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The Functional Role of Group 2 Innate Lymphoid Cells in Asthma

Asthma is a heterogeneous disease characterized by chronic airway inflammation. Group 2 innate lymphoid cells (ILC2) play an important role in the pathogenesis of asthma. ILC2s lack antigen-specific receptors and respond to epithelial-derived cytokines, leading to the induction of airway eosinophili...

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Autores principales: Matsuyama, Takahiro, Machida, Kentaro, Mizuno, Keiko, Matsuyama, Hiromi, Dotake, Yoichi, Shinmura, Masahiro, Takagi, Koichi, Inoue, Hiromasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296683/
https://www.ncbi.nlm.nih.gov/pubmed/37371472
http://dx.doi.org/10.3390/biom13060893
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author Matsuyama, Takahiro
Machida, Kentaro
Mizuno, Keiko
Matsuyama, Hiromi
Dotake, Yoichi
Shinmura, Masahiro
Takagi, Koichi
Inoue, Hiromasa
author_facet Matsuyama, Takahiro
Machida, Kentaro
Mizuno, Keiko
Matsuyama, Hiromi
Dotake, Yoichi
Shinmura, Masahiro
Takagi, Koichi
Inoue, Hiromasa
author_sort Matsuyama, Takahiro
collection PubMed
description Asthma is a heterogeneous disease characterized by chronic airway inflammation. Group 2 innate lymphoid cells (ILC2) play an important role in the pathogenesis of asthma. ILC2s lack antigen-specific receptors and respond to epithelial-derived cytokines, leading to the induction of airway eosinophilic inflammation in an antigen-independent manner. Additionally, ILC2s might be involved in the mechanism of steroid resistance. Numerous studies in both mice and humans have shown that ILC2s induce airway inflammation through inflammatory signals, including cytokines and other mediators derived from immune or non-immune cells. ILC2s and T helper type 2 (Th2) cells collaborate through direct and indirect interactions to organize type 2 immune responses. Interestingly, the frequencies or numbers of ILC2 are increased in the blood and bronchoalveolar lavage fluid of asthma patients, and the numbers of ILC2s in the blood and sputum of severe asthmatics are significantly larger than those of mild asthmatics. These findings may contribute to the regulation of the immune response in asthma. This review article highlights our current understanding of the functional role of ILC2s in asthma.
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spelling pubmed-102966832023-06-28 The Functional Role of Group 2 Innate Lymphoid Cells in Asthma Matsuyama, Takahiro Machida, Kentaro Mizuno, Keiko Matsuyama, Hiromi Dotake, Yoichi Shinmura, Masahiro Takagi, Koichi Inoue, Hiromasa Biomolecules Review Asthma is a heterogeneous disease characterized by chronic airway inflammation. Group 2 innate lymphoid cells (ILC2) play an important role in the pathogenesis of asthma. ILC2s lack antigen-specific receptors and respond to epithelial-derived cytokines, leading to the induction of airway eosinophilic inflammation in an antigen-independent manner. Additionally, ILC2s might be involved in the mechanism of steroid resistance. Numerous studies in both mice and humans have shown that ILC2s induce airway inflammation through inflammatory signals, including cytokines and other mediators derived from immune or non-immune cells. ILC2s and T helper type 2 (Th2) cells collaborate through direct and indirect interactions to organize type 2 immune responses. Interestingly, the frequencies or numbers of ILC2 are increased in the blood and bronchoalveolar lavage fluid of asthma patients, and the numbers of ILC2s in the blood and sputum of severe asthmatics are significantly larger than those of mild asthmatics. These findings may contribute to the regulation of the immune response in asthma. This review article highlights our current understanding of the functional role of ILC2s in asthma. MDPI 2023-05-26 /pmc/articles/PMC10296683/ /pubmed/37371472 http://dx.doi.org/10.3390/biom13060893 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matsuyama, Takahiro
Machida, Kentaro
Mizuno, Keiko
Matsuyama, Hiromi
Dotake, Yoichi
Shinmura, Masahiro
Takagi, Koichi
Inoue, Hiromasa
The Functional Role of Group 2 Innate Lymphoid Cells in Asthma
title The Functional Role of Group 2 Innate Lymphoid Cells in Asthma
title_full The Functional Role of Group 2 Innate Lymphoid Cells in Asthma
title_fullStr The Functional Role of Group 2 Innate Lymphoid Cells in Asthma
title_full_unstemmed The Functional Role of Group 2 Innate Lymphoid Cells in Asthma
title_short The Functional Role of Group 2 Innate Lymphoid Cells in Asthma
title_sort functional role of group 2 innate lymphoid cells in asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296683/
https://www.ncbi.nlm.nih.gov/pubmed/37371472
http://dx.doi.org/10.3390/biom13060893
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