic drug monitoring (TDM) during induction therapy with anti-tumor necrosis factor drugs has emerged as a strategy to optimize response to these biologics and avoid undesired outcomes related to inadequate drug exposure. This study aimed to describe clinical, biological, and endoscopic remission rates at six months in Brazilian inflammatory bowel disease (IBD) patients following a proactive TDM algorithm guided by IFX trough levels (ITL) and antibodies to IFX (ATI) levels during induction, at week six. A total of 111 IBD patients were prospectively enrolled, excluding those previously exposed to the drug. ITL ≥ 10 μg/mL was considered optimal. Patients with suboptimal ITL (<10 µg/mL) were guided according to ATI levels. Those who presented ATI ≤ 200 ng/mL underwent dose intensification in the maintenance phase, and patients with ATI > 200 ng/mL discontinued IFX. In our study, proactive TDM was associated with persistence in the IFX rate at six months of 82.9%. At that time, rates of clinical, biological, and endoscopic remission in patients under IFX treatment were 80.2%, 73.9%, and 48.1%, respectively. Applying a simplified TDM-guided algorithm during induction seems feasible and can help improve patients’ outcomes in clinical practice.